Publications by authors named "Xu-Fang Fan"
Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.
Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).
Article Synopsis
- This study examined the use and effects of inhaled nitric oxide (iNO) in preterm infants under 34 weeks gestational age across eight hospitals in China over a span of ten years.
- A total of 434 infants were analyzed, categorized into three gestational age groups: extremely preterm (24-27 weeks), very preterm (28-31 weeks), and moderate preterm (32-33 weeks), focusing on treatment outcomes and complications.
- Findings indicated that extremely preterm infants had the highest rates of iNO treatment and associated complications, with mortality rates inversely related to gestational age and birth weight, underscoring the importance of iNO in managing severe respiratory issues in this population.