Publications by authors named "Xu-Feng Pan"
Article Synopsis
- The study examines the impact of donor-derived infection (DDI) from multidrug-resistant organisms, focusing on the use of a novel Xpert Carba-R assay to quickly detect carbapenem-resistant organisms (CRO) in donor lungs before transplantation.
- By screening 35 potential donors, the study found that 25.71% had positive results, leading to their lungs being declined for transplantation, while 74.29% of recipients received CRO-negative donor lungs.
- Results show that the Xpert Carba-R screening group had significantly lower CRO-related mortality within 60 days post-transplantation compared to the control group, indicating the effectiveness of real-time screening in improving patient outcomes.
Background: The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which needs to be explored further.
View Article and Find Full Text PDFBackground: Lymphoepithelioma-like carcinoma (LELC) is a rare form of non-small cell lung carcinoma. The current study focused on its clinicopathological features and potential factors influencing the prognosis.
Methods: The statistical analysis was based on the clinicopathological records and the prognosis of 43 LELC patients, analyzed by Kaplan-Meier method, Log-rank test, and COX regression analysis.
[Correlation analysis between imaging features and lymph node metastasis in T1a lung adenocarcinoma].
Zhonghua Wai Ke Za Zhi
October 2013
Objective: To analyze the data of patients with clinical stage T1a lung adenocarcinoma and find the predictive factors associated with lymph node metastasis.
Methods: From January to June 2012, 271 patients with small nodules of peripheral lung adenocarcinoma were enrolled in the retrospective review. There were 105 male and 112 female patients, with an average age of (61 ± 11)years (range 32-85 years).
Identification of candidate genes for lung cancer somatic mutation test kits.
Genet Mol Biol
September 2013
Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer. The ability to identify the actual sequence of gene mutations may help doctors determine which mutations lead to precancerous lesions and which produce invasive carcinomas, especially using next-generation sequencing (NGS) technology. In this study, we analyzed the latest lung cancer data in the COSMIC database, in order to find genomic "hotspots" that are frequently mutated in human lung cancer genomes.
View Article and Find Full Text PDFPurpose: Lung cancer is the leading cause of cancer death worldwide, but techniques for effective early diagnosis are still lacking. Proteomics technology has been applied extensively to the study of the proteins involved in carcinogenesis. In this paper, a classification method was developed based on principal components of surface-enhanced laser desorption/ionization (SELDI) spectral data.
View Article and Find Full Text PDFObjectives: Neoadjuvant therapy for the treatment of oesophageal cancer was introduced in an effort to improve prognosis. Response assessment is crucial for the treatment of patients with oesophageal cancer. Currently, ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) seems to be the best available tool to assess neoadjuvant therapy response in patients with oesophageal cancer.
View Article and Find Full Text PDFThe purpose of this study was to investigate GPC3 gene expression in lung squamous cell carcinoma tissue and its correlation with clinical and tumor characteristics. Using RT-PCR, the presence of GPC3 gene expression was detected in cancer tissue and adjacent normal tissue in 66 cases of lung squamous cell carcinoma and positive rates were calculated. Using Western blot, changes in GPC3 protein expression were detected in lung squamous cell carcinoma and adjacent normal tissues.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how vascular endothelial growth factor-A and E-cadherin, among other factors, can predict outcomes in patients after surgery for stage I non-small cell lung cancer.
- A total of 185 patients were analyzed, revealing that nearly half expressed high levels of vascular endothelial growth factor-A and over half were E-cadherin-negative, with both markers showing significant correlations with different clinical features.
- Multivariate analysis found that gender and the expression levels of vascular endothelial growth factor-A and E-cadherin were independent prognostic indicators for overall survival post-surgery.
Objective: To detect the expression of VEGF-C mRNA and to investigate its relationship with clinicopathological parameters in esophageal squamous cell carcinoma (ESCC).
Methods: Real-time quantitative reverse transcriptase-PCR was used to measure the level of VEGF-C mRNA in the tumor tissue and corresponding normal mucosa in ESCC patients.
Results: The VEGF-C mRNA expression in tumor tissue was significantly higher than that in the corresponding normal mucosa (6.