Publications by authors named "Xu-He Zhao"
Pyridostigmine attenuates hypertension by inhibiting activation of the renin-angiotensin system in the hypothalamic paraventricular nucleus.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Article Synopsis
- - Activation of the renin-angiotensin system (RAS) leads to oxidative stress and inflammation in the hypothalamic paraventricular nucleus (PVN), causing sympathetic hyperactivity and contributing to hypertension.
- - A study on 2-kidney one-clip (2K1C) rats found that pyridostigmine improved cardiovascular function and lowered blood pressure by restoring autonomic balance and reducing levels of inflammatory cytokines and oxidative stress markers in the PVN.
- - Pyridostigmine also inhibited the RAS in the PVN by decreasing levels of angiotensin-converting enzyme (ACE) and angiotensin II, while increasing expression of the angiotensin II type 2 receptor