Publications by authors named "Xu Xiaoli"

China is grappling with significant aging challenge, and food patterns play an important role in the health of aging populations. A comprehensive bibliometric analysis with regard to systematically examined population-based studies published between 1 June 2014 and 31 May 2024, and 83 eligible studies, including 43 cross-sectional, 34 longitudinal, and 6 case-control studies, was conducted to investigate the correlations among foods, dietary patterns, and healthy aging concepts. An interesting conclusion from cohort studies was that foods recommended for intake in certain diets might not be recommended in other diets, i.

View Article and Find Full Text PDF

Aim: We aimed to identify the characteristics of patients with diabetes who can derive cognitive benefits from intensive blood pressure (BP) treatment using machine learning methods.

Materials And Methods: Using data from the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) study, 1349 patients with type 2 diabetes who underwent BP treatment (intensive treatment targeting a systolic BP <120 mmHg vs. standard treatment targeting <140 mmHg) were included in the machine learning analysis.

View Article and Find Full Text PDF

Purpose: To explore the recurrence pattern and risk factors associated with the relapse of thoracic esophageal squamous cell carcinoma (TESCC) among patients who received esophagectomy following neoadjuvant immunochemotherapy (NICT).

Methods: A total of 191 TESCC patients who received esophagectomy following NICT were retrospectively reviewed from 2019 to 2022. The first recurrence patterns were assessed.

View Article and Find Full Text PDF

, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. In this study, we conducted a genetic screen to identify novel genes that regulate biofilm formation in .

View Article and Find Full Text PDF

Understanding the enhancing mechanisms of graphene oxide (GO) on the pore structure characteristics in the interfacial transition zone (ITZ) plays a crucial role in cemented waste rock backfill (CWRB) nanoreinforcement. In the present work, an innovative method based on metal intrusion techniques, backscattered electron (BSE) images, and deep learning is proposed to analyze the micro/nanoscale characteristics of microstructures in the GO-enhanced ITZ. The results showed that the addition of GO reduced the interpore connectivity and the porosity at different pore throats by 53.

View Article and Find Full Text PDF

Introduction: Arbuscular mycorrhizal fungi (AMF) can relieve manganese (Mn) phytotoxicity and promote plant growth under Mn stress, but their roles remain unclear.

Methods: In this study, inoculated with or without AMF () under different Mn concentrations (0 mmol/L, 1 mmol/L, 5 mmol/L, 10 mmol/L, and 20 mmol/L) was cultivated via a pot experiment, and plant biomass, physiological and biochemical characteristics, manganese absorption, subcellular distribution, and chemical forms of Mn were examined.

Results: The results showed that root biomass, stem biomass, leaf biomass, and total individual biomass decreased under high Mn concentrations (above 10 mmol/L), and the inoculated plants had higher biomass than the uninoculated plants.

View Article and Find Full Text PDF

Background: Ectopic cortisol-producing adrenocortical adenoma (ECPA) is extremely rare, with only a few cases reported. Retroperitoneal schwannoma is also uncommon, accounting for only 0.7-5% of all schwannomas.

View Article and Find Full Text PDF

To explore role of NAALADL2-AS2 as ceRNA in DLBCL. Fluorescence in situ hybridization was used to determine location of NAALADL2-AS2 in cells and to verify its expression in DLBCL tissues. The miRNAs interacting with NAALADL2-AS2 and related regulatory genes were identified by small interfering RNA (siRNA) assay, luciferase reporter assay, fluorescent quantitative polymerase chain reaction, western blotting.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers are exploring the role of stromal cells, such as fibroblasts, vascular endothelial cells (VECs), and smooth muscle cells (VSMCs), in the inflammation associated with psoriasis, a skin disease whose causes are not fully understood.
  • A comprehensive analysis of skin samples from psoriasis patients revealed distinct types of fibroblasts, VECs, and VSMCs that are more prevalent in lesional skin, indicating a shift towards inflammatory and angiogenesis-promoting activities in these cells.
  • The study concludes that the interactions between these stromal cells contribute to the pathological changes in psoriasis vulgaris, suggesting that targeting these cells may help improve the inflammatory environment associated with the disease.
View Article and Find Full Text PDF
Article Synopsis
  • - High temperatures are crucial for forming stable α-FAPbI films but can also cause the loss of organic materials in perovskites.
  • - A new method using a 300 °C hot-press technique effectively creates high-quality α-FAPbI films without additives, enhancing grain size and reducing strain.
  • - The resulting solar cells achieve a high power conversion efficiency of 24.06% and maintain over 70% efficiency after extended exposure to challenging conditions (85°C and 85% humidity) for 1000 hours.
View Article and Find Full Text PDF

Background: The purpose of this study was to evaluate the repeatability and agreement of multispectral refraction topography (MRT) in measuring retinal refraction before and after cycloplegia in children. The results of this study will provide valuable insights into the accuracy and reliability of MRT as a tool for assessing retinal refraction in pediatric patients.

Methods: Children aged 7 to 18 years old were recruited for this prospective research.

View Article and Find Full Text PDF

T-2 toxin, a fungal secondary metabolite produced by toxigenic species, poses a significant threat to grain food and feed due to its potential to cause intestinal inflammation in livestock and poultry. Macrophages play a crucial role as integral components of the body's immune system during intestinal inflammation. This study aimed to elucidate the mechanism behind the inflammatory response triggered by T-2 toxin in macrophages.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effects of repetitive peripheral magnetic stimulation (rPMS) on respiratory muscle and lung function in stroke patients, specifically focusing on its impact on the diaphragm and phrenic nerve.
  • It employs a randomized controlled trial design, comparing rPMS with conventional rehabilitation in a group of 30 patients, evaluating outcomes such as respiratory muscle strength and diaphragm thickness over two weeks of treatment.
  • Ethical approval is secured, and participants will receive thorough information about the study and provide informed consent before beginning the trial.
View Article and Find Full Text PDF

Background: We aimed to explore the association between visit-to-visit systolic blood pressure variability (BPV) and cognitive function in individuals with type 2 diabetes.

Methods: We performed a post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) substudy. A total of 2867 diabetes patients with ≥3 BP measurements between the 4- and 20-month visits were included.

View Article and Find Full Text PDF
Article Synopsis
  • RNA editing, particularly A-to-I editing, plays a key role in processes such as stem cell differentiation and muscle development, making it crucial to understand these mechanisms in skeletal muscle satellite cells (MuSCs).* -
  • A study screened 9,632 RNA editing sites in various muscle cell stages, identifying 4,559 A-to-I edits, with significant edits found in protein-coding regions and specific pathways linked to muscle function.* -
  • The research highlighted 14 hub genes related to muscle development and discovered 123 stage-specific A-to-I editing sites, revealing essential biological pathways involved in muscle cell proliferation and differentiation.*
View Article and Find Full Text PDF
Article Synopsis
  • ADAR1 is a key regulator of skeletal muscle and affects various physiological processes, but its specific role in muscle growth, particularly in goats, needs more research.
  • The study found that ADAR1 is more abundant in certain goat muscles and enhances the growth and differentiation of muscle satellite cells (MuSCs) when overexpressed.
  • Analysis revealed that knocking down ADAR1 led to significant changes in gene expression linked to muscle development, with important genes identified that are involved in the myogenic process.
View Article and Find Full Text PDF

Traditional imaging methods have limitations in the diagnosis of peripheral lung lesions. The aim of this study is to evaluate the diagnostic value of the distance measurement method based on ultrasound image-based inverted electrostrain (rEBUS) combined with thoracoscopic lung biopsy (TBLB) for peripheral lung lesions. A group of patients with peripheral lung lesions were recruited for the study, and rEBUS examination was performed simultaneously during TBLB.

View Article and Find Full Text PDF

Submandibular gland (SMG) excision via axillary is a brand new technique and we presented its own unique advantages compared with retroauricular and transoral approaches. The single-port (SP) robotic system offers improved visualization of the view and enhanced flexibility of instruments, ensuring optimal stability and dissection in this surgery. We reported the first case of transaxillary SMG excision using single-port robotic system made in China.

View Article and Find Full Text PDF
Article Synopsis
  • Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges, motivating research into the molecular mechanisms behind it.
  • This study specifically examines changes in the epigenetic landscape and the role of super-enhancers during the development of resistance to the chemotherapy drug gemcitabine.
  • Key findings include the identification of deactivation of the NDRG1 super-enhancer, which leads to WNT/β-catenin signaling activation, contributing to gemcitabine resistance and highlighting potential therapeutic targets for overcoming this resistance in PDAC.
View Article and Find Full Text PDF

Objective: This study aimed to determine the prevalence of hearing loss and identify associated risk factors in a Chinese population aged 45 years and older.

Study Design: This study employed a cross-sectional research design. Data from the 4th wave survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2018 were utilized.

View Article and Find Full Text PDF

Hyperuricemia, a major worldwide burden on public hygiene, is closely connected with dietary habits. However, few studies have evaluated the association of dietary diversity with hyperuricemia. To preliminarily reveal the status of a diversified diet in preventing hyperuricemia based on a neighborhood-based, massive-scale cohort in China, a total of 43,493 participants aged 20-74 years old, with no history of hyperuricemia at baseline, were enrolled in the research from April 2016 to December 2019.

View Article and Find Full Text PDF
Article Synopsis
  • Protein-protein interactions (PPIs) are essential for biological functions and are linked to various human diseases, making them important targets for drug development.
  • The cGAS-STING pathway is crucial for regulating the immune system and is associated with several health issues, drawing significant research interest in its modulators.
  • This review highlights recent progress in drug discovery related to cGAS-STING PPIs and suggests new strategies for developing potential treatments targeting this pathway.
View Article and Find Full Text PDF

Objectives: We explored Trichorhinophalangeal syndrome type 1 (TRPS1) expression in special types of breast carcinoma, and analyzed the correlation between TRPS1 and androgen receptor (AR) expression in triple-negative breast cancer (TNBC).

Methods: TRPS1 expression was analyzed in 801 patients with special types of breast carcinoma. A total of 969 TNBC were used to analyze the correlation between the expression of TRPS1 and AR.

View Article and Find Full Text PDF
Article Synopsis
  • Thyroid hormone is essential for many bodily functions, while α-Klotho is associated with aging and metabolic regulation; the study explores their relationship.
  • Researchers analyzed data from 4,614 adults from the NHANES database (2007-2012) using statistical models to examine how α-Klotho levels relate to thyroid hormone levels.
  • The findings indicate that higher α-Klotho levels correlate with increased FT3, TT3, and TT4 levels, but are linked to lower TSH levels, suggesting that α-Klotho could serve as a potential marker for thyroid function.
View Article and Find Full Text PDF