[Influence of Tongfu Xiefei Guanchang Solution on intestinal barrier and intestinal flora of rats with acute lung injury based on p38 MAPK/MLCK signaling pathway].

The study is designed to observe the mechanism of Tongfu Xiefei Guanchang Solution(TFXF) in the treatment of acute lung injury(ALI) in rats by improving intestinal barrier and intestinal flora structure via p38 mitogen-activated protein kinase(p38 MAPK)/myosin light chain kinase(MLCK) signaling pathway. Sixty SPF-grade Wistar rats were randomly divided into the control(CON) group, lipopolysaccharide(LPS) group(7.5 mg·kg~(-1)), LPS + dexamethasone(DEX) group(3.

[Integrated evidence chain: a new strategy and methodology for effectiveness e valuation of traditional Chinese medicines].

The evaluation of the effectiveness of traditional Chinese medicine(TCM) has long been a "bottleneck" issue that restricts the healthy development and internationalization of TCM. This article systematically analyzes the differences in diagnostic and treatment principles, material composition, new drug development pathways, efficacy cognition, and evaluation methodology between Chinese and Western medicine from the underlying logic of medical perspective. On this basis, it integrates the evidence elements of clinical experience, experimental research, and clinical trials, and for the first time proposes and establishes a new strategy and methodology for the evaluation of the effectiveness of TCM: the integrated evidence chain-based effectiveness evaluation of traditional Chinese medicine(iEC-Eff), forming an integrated evaluation and confirmation model of "clinical experience-experimental research-clinical trial" for the effectiveness of TCM.

Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury.

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below the injury level or permanent loss of function in severe cases. Dynamic spatiotemporal neuroinflammation is vital to neurological recovery, which is collectively constituted by the dynamic changes in a series of inflammatory cells, including microglia, neutrophils, and astrocytes, among others. Immunomodulatory nanomaterials can readily improve the therapeutic effects and simultaneously overcome various drawbacks associated with treatment, such as the off-target side effects and loss of bioactivity of immune agents during circulation.

Metabolomics based early warning model for acute kidney injury risk in patients exposed to diquat.

Acute kidney injury (AKI) is one of the most important indications of severe clinical symptoms in patients with diquat poisoning and is closely related to poor prognosis. However, current studies have rarely focused on early warnings of diquat-related AKI, which is not conducive to the treatment of patients with early clinical diquat poisoning. In this study, untargeted plasma metabolomics was employed to reveal the differences between diquat-poisoned patients with and without AKI, as well as between patients and healthy volunteers.

Antimicrobial activity of octyl gallate nanoemulsion combined with photodynamic technology and its effect on food preservation.

Photodynamic inactivation, as a safe and effective antimicrobial technology that does not damage the organoleptic properties of the food itself, decreases the use of preservatives and is gradually gaining attention in the food industry. This study selected octyl gallate (OG) as an antimicrobial photosensitizer with eucalyptus oil as the oil phase and prepared it as an octyl gallate nanoemulsion (OG-NE) to ensure the delivery of the photosensitizer. Escherichia coli and Staphylococcus aureus inactivation with the OG-NE combined with photodynamic technology, as well as the effect on the quality of food products, was investigated.

The landscape in telomere related gene prognostic signature for survival and medication treatment effectiveness prediction in hepatocellular carcinoma.

Objective: Telomeres, made of repetitive DNA sequences and shelterin complexes, which were found at the ends of chromosomes and had been extensively studied in cancer research. However, in hepatocellular carcinoma (HCC) was still relatively scarce. In this study, we investigated the correlation between telomerase-related genes (TRGs) and the prognosis and immunotherapy of HCC patients to enhance clinical outcomes.

Triggering Oxygen Redox Cycles in Nickel Ferrite by Octahedral Geometry Engineering for Enhancing Oxygen Evolution.

Spinel-type nickel ferrite (NiFeO, x≤1) is a widely used electrocatalyst for the oxygen evolution reaction (OER). Due to the lower hybridization of metal-d and oxygen-p orbitals, the OER process on NiFeO follows the sluggish adsorbate evolution mechanism (AEM). Generally, activating the lattice oxygen to trigger the lattice-oxygen-mediated mechanism (LOM) can enhance the OER activity.

The Effect of CBM1 and Linker on the Oxidase, Peroxidase and Monooxygenase Activities of AA9 LPMOs: Insight into Their Correlation with the Nature of Reductants and Crystallinity of Celluloses.

This study explores the effect of carbohydrate-binding module 1 (CBM1) and the linker on the function of auxiliary activity 9 (AA9) lytic polysaccharide monooxygenases (LPMOs), with a particular focus on monooxygenase activity, using different crystallinity celluloses and electron donors. The tested C1/C4-oxidizing AA9 LPMOs exhibited higher oxidase and peroxidase activities compared to those of the C4-oxidizing AA9 LPMOs. While the presence of CBM1 promoted cellulose-binding affinity, it reduced the oxidase activity of modular AA9 LPMOs.

Machine learning-based prediction and model interpretability analysis for algal growth affected by microplastics.

Microplastics (MPs), the plastic debris smaller than 5 mm, are ubiquitous in waterbodies and have been shown to be toxic to aquatic organisms, especially to microalgae. The aim of this study is to use machine learning models to predict the effects of MPs on algal growth and to evaluate the relative importance of different features (MP properties, algal characteristics, and experimental conditions) through model interpretability analysis. Based on literature search, 408 samples were collected as inputs for the models.

Structure and crystallization behavior of aqueous KCl-MgCl solutions.

Potassium resources are abundant in the brine of chloride-type salt lakes. The main challenge in the efficient separation and extraction of potassium from salt lakes lies in the insufficient understanding of the structure and crystallization behavior of brine solutions and their correlation. In the present work, X-ray scattering (XRS) and computational simulation methods were used to study the microstructure of KCl and MgCl mixed solutions, including the hydration and association structures of ions in the solutions.

Epilepsy and Developmental Delay in Pediatric Patients With PTEN Variants and a Literature Review.

Background: Epilepsy is not common in pediatric patients with phosphatase and tensin homolog (PTEN) variants. The characteristics of epilepsy, reactions to antiseizure medications, and prognosis in these patients are not fully understood. The aim of this study was to elucidate the characteristics of epilepsy and developmental outcomes in pediatric patients with PTEN variants.

Dual-Indicator loaded porous polymer microneedle patches for rapid and colorimetric detection of water-injected meat.

Water-injected meat leads to microbial growth, which affects the health of consumers. A colorimetric porous polymer microneedle patch was designed and prepared using photopolymerization of an acrylate monomer with porogen to be the substrate, and cobalt (II) chloride as color change indicator and tartrazine as the reference. The color of the microneedle patch changed from green to yellow green and to yellow as the increase of moisture concentration.

Silver functionalized chitosan composite hydrogel with sustained silver release and enhanced antibacterial properties promotes healing of infected wounds.

Bacterial infections during wound healing often cause inflammation, which delays the healing process. Therefore, innovative wound dressings are urgently needed to inhibit bacterial infections and promote healing. This study proposes an Ag-functionalized chitosan hydrogel dressing, formed via a Schiff-base reaction between alkynyl Ag substituted chitosan (Ag-CS) and octafunctionalized polyhedral oligomeric silsesquioxane with benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO), to address the issue of bacterial infection in wounds.

Treatment options for unilateral vestibular schwannoma: a network meta-analysis.

This study aimed to explore the effect of observation, microsurgery, and radiotherapy for patients with vestibular schwannoma (VS). We searched PubMed, Medline, Embase, Web of Science, and Cochrane library from their establishment to July 31, 2024. 34 non-RCTs and 1 RCT that included 6 interventions were analyzed.

Unveiling the Hidden Reactivity in the -Heterocyclic Carbene-Catalyzed Aerobic Oxidation of Aldehydes: Unlocking Its Powerful Catalytic Performance.

An innovative solution that overcomes the long-standing inherently low efficiency in -heterocyclic carbene-catalyzed aerobic oxidation of aldehydes is reported. This solution included the design and synthesis of a novel polymerized catalyst and the utilization of a flow reactor. The unprecedentedly high efficiency achieved via this protocol makes it synthetically applicable.

Development and evaluation of a sulfate precipitation method for separating key flocculated-species from titanium-based flocculant.

Key flocculated-species is the pivotal factor influencing the effectiveness of flocculants, which in turn directly determines the performance of mainstream wastewater treatment processes. Recovery of titanium-coagulated sludge and high-efficiency of titanium-coagulation have made titanium-coagulants an attractive hot point. However, the separation of key titanium-based flocculated-species remains a critical bottleneck limiting the advancement of titanium-based flocculant chemistry in water treatment.

Exploring the impact of substitution and conformational variations on the copigmentation ability of monomeric flavan-3-ols in wine.

Monomeric flavan-3-ols are important copigments in red wines, due to their superior copigmentation ability and high concentration. In this work, a systematic study was conducted on the copigmentation effects of eight common monomeric flavan-3-ols with malvidin-3-O-glucoside, using experimental and theoretical methods. The results revealed that the addition of a hydroxy group to the B ring and the attachment of a galloyl group at the 3-O position of monomeric flavan-3-ols both contributed to enhance copigmentation, with the latter exerting a more pronounced effect.

Comparative effects of ciprofol and propofol on perioperative outcomes: a systematic review and meta-analysis of randomized controlled trials.

Background: The ideal anesthetic agents for sedation, considering their respiratory and cardiovascular benefits and other perioperative or postoperative outcomes, are still unclear. This systematic review and meta-analysis aimed to evaluate whether ciprofol has advantages over propofol for sedation, particularly concerning respiratory and cardiovascular outcomes and other relevant perioperative measures.

Methods: We conducted a comprehensive search of PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and two Chinese databases for randomized controlled trials comparing intravenous ciprofol and propofol for sedation.

Based on green synthesis, multisensory evaluations and molecular simulation approaches: Exploring the taste-enhancing characteristics and mechanisms of N-succinyl-L-leucine.

N-Succinyl amino acids (N-Suc-AAs) are increasingly recognized for their potential as taste-active compounds. However, research into the green synthesis, taste-enhancing properties, and mechanisms of N-succinyl-L-leucine (N-Suc-Leu) remains limited. This study employed an enzymatic synthesis method, catalyzed by protamex and pancreatin, to produce N-Suc-Leu, with its structure confirmed.

Bibliometric analysis of research hotspots and trends on the relationship between the gut microbiota and depression from 2020 to 2024.

Introduction: In recent years, an increasing body of research has illustrated a strong correlation between gut microbiota and depression. However, there has yet to be a comprehensive discussion or summary of the latest advancements and trends in this field.

Methods: We retrieved research articles focused on gut microbiota and depression through the WOS database from 2020 to 2024, using visual text analysis tools such as CiteSpace and VOSviewer.

Relationship Between Resilience, Emergency Response Capacity, and Occupational Stressors of New Nurse During the Re-outbreak of COVID-19 in China.

Objectives: The emergency response capacity of nurses is quite important during the COVID-19 epidemic. This study aimed to determine the relationship of resilience with emergency response capacity and occupational stresses during COVID-19 re-outbreak.

Methods: This is a cross-sectional study that involved 241 new nurses.

Preparation, characterisation and evaluation of kaempferol phospholipid complex and its application in preventing the deterioration of soybean oil.

This study aims to improve the solubility of kaempferol (KA) by preparing a kaempferol phospholipid complex (KA-PC), which can be applied to prevent soybean oil from spoilage. KA-PC was prepared by solvent evaporation and characterised by FTIR, DSC, and XRD. Furthermore, KA-PC was added to soybean oil and the peroxide value and acid value were determined.

Collaborative disposal of beryllium-containing wastewater with modified graphite@chitosan from waste lithium-ion batteries.

In order to recover and effectively remove beryllium from beryllium-containing wastewater and relieve the environmental pressure caused by waste batteries. In this study, the gel material was synthesized based on the modified graphite material separated from the waste battery, and the graphite-@chitosan composite gel (CWBG@CH) was designed and synthesized. Interestingly, CWBG@CH has a maximum fitted adsorption capacity (Q) of 83.