Association of breastfeeding practices during the first 12 months and subsequent infant respiratory tract infections: a prospective cohort study.

Background: Breastfeeding and human milk are the normative standards for infant feeding and nutrition.

Objectives: We aimed to examine the association of breastfeeding practices during the first year of life with subsequent infant respiratory tract infections (RTIs).

Methods: The study was a secondary analysis embedded in the Tongji Maternal and Child Health Cohort study.

Physical Vapor Deposition of High-Mobility P-Type Tellurium and Its Applications for Gate-Tunable van der Waals PN Photodiodes.

Recently, tellurium has attracted resurgent interest due to its outstanding p-type characteristics and ambient environmental stability. Here, we present a substrate engineering-based physical vapor deposition method to synthesize high-quality Te nanoflakes and achieved a field-effect hole mobility of 1450 cm/(V s), which is, to the best of our knowledge, the highest among existing synthesized two-dimensional p-type semiconductors. The high mobility of Te enables the fabrication of Te/MoS PN diodes with highly gate-tunable characteristics.

Coordination Regulation Enabling Deep Eutectic Electrolyte for Fast-Charging High-Voltage Lithium Metal Batteries.

The safety and cycle stability of lithium metal batteries (LMBs) under conditions of high cut-off voltage and fast charging put forward higher requirements for electrolytes. Here, a sulfonate-based deep eutectic electrolyte (DEE) resulting from the eutectic effect between solid sultone and lithium bis(trifluoromethanesulfonyl)imide without any other additives is reported. The intermolecular coordination effect triggers this eutectic phenomenon, as evidenced with nuclear magnetic resonance, and thus the electrochemical behavior of the DEE can be controlled by jointly regulating the coordination effects of F···H and Li···O intermolecular interactions.

Development, validation, and clinical application of LC-MS/MS method for simultaneous determination of ibrutinib, zanubrutinib, orelabrutinib, acalabrutinib, and their active metabolites in patients with B-cell lymphoma.

Bruton's tyrosine kinase inhibitors (BTKis) exhibit significant interindividual pharmacokinetics, making therapeutic drug monitoring (TDM) a promising approach for personalized therapy. However, simultaneous quantification of multiple BTKis poses technical challenges. A unified protocol for BTKis detection would be clinically desirable.

Buried hole-selective interface engineering for high-efficiency tin-lead perovskite solar cells with enhanced interfacial chemical stability.

Mixed Sn-Pb perovskites are attracting significant attention due to their narrow bandgap and consequent potential for all-perovskite tandem solar cells. However, the conventional hole transport materials can lead to band misalignment or induce degradation at the buried interface of perovskite. Here we designed a self-assembled material 4-(9H-carbozol-9-yl)phenylboronic acid (4PBA) for the surface modification of the substrate as the hole-selective contact.

Biomimetic flame retardant adhesive via combining polysiloxane, chitosan and vermiculite nanosheets inspired by nacre and arthropod cuticle.

The wood industry's dependence on traditional petrochemical adhesives, which pose environmental and health risks, has spurred research into sustainable alternatives. Sustainable bio-based polysaccharide materials show promise due to their inherent adhesive properties, despite challenges related to mechanical weaknesses and water resistance. Inspired by the hardening mechanisms of nacre and arthropod cuticles, we have developed a novel biomimetic flame-retardant HPA/OCTS/VMT NSs-NH adhesive.

Bio-inspired anti-swelling amyloid-fiber lysozyme adhesive for rapid wound closure and hemostasis.

Instant adhesion to wet biological surfaces and reduced swelling of tissue adhesives are crucial for rapid wound closure and hemostasis. However, previous strategies to reduce swelling were always accompanied by a decrease in the tissue bonding strength of the adhesive. Moreover, the irreducibility of the covalent bonds in currently reported adhesives results in the adhesives losing their tissue adhesive ability.

Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Unlabelled: Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. We hypothesize that MEVs cross host cellular barriers and deliver their cargoes of bioactive compounds to the brain.

Development and validation of intravoxel incoherent motion diffusion weighted imaging-based model for preoperative distinguishing nuclear grade and survival of clear cell renal cell carcinoma complicated with venous tumor thrombus.

Objective: To assess the utility of multiparametric MRI and clinical indicators in distinguishing nuclear grade and survival of clear cell renal cell carcinoma (ccRCC) complicated with venous tumor thrombus (VTT).

Materials And Methods: This study included 105 and 27 patients in the training and test sets, respectively. Preoperative MRI, including intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), was performed.

Realization of high-end PET devices that assist conventional PET devices in improving image quality via diffusion modeling.

Purpose: This study aimed to implement high-end positron emission tomography (PET) equipment to assist conventional PET equipment in improving image quality via a distribution learning-based diffusion model.

Methods: A diffusion model was first trained on a dataset of high-quality (HQ) images acquired by a high-end PET device (uEXPLORER scanner), and the quality of the conventional PET images was later improved on the basis of this trained model built on null-space constraints. Data from 180 patients were used in this study.

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation.

HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for the eradication of viral reservoirs. Previous reports have shown that tannic acid (TA) exerts several biological functions, including antioxidant and antitumor activities.

Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1.

PIK-75 (F7) is a potent multikinase inhibitor that targets p110α, DNA-PK, and p38γ. PIK-75 has shown potential as a therapy in preclinical cancer models, but it has not been used in the clinic, at least in part, due to limited solubility. We therefore developed a nanoparticle to encapsulate PIK-75 and enable targeted cellular delivery.

Copper-Catalyzed Enantioselective Skeletal Editing through a Formal Nitrogen Insertion into Indoles to Synthesize Atropisomeric Aminoaryl Quinoxalines.

Skeletal editing represents an attractive strategy for adding complexity to a given molecular scaffold in chemical synthesis. Isodesmic reactions provide a complementary skeletal editing approach for the redistribution of chemical bonds in chemical synthesis. However, catalytic enantioselective isodesmic reaction is extremely scarce and enantioselective isodesmic reaction to synthesize atropisomeric compounds is unknown.

Recent Advances of Small Extracellular Vesicles for the Regulation and Function of Cancer-Associated Fibroblasts.

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells to recipient cells. Previous studies have demonstrated that CAFs play important roles in tumor progression by regulating tumor cell proliferation, metastasis, therapeutic resistance, and metabolism via sEVs.

A Chemiluminescence Signal Amplification Method for MicroRNA Detection: The Combination of Molecular Aptamer Beacons with Enzyme-Free Hybridization Chain Reaction.

The association between microRNA (miRNA) and various diseases has been established; miRNAs have the potential to be biomarkers for these diseases. Nevertheless, the challenge of correctly quantifying an miRNA arises from its low abundance and a high degree of family homology. Therefore, in the present study, we devised a chemiluminescence (CL) detection method for miRNAs, known as the hybridization chain reaction (HCR)-CL, utilizing the enzyme-free signal amplification technology of HCR.

Classification of Chicken Carcass Breast Blood-Related Defects Using Hyperspectral Imaging Combined with Convolutional Neural Networks.

For chicken carcass breast blood-related defects (CBDs), which occur with high frequency, the visual features are approximated in terms of the similarity of the composition of these defects, making it challenging to classify them, either manually or automatically, using conventional machine vision. The aim of this paper was to introduce a method of CBD classification based on hyperspectral imaging combined with Convolutional Neural Networks (CNNs). To process hyperspectral data, the Improved Firefly Band Selection Algorithm was constructed with the 1-D CNN CBD classification model as the objective function, achieving a reduction in the dimensionality of hyperspectral data.

Human Preferences for Dogs and Cats in China: The Current Situation and Influencing Factors of Watching Online Videos and Pet Ownership.

Dogs and cats have become the most important and successful pets through long-term domestication. People keep them for various reasons, such as their functional roles or for physical or psychological support. However, why humans are so attached to dogs and cats remains unclear.

Complementary Approaches to Postoperative Pain Management: A Review of Non-pharmacological Interventions.

Postoperative pain significantly affects many surgical patients. While opioids are crucial for pain management, they come with unwanted side effects. Alternatives like nonsteroidal anti-inflammatory drugs, N-methyl-D-aspartate (NMDA) receptor antagonists, and regional anesthesia techniques such as nerve blocks are utilized, but these also have limitations.

Statistical shape models quantify acetabular defects in hip revision surgery: implications for classification and surgical planning.

Purpose: The purposes of this study was to develop a novel therapy-oriented acetabular bone defects classification system based on Statistical shape models (SSMs) and evaluate the reliability and reproducibility of its application.

Methods: We retrospectively reviewed and annotated pelvic Computed tomography (CT) of patients who had undergone revision total hip arthroplasty at our institution and constructed a dataset to develop the novel method for quantitatively describing acetabular bone defects that is based on SSMs. Then, using this method, classification systems are suggestive for diagnosis and corresponding treatment suggestion.

Effects of ionic strength, cation type and pH on the cotransport of microplastics with PFOA in saturated porous media.

Both perfluorooctanoic acid (PFOA) and polystyrene microplastics (PS-MPs) are emerging contaminants commonly found in aqueous environments. In co-contaminated areas, MPs may act as carriers for PFOA, complicating transport dynamics. However, information on their cotransport in porous media is limited.

Pioglitazone Modulates Microglia M1/M2 Polarization Through PPAR-γ Pathway and Exerts Neuroprotective Effects in Experimental Subarachnoid Hemorrhage.

Subarachnoid hemorrhage (SAH), a subtype of hemorrhagic stroke primarily resulting from the rupture of intracranial aneurysms, remains a significant contributor to disability and mortality, notwithstanding advancements in treatment. This study investigates the neuroprotective effects of pioglitazone in SAH, focusing on the PPAR-γ pathway and its potential role in mitigating early brain injury (EBI) following SAH. Neuroprotective efficacy was assessed through neurobehavioral assessment, brain water content analysis, TUNEL, immunofluorescence, western blotting, and inflammatory factor assay.

Human Brain Organoids Model Abnormal Prenatal Neural Development Induced by Thermal Stimulation.

The developing human foetal brain is sensitive to thermal stimulation during pregnancy. However, the mechanisms by which heat exposure affects human foetal brain development remain unclear, largely due to the lack of appropriate research models for studying thermal stimulation. To address this, we have developed a periodic heating model based on brain organoids derived from human pluripotent stem cells.

Comparative Analysis of Gut Microbiota Between Wild and Captive Guizhou Snub-Nosed Monkey ().

Maintaining a healthy status is crucial for the successful captive breeding of critically endangered , it is conducive to ex situ conservation of this species and rejuvenation of its population. However, changes in the feeding environment and food can affect the composition and function of the gut microbiota in , ultimately impacting its health and adaptation. Herein, 16S rRNA gene sequencing was employed to determine the gut microbiota composition and functional variations between wild and captive populations.

Anti-ultraviolet and semi-durable flame-retardant viscose fabrics fabricated by modified tea polyphenols.

Viscose fabrics are characterized as good moisture absorption and dyeability, but the disadvantage of being extremely flammable limits the application of viscose fabrics. In this paper, tea polyphenols (TPs), amino trimethylphosphonic acid (ATMP) and urea were used to synthesize a semi-durable and efficient flame retardant, TBP. The limiting oxygen index (LOI) of Viscose/TBP was 44.

Manipulation of Unconventional Spin Polarization in Non-Collinear Exchange-Spring Magnetic Structures.

Manipulating the polarization of spin current is essential for understanding the mechanism of charge-to-spin conversion and achieving efficient electrically driven magnetization switching. Here, a novel exchange-spring magnetic structure is introduced formed by the coupling of perpendicular magnetic anisotropy (PMA) CoTb and in-plane magnetic anisotropy (IMA) Co films. When a spin current with the polarization along the y-direction flows through this exchange-spring (x-z plane) structure, the interaction between the y-spin and the local exchange field with a non-collinear spatial distribution gives rise to substantial unconventional spin polarizations in the x- and z-directions, enabling field-free spin-orbit torque driven perpendicular magnetization switching at room temperature.