Publications by Xu-Hao Gong

Publications by authors named "Xu-Hao Gong"

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Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway.

Yuan-Yuan Wei Hui-Ru Wang Yi-Meng Fan Jin-Hua Gu Xiu-Ying Zhang Xu-Hao Gong

Ecotoxicol Environ Saf

February 2023

Article Synopsis

This study investigated how Gandankang (GDK) aqueous extract helps reduce acute liver injury caused by carbon tetrachloride (CCl) in both mice and liver cells (HepG2).
The results indicate that GDK not only prevents liver damage but also improves liver function by blocking inflammatory and oxidative stress pathways.
GDK appears to work by inhibiting liver fibrosis, regulating proteins related to oxidative stress, and reducing lipid peroxide generation, thereby protecting liver cells from damage.

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Mori fructus aqueous extracts attenuate carbon tetrachloride-induced renal injury via the Nrf2 pathway and intestinal flora.

Yuan-Yuan Wei Yan-Nan Zhang Huiru Wang Yu Ga Yimeng Fan Xu-Hao Gong

Ecotoxicol Environ Saf

October 2022

Mori fructus aqueous extracts (MFAEs) have been used as a traditional Chinese medicine for thousands of years with the function of strengthening the liver and tonifying the kidney. However, its inner mechanism to alleviative renal injury is unclear. To investigate the attenuation of MFAEs on nephrotoxicity and uncover its potential molecular mechanism, we established a nephrotoxicity model induced by carbon tetrachloride (CCl).

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