Two new cytochalasins from the endophytic fungus sp. GDGJ-77B.

Two new open-chain cytochalasins, xylarchalasins A and B ( and ), together with six known analogues (-), were isolated from the endophytic fungus sp. GDGJ-77B from the Chinese medicinal plant . Their structures were elucidated on the basis of comprehensive spectroscopic analysis.

MCU proteins dominate in vivo mitochondrial Ca2+ uptake in Arabidopsis roots.

Ca2+ signaling is central to plant development and acclimation. While Ca2+-responsive proteins have been investigated intensely in plants, only a few Ca2+-permeable channels have been identified, and our understanding of how intracellular Ca2+ fluxes is facilitated remains limited. Arabidopsis thaliana homologs of the mammalian channel-forming mitochondrial calcium uniporter (MCU) protein showed Ca2+ transport activity in vitro.

Efficacy of angiotensin receptor neprilysin inhibitor in Asian patients with refractory hypertension.

Sacubitril/valsartan, simultaneously inhibits neprilysin and angiotensin II receptor, showed an effect in reducing blood pressure (BP). The authors aimed to study whether it can be used as an antihypertensive agent in patients with refractory hypertension who have already been treated. A total of 66 Chinese patients with refractory hypertension were enrolled.

Three new andrastin derivatives from the endophytic fungus .

Three new andrastin derivatives, 10-formyl andrastone A (), 10-demethylated andrastone A () and andrastin G (), together with four known andrastin analogues (-) were isolated from an endophytic fungus . Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound exhibited significant antibacterial activity against B with an MIC value of 6.

LncRNA HCG11/miR-26b-5p/QKI5 feedback loop reversed high glucose-induced proliferation and angiogenesis inhibition of HUVECs.

Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one of the primary causes of cerebrovascular and cardiovascular events. Neovascularization within the plaque is closely associated with its stability. Long non-coding RNA (lncRNA) serves a crucial role in regulating vascular endothelial cells (VECs) proliferation and angiogenesis.

Author Correction: Genome-wide identification of Major Intrinsic Proteins in Glycine soja and characterization of GmTIP2;1 function under salt and water stress.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cytochalasins from endophytic sp. GDG-118.

The plant , possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus sp. GDG-118 was fermented and extracted with methanol.

Two new phthalide derivatives from the endophytic fungus isolated from .

Two new phthalide derivatives, (-)-3-carboxypropyl-7-hydroxyphthalide () and (-)-3-carboxypropyl-7-hydroxyphthalide methyl ester (), were isolated from the endophytic fungus isolated from the Chinese medicinal plant . Their structures were elucidated using spectroscopic methods, mainly on 1D and 2D NMR. Compound exhibited medium antibacterial activities against and with MIC values of 12.

Cellular Ca Signals Generate Defined pH Signatures in Plants.

Ca play a key role in cell signaling across organisms. The question of how a simple ion can mediate specific outcomes has spurred research into the role of Ca signatures and their encoding and decoding machinery. Such studies have frequently focused on Ca alone and our understanding of how Ca signaling is integrated with other responses is poor.

GmWRKY49, a Salt-Responsive Nuclear Protein, Improved Root Length and Governed Better Salinity Tolerance in Transgenic .

Plant WRKY transcription factors (TFs) are active guardians against pathogens' insurgency, key components in developmental processes, contributors in signal transduction pathways, and regulators of diverse biotic and abiotic stress responses. In this research, we isolated, cloned, and functionally characterized a new WRKY TF GmWRKY49 from soybean. GmWRKY49 is a nuclear protein which contains two highly conserved WRKY domains and a CH-type zinc-finger structure.

Preexcitation syndrome: experimental study on the electrocardiogram of antegradely conducting accessory pathway.

Background: Preexcitation syndrome is characterized by a dominant delta wave on the baseline electrocardiogram (ECG), resulting from the change in QRS initial vector by the accessory pathway (AP). This study is to explore the effect of ventricular preexcitation on the QRS initial, maximal and terminal vector in an experimental rabbit with preexcitation syndrome induced by programmed electrical stimulation.

Methods: Rabbits (n = 10) were randomized for the experimental model of ventricular preexcitation.

Salinity Tolerance Mechanism of Osmotin and Osmotin-like Proteins: A Promising Candidate for Enhancing Plant Salt Tolerance.

Introduction: Salt stress is one of the most important abiotic stress factors which severely affect agricultural production. Osmotins and OLPs (osmotin like proteins) are kinds of proteins which were produced during plant adapting to the environmental stress.

Objective: These proteins were closely related to osmotic regulation and resistance stress.

Heterologous expression of GmSIP1;3 from soybean in tobacco showed and growth retardation and tolerance to hydrogen peroxide.

Aquaporins (AQPs) are transmembrane protein channels that are members of Major Intrinsic Proteins (MIP) superfamily. AQPs play important roles in plant reproduction, cell elongation, osmoregulation, influence leaf physiology and are responsive to drought and salt tolerance. Small intrinsic proteins (SIPs)belongs to one of the groups of AQPs, which are mainly localized to endoplasmic reticulum(ER).