METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism.

Type 2 diabetes (T2D) is characterized by lack of insulin, insulin resistance and high blood sugar. However, the underlying mechanisms of insulin resistance during T2D development remains unclear. As the most common mRNAs modification, N6-Methyladenosine (m6A) is involved in many of pathological processes in aging disease.

Adapting the RUSLE and GIS to model soil erosion risk in a mountains karst watershed, Guizhou Province, China.

Soil erosion is a serious environmental problem in Guizhou Province, which is located in the centre of the karst areas of southwestern China. Unfortunately, Guizhou Province suffers from a lack of financial resources to research, monitor and model soil erosion at large watershed. In order to assess the soil erosion risk, soil erosion modeling at the watershed scale are urgently needed to be undertaken.

[Changes of intercellular adhesion molecule-1 and E-selectin levels in plasma of uremic patients treated with maintaining hemodialysis].

Aim: To detect the levels of ICAM-1 and E-selectin in plasmas from uremic patients treated by means of maintaining hemodialysis (MHD) and explore the pathological mechanism of atherosclerosis in MHD patients.

Methods: The levels of ICAM-1 and E-selectin in plasmas from the 105 MHD patients and 25 healthy persons (control group) were detected by dual antibody sandwich ELISA. The cervical atherosclerosis of the patients was examined by type B ultrasonography.

[The effect of continuous high-volume hemofiltration therapy on TNF-alpha of pancreatitis patients complicated with acute renal function failure].

Aim: To explore the role of continuous high-volume renal replacement therapy(HV-CRRT) in serum TNF-alpha removal.

Methods: 13 panceatitis patients complicated with acute renal failure were treated by continuous venovenous hemofiltration (CVVH), and they were divided into two groups according to the substitution rate during CVVH. The substitution rate of group I (8 cases) was 2 L/h, the that of group II(5 cases) was 4 L/h.

[The significance of fluorescent patterns of antineutrophil cytoplasmic antibodies (ANCA) in renal diseases].

Aim: To further explore significance of fluorescent patterns of antineutrophil cytoplasmic antibodies in renal diseases.

Methods: ANCA fluorescent patterns and its target antigens in sera of 251 patients with renal diseases were detected by indirect immunofluorescence (IIF) and ELISA.

Results: The positive percentage of ANCA is 20.