Sensitive fluorescence turn-on sensing of hydroxyl radical and glucose based on the oxidative degradation of reductive organic cage.

The accurate and sensitive quantification of hydroxyl radical (·OH) and glucose is necessary for disease diagnosis and health guidance, but still challenging owing to the low concentration of ·OH and poor water solubility of fluorescent probes. In addition, fluorescent probes may cause secondary pollution to the environment. Here an organic cage was reported as a sensitive fluorescent probe for ·OH and glucose in aqueous solution without serious secondary pollution.

Enantioselective Assessment of Etoxazole Enantiomers in Earthworms (): Bioaccumulation, Degradation, Transcriptome, and Oxidative Stress.

This study systemically investigated the enantioselective bioaccumulation and degradation of etoxazole (ETZ) in earthworms along with the transcriptome and oxidative stress responses to ETZ enantiomer exposure. Based on the M-shaped bioaccumulation trends for ETZ enantiomers, -ETZ was found to be preferentially bioaccumulated in earthworms. Sublethal toxicity analysis showed that -ETZ induced greater changes in protein content, malondialdehyde content, detoxifying metabolic enzyme activity, and oxidative stress in earthworms, compared to those induced by -ETZ.

Enantioselectivity Mechanism of Etoxazole Enantiomers in : Acaricidal Activity, Metabolic Difference, and Target Binding.

Etoxazole, a widely used mite growth inhibitor, contains a chiral center in its chemical structure, resulting in two mirror-image enantiomers. These enantiomers of etoxazole display significant differences in biological activity and environmental behavior. In bioassays conducted against , it was observed that S-etoxazole demonstrated approximately 279.

Utilizing combined quantitative multiparametric MRI as potential biomarkers for improved early-stage parkinson's disease diagnosis.

Background: Identifying Parkinson's disease (PD) during its initial phases presents considerable hurdles for clinicians.

Purpose: To examine the feasibility and efficacy of a machine learning model based on quantitative multiparametric magnetic resonance imaging (MRI) features in identifying early-stage PD.

Methods: We recruited 33 participants, including 19 with early-stage PD, 14 with advanced-stage PD and 20 healthy control subjects.

Enhanced mite control and agricultural safety with etoxazole-loaded chitin nanocrystals: Synthesis, characterization, and ecological impacts.

Chitin nanocrystals (ChNCs), known for their high aspect ratio, surface charge, and mobility, are promising bio-based nanomaterials for drug delivery. However, their potential as pesticide carriers in agriculture remains underexplored. Etoxazole, a diphenyl oxalate acaricide, effectively inhibits egg hatching and the normal molting process in mites but suffers from rapid degradation and short persistence in field applications.

Development and Validation of Multiparametric MRI-based Interpretable Deep Learning Radiomics Fusion Model for Predicting Lymph Node Metastasis and Prognosis in Rectal Cancer: A Two-center Study.

Rationale And Objectives: To develop interpretable machine learning models that utilize deep learning (DL) and radiomics based on multiparametric Magnetic resonance imaging (MRI) to predict preoperative lymph node (LN) metastasis in rectal cancer.

Materials And Methods: This retrospective study involved 286 cancer patients confirmed by histopathology from center 1 (Training set) and 66 patients from center 2 (External test set). Radiomics features were extracted from T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) sequences, whereas DL features were obtained using four models: MobileNet-V3-large, Inception-V3, ResNet50, and VGG16.

Unique S-scheme structures in electrostatic self-assembled ReS-TiO for high-efficiency perfluorooctanoic acid removal.

Perfluorinated compounds (PFCs), recognized as persistent organic pollutants, resist degradation in the environment due to the high bond energy of the C-F. Increasing carrier density via adopting electrostatic self-assembly strategy has been shown to effectively cleave C-F bonds. In this work, a unique S-scheme structure was fabricated by combining oppositely charged semiconductors, TiO and ReS, through electrostatic self-assembly.

Evaluation of radiation induced brain injury in nasopharyngeal carcinoma patients based on multi-parameter quantitative MRI: A prospective longitudinal study.

Purpose: Three dimensional pulsed continuous arterial spin labeling (3D-pCASL) and incoherent movement within voxels (IVIM) imaging was combined to assess dynamic microscopic structure changes of the hippocampus and temporal lobe white matter (TLWM) of nasopharyngeal carcinoma (NPC) patients post intensity-modulated radiation therapy (IMRT).

Methods: Forty-six patients who were first diagnosed with NPC and underwent IMRT were prospectively enrolled. 3D-CASL and IVIM were performed pre-RT, within 1 week (1 W) post-RT, 3 months (3 M) post-RT, 6 months (6 M) post-RT, and 18 months (18 M) post-RT.

Comparative study of fenpropathrin and its main metabolite in soil-earthworm microcosms: Toxicity, degradation, transcriptome, and oxidative stress.

This study comprehensively investigated the comparative acute toxicities, degradation, transcriptome, and oxidative stress induction of fenpropathrin (FEN) and its main metabolite 3-phenoxybenzoic acid (3-PBA)in soil-earthworm microcosms. FEN degradation half-life ranged from 19.09 to 28.

Promoting elemental mercury immobilization performance from smelting flue gas over a wide temperature range via cobalt-doped copper sulfide adsorbents.

Copper sulfide (CuS) sorbent exhibits great potential for gaseous elemental mercury (Hg) decontamination, but it still suffers from a narrow operating temperature. Therefore, designing advanced CuS sorbents that have a high activity level for capturing Hg and thermal stability at a high temperature range is challenging. Herein, we propose a metal doping strategy to fabricate a bimetallic sulfide adsorbent.

Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging.

In this study, nitrogen-sulfur codoped carbon quantum dots (N-S/CQDs) with various functions and properties were synthesized through a one-step method utilizing citric acid and cysteine as reaction substrates. The fluorescence of N-S/CQDs can be specifically quenched by permanganate ion (MnO ), and the quenched fluorescence can be recovered by the presence of reduced glutathione (GSH). A fluorescence sensing system based on N-S/CQDs@MnO was developed and successfully applied for the determination of GSH in pharmaceutical preparations.

Repeat administration of human umbilical cord mesenchymal stem cells improves left ventricular diastolic function in mice with heart failure with preserved ejection fraction.

Currently, no therapy is proven to effectively improve heart failure with preserved ejection fraction (HFpEF). Although stem cell therapy has demonstrated promising results in treating ischemic heart disease, the effectiveness of treating HFpEF with human umbilical cord mesenchymal stem cells (hucMSCs) remains unclear. To answer this question, we administered hucMSCs intravenously (i.

CT-based radiomics combined with clinical features for invasiveness prediction and pathological subtypes classification of subsolid pulmonary nodules.

Purpose: To construct optimal models for predicting the invasiveness and pathological subtypes of subsolid nodules (SSNs) based on CT radiomics and clinical features.

Materials And Methods: This study was a retrospective study involving two centers. A total of 316 patients with 353 SSNs confirmed as atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) were included from January 2019 to February 2023.

ICAM-1 may promote the loss of dopaminergic neurons by regulating inflammation in MPTP-induced Parkinson's disease mouse models.

Parkinson's disease (PD) is a chronic neurodegenerative disease with unclear pathogenesis that involves neuroinflammation and intestinal microbial dysbiosis. Intercellular adhesion molecule-1 (ICAM-1), an inflammatory marker, participates in neuroinflammation during dopaminergic neuronal damage. However, the explicit mechanisms of action of ICAM-1 in PD have not been elucidated.

Effectiveness and Safety of Radiofrequency Ablation versus Liver Resection in the Treatment of Early-stage Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Objective: To systematically evaluate the efficacy and safety of radiofrequency ablation and liver resection in the therapeutic management of early-stage hepatocellular carcinoma.

Method: We conducted a comprehensive search of domestic and foreign databases including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang to retrieve literature on radiofrequency ablation and liver resection for the treatment of early hepatocellular carcinoma. The retrieved literature underwent thorough screening, and relevant data were extracted.

Construction of A Smart Hospital Innovation Platform Using the Internet + Technology.

Objective: This study aims to investigate the practical application of "Internet + technology" leveraging medical big data to enhance the development of a smart hospital platform. Specifically, the focus is on optimizing patient care processes, refining medical data management systems, and enhancing operational efficiency within the hospital setting.

Methods: With the help of traditional Internet and mobile Internet technology, we analyzed the patient behavior big data accumulated in our hospital for many years, simplified the diagnosis and treatment links, refined the service connotation, and improved patient satisfaction before, during and after diagnosis; With the help of barcode, RFID and 5G networks, the links that are easy to produce medical security incidents can be monitored to improve medical quality, such as digital operating room system, establishment of multidisciplinary consultation center (MDT), electronic medical record system based on digital signature, etc.

Systemic evaluation of novel acaricide hexythiazox for bioactivity improvement and risk reduction at the enantiomer level.

Traditional risk assessments of chiral pesticides mainly depend on racemic form, which is often incomprehensive. This study conducted systemic investigations on the bioactivity, toxicity, and ecotoxicological effects of hexythiazox (HTZ) at the enantiomer level. The elution order and absolute configuration of HTZ enantiomers were determined.

Multi‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy.

The present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All patients underwent conventional magnetic resonance imaging, plus IVIM and ASL imaging of the bilateral parotid glands within 2 weeks prior to RT, and 1 week (1W) and 3 months (3M) following RT.

Radiological characteristics predicting early poor drug response in patients with hemifacial spasm.

Objectives: Patients with hemifacial spasm (HFS) often resort to botulinum toxin injections or microvascular decompression surgery when medication exhibits limited effectiveness. This study aimed to identify MRI and demographic factors associated with poor drug response at an early stage in patients with HFS.

Methods: We retrospectively included patients with HFS who underwent pre-therapeutic MRI examination.

Development and validation of a nomogram based on CT texture analysis for discriminating minimally invasive adenocarcinoma from glandular precursor lesions in sub‑centimeter pulmonary ground glass nodules.

In a recent reclassification, adenocarcinoma has been redefined as a glandular precursor lesion (GPL), alongside adenomatous hyperplasia. This updated classification necessitates corresponding adaptations in clinical diagnostic and therapeutic protocols. Consequently, the present study aimed to construct and validate a nomogram utilizing computed tomography (CT) texture features to effectively discriminate between minimally invasive adenocarcinoma (MIA) and GPL within sub-centimeter pulmonary ground glass nodules (GGNs).

rapid synthesis of ionic liquid/ionic covalent organic framework composites for CO fixation.

IL/ICOF composites were synthesized a one-pot route in half an hour under ambient conditions for catalytic cycloaddition of CO with epoxides into cyclic carbonates. The prepared composites feature a decent CO adsorption capacity of 1.63 mmol g at 273 K and 1 bar and exhibit excellent catalytic performance in terms of yield and durability.

Enantioselective metabolism of fenpropathrin enantiomers by carboxyl/choline esterase 6 in Tetranychus cinnabarinus.

Background: Tetranychus cinnabarinus is a polyphagous pest mite commonly found in agriculture. As an excellent acaricide, fenpropathrin (FEN) is frequently used to control T. cinnabarinus in agriculture.