Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches with Antimicrobial and Immunomodulating Properties for Oral Mucosa Disease Treatment.

Oral ulcer wounds are difficult to heal due to bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal of ROS, and reduction of inflammation are prerequisites for the treatment of mouth ulcer wounds. In this study, oligomeric proanthocyanidins (OPC) and 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used to form polymer gels through dynamic covalent borate bonds.

Synthesis of IrCu/CoO hybrid nanostructures and their enhanced catalytic properties toward oxygen evolution reaction under both acidic and alkaline conditions.

Oxygen evolution reaction (OER) is a half-reaction that occurs at the anode during water electrolysis, and owing to its slow kinetics, it is the rate-limiting step in the process. Alloying with transition metal and combining with transition metal oxide supports are effective methods for modifying the electronic structure of noble metal catalysts and improving their catalytic properties. In this study, we synthesized IrCu/CoO hybrid nanostructures by attaching IrCu alloy nanoparticles onto CoO nanosheets.

Effectiveness of Cognitive Rehabilitation in Improving Symptoms and Restoring Cognitive Functions in Patients with Depression: An Updated Meta-Analysis of Randomized Controlled Trials.

Objective: Patients with depression often experience cognitive impairments. Cognitive rehabilitation, as an adjunctive intervention, may help to improve symptoms and restore functions in these patients. This study explores the effectiveness of cognitive rehabilitation in improving symptoms and restoring cognitive functions in patients with depression.

Overview of Phage Defense Systems in Bacteria and Their Applications.

As natural parasites of bacteria, phages have greatly contributed to bacterial evolution owing to their persistent threat. Diverse phage resistance systems have been developed in bacteria during the coevolutionary process with phages. Conversely, phage contamination has a devastating effect on microbial fermentation, resulting in fermentation failure and substantial economic loss.

Old but not ancient: Rock-leached organic carbon drives groundwater microbiomes.

More than 90% of earth's microbial biomass resides in the continental subsurface, where sedimentary rocks provide the largest source of organic carbon (C). While many studies indicate microbial utilization of fossil C sources, the extent to which rock-organic C is driving microbial activities in aquifers remains largely unknown. Here we incubated oxic and anoxic groundwater with crushed carbonate rocks from the host aquifer and an outcrop rock of the unsaturated zone characterized by higher organic C content, and compared the natural abundance of radiocarbon (C) of available C pools and microbial biomarkers.

Machine learning for the prediction of mortality in patients with sepsis-associated acute kidney injury: a systematic review and meta-analysis.

Background: Predicting mortality in sepsis-related acute kidney injury facilitates early data-driven treatment decisions. Machine learning is predicting mortality in S-AKI in a growing number of studies. Therefore, we conducted this systematic review and meta-analysis to investigate the predictive value of machine learning for mortality in patients with septic acute kidney injury.

Application of Bacillus cereus for synthesis of polyhydroxyalkanoates from industrial corn starch residue.

Starch hydrolysate from corn is typically employed as a carbon source for citric acid production by Aspergillus niger. Enzymatic or acid hydrolysis of corn starch generates a corn starch residue (CSR), which represents a potential bio-fermentation carbon source. In addition, polyhydroxyalkanoates (PHAs) can be used as an alternative to traditional petrochemical plastics.

NEDD4's effect on osteoblastogenesis potential of bone mesenchymal stem cells in rats concerned with PI3K/Akt pathway.

Neural precursor cell expressed developmentally down-regulated 4 (NEDD4) is an E3 ubiquitin ligase implicated in craniofacial development. Emerging evidence suggests that NEDD4 may down-regulates Akt signaling, a key element of the PI3K/Akt pathway involved in cell differentiation. This study aimed to investigate NEDD4's role in bone mesenchymal stem cells (BMSCs) differentiation and its interaction with the PI3K/Akt pathway.

Single-cell sequencing decodes the secrets of the RAP phenomenon of corticotomy.

Introduction: Corticotomy-assisted tooth movement is commonly performed in clinics, however, its time-limited efficacy and the fear of surgery among patients significantly limit its clinical application. Hence, researchers have investigated non-invasive methods to accelerate tooth movement. However, the molecular mechanisms underlying corticotomy-assisted tooth movement are not fully understood.

Effect of External Ventricular Drainage on Shunt-Dependent Hydrocephalus and Prognosis After Microsurgical Clipping in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage.

Objective: In poor-grade aneurysm subarachnoid hemorrhage (PaSAH), the use of external ventricular drainage (EVD) may be closely related to the occurrence of shunt-dependent hydrocephalus (SDHC). The purpose of this study was to investigate the effect of EVD on SDHC and prognosis after microsurgically clipping patients with PaSAH.

Methods: The clinical data of 99 patients with PaSAH admitted to the 904th Hospital of People's Liberation Army from October 2011 to December 2020 were analyzed retrospectively.

The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study.

Background: Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer's disease (AD) pathology. Multiple p-tau biomarkers on several analytical platforms are poised for clinical use. The Alzheimer's Association Global Biomarker Standardisation Consortium plasma phospho-tau Round Robin study engaged assay developers in a blinded case-control study on plasma p-tau, aiming to learn which assays provide the largest fold-changes in AD compared to non-AD, have the strongest relationship between plasma and cerebrospinal fluid (CSF), and show the most consistent relationships between methods (commutability) in measuring both patient samples and candidate reference materials (CRM).

Anti-inflammatory effects and related mechanisms of naringenin in human periodontal ligament stem cells under lipopolysaccharide stimulation based on RNA sequencing.

Objectives: RNA sequencing (RNA-seq) and bioinformatic analysis were combined and used to explore the anti-inflammatory effects and mechanisms of naringenin (Nar) in lipopolysaccharide (LPS)-stimulated human periodontal ligament stem cells (hPDLSCs).

Methods: Cell counting kit-8, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and enzyme-linked immunosorbent assay (ELISA) were adopted to detect the effects of Nar on the proliferation and expression of inflammatory factors in LPS-stimulated hPDLSCs, screening for the optimal anti-inflammatory concentration of Nar. Differentially expressed genes (DEGs) were screened using |log2FC|≥1 and ≤0.

Naringenin modulates the NO‑cGMP‑PKG signaling pathway by binding to AKT to enhance osteogenic differentiation in hPDLSCs.

Naringenin (NAR) is a prominent flavanone that has been recognized for its capacity to promote the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). The present study aimed to explore how NAR promotes the osteogenic differentiation of hPDLSCs and to assess its efficacy in repairing alveolar bone defects. For this purpose, a protein‑protein interaction network of NAR action was established by mRNA sequencing and network pharmacological analysis.

Feasible and economic DIY procedures of a hand-held fluorescence detector set-FluorDetector to assist laboratory course development.

Fluorescence-related experimental techniques play an important role in biochemistry, molecular biology, and cell biology. However, fluorescence-related experiments are rarely included in the laboratory courses of most Chinese universities. This is mainly due to the conflict between large class size (50-60 students in one room) and funding/space limitations to purchase and accommodate enough fluorescence detection equipment.

Facile synthesis of AuIr alloy nanoparticles and their enhanced oxygen evolution reaction performance under acidic and alkaline conditions.

The development of electrocatalysts that can maintain high reactivity and stability over a wide pH range during electrolysis reactions is essential for the realization of a clean hydrogen energy society. Herein, we report the synthesis of AuIr alloy nanoparticles (NPs) with an excellent oxygen evolution reaction (OER) performance over a wide pH range. The NPs were synthesized an antisolvent crystallization-based method and maintained their small sizes regardless of adjustments in the ratio of the Au/Ir precursor.

Properties and Fungal Communities of Different Soils for Growth of the Medicinal Asian Water Plantain, , in Fujian, China.

The Asian water plantain, (Sam.) Juzep, is a traditional Chinese medicinal plant. The dried tubers of the , commonly referred to as (AR), have long been used in traditional Chinese medicine to treat a variety of diseases.

CoCl-Induced hypoxia promotes hPDLSCs osteogenic differentiation through AKT/mTOR/4EBP-1/HIF-1α signaling and facilitates the repair of alveolar bone defects.

Bone defects are characterized by a hypoxic environment, which affects bone tissue repair. However, the role of hypoxia in the repair of alveolar bone defects remains unclear. Human periodontal ligament stem cells (hPDLSCs) are high-quality seed cells for repairing alveolar bone defects, whose behavior changes under hypoxia.

Antifungal mechanism of rose, mustard, and their blended essential oils against Cladosporium allicinum isolated from Xinjiang naan and its storage application.

Aims: To reveal the inhibition mechanism of rose, mustard, and blended essential oils against Cladosporium allicinum isolated from Xinjiang naan, and investigate the effect of the three essential oils on oxidative damage and energy metabolism.

Methods And Results: Rose and mustard essential oils significantly inhibited mycelial growth and spore viability in a dose-dependent relationship. After essential oil treatment, the cell membrane permeability was altered, and significant leakage of intracellular proteins and nucleic acids occurred.

NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.

The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we address these challenges with NUcleic acid Linked Immuno-Sandwich Assay (NULISA™), which improves the sensitivity of traditional proximity ligation assays by ~10,000-fold to attomolar level, by suppressing assay background via a dual capture and release mechanism built into oligonucleotide-conjugated antibodies. Highly multiplexed quantification of both low- and high-abundance proteins spanning a wide dynamic range is achieved by attenuating signals from abundant targets with unconjugated antibodies and next-generation sequencing of barcoded reporter DNA.

Advances in Tunable Bandgaps of Piezoelectric Phononic Crystals.

Bandgaps of traditional phononic crystals (PCs) are determined using structural geometric parameters and material properties, and they are difficult to tune in practical applications. Piezoelectric PCs with lead zirconium titanate piezoelectric ceramics (abbreviated to piezoelectric PCs) have multi-physics coupling effects and their bandgaps can be tuned through external circuits to expand the application range of the PCs. First, the typical structures of piezoelectric PCs are summarized and analyzed.

Analysis of spatial-temporal pattern, dynamic evolution and influencing factors of health tourism development in China.

The evaluation index system is constructed based on the connotation and characteristics of health tourism. Using the entropy method, Thiel index, exploratory spatial data analysis method, spatial Markov chain and spatial econometric model, research is carried out around the development index, difference status, spatial-temporal pattern, dynamic evolution and influencing factors of health tourism. The following results were drawn: (1) The development index of health tourism in China is low, but the development speed is fast.