Interleukin-37 and Dendritic Cells Treated With Interleukin-37 Plus Troponin I Ameliorate Cardiac Remodeling After Myocardial Infarction.

Background: Excessive immune-mediated inflammatory reactions play a deleterious role in postinfarction ventricular remodeling. Interleukin-37 (IL-37) emerges as an inhibitor of both innate and adaptive immunity. However, the exact role of IL-37 and IL-37 plus troponin I (TnI)-treated dendritic cells (DCs) in ventricular remodeling after myocardial infarction (MI) remains elusive.

Effect of different levels of corn steep liquor addition on fermentation characteristics and aerobic stability of fresh rice straw silage.

The object of this study was to determine the proper mixing ratio of fresh rice straw to corn steep liquor (CSL) to obtain a high protein content silage feed. The following experimental silages were generated: the control (C1), composed of fresh rice straw without CSL additive, mixed with CSL in the ratios of 4:1 (C4), 3:1 (C3) and 2:1 (C2). Lactic acid bacteria (LAB) inoculant was applied at the rate of 50 mL/kg (fresh basis) of forage to achieve a final application rate of 1 × 10 cfu/g of fresh matter (FM).

Diagnosis and surgical management of insulinomas in 33 consecutive patients at a single institution.

Purpose: The purpose of this study was to evaluate the diagnosis and surgical management of insulinomas in a single-center setting.

Methods: Demographic details, clinical presentation, preoperative diagnosis, surgical strategy, and outcomes of 33 consecutive patients who underwent surgery for insulinoma were analyzed retrospectively.

Results: The median time from the first onset of symptoms to diagnosis was 24 months (range 3 days to 50 years).

Multifidus Muscle Atrophy Not Observed Following Two-segment Anterior Interbody Fusion: A Rabbit Model Study With a 12-Month Follow-up.

Study Design: Experimental study evaluated magnetic resonance imaging (MRI) and histologic changes in the multifidus muscle after anterior spinal fusion.

Objective: To determine the effect of spinal fusion on the multifidus muscle in an anterior rabbit model through the use of MRI and histologic evaluation.

Summary Of Background Data: Retraction and splitting approach are known to be important factors in postoperative injury and atrophy of the multifidus muscle.

Effects of ruminally degradable starch levels on performance, nitrogen balance, and nutrient digestibility in dairy cows fed low corn-based starch diets.

Objective: This trial was performed to examine the effects of ruminally degradable starch (RDS) levels in total mixed ration (TMR) with low corn-based starch on the milk production, whole-tract nutrient digestibility and nitrogen balance in dairy cows.

Methods: Eight multiparous Holstein cows (body weight [BW]: 717±63 kg; days in milk [DIM]: 169±29) were assigned to a crossover design with two dietary treatments: a diet containing 62.3% ruminally degradable starch (% of total starch, low RDS) or 72.

Selection of a marker gene to construct a reference library for wetland plants, and the application of metabarcoding to analyze the diet of wintering herbivorous waterbirds.

Food availability and diet selection are important factors influencing the abundance and distribution of wild waterbirds. In order to better understand changes in waterbird population, it is essential to figure out what they feed on. However, analyzing their diet could be difficult and inefficient using traditional methods such as microhistologic observation.

Effects of applying lactic acid bacteria to the fermentation on a mixture of corn steep liquor and air-dried rice straw.

This study was to determine the fermentation quality of a mixture of corn steep liquor (CSL) (178 g/kg wet basis) and air-dried rice straw (356 g/kg wet basis) after being treated with inoculants of different types of lactic acid bacteria (LAB). The treatments included the addition of no LAB additive (control), which was deionized water; homo-fermentative LAB alone (LAB), which was alone), and a mixture of homo-fermentative and hetero-fermentative LAB (LAB), which were , , and . The results showed that the inoculation of the mixture of CSL and air-dried rice straw with LAB significantly increased the concentration of acetic acid and lactic acid compared with the control ( < 0.

Oblique rift opening revealed by reoccurring magma injection in central Iceland.

Extension deficit builds up over centuries at divergent plate boundaries and is recurrently removed during rifting events, accompanied by magma intrusions and transient metre-scale deformation. However, information on transient near-field deformation has rarely been captured, hindering progress in understanding rifting mechanisms and evolution. Here we show new evidence of oblique rift opening during a rifting event influenced by pre-existing fractures and two centuries of extension deficit accumulation.

Novel phosphatidylinositol 3-kinase inhibitor BKM120 enhances the sensitivity of multiple myeloma to bortezomib and overcomes resistance.

Proteasome inhibitor bortezomib has proven efficacy against multiple myeloma. However, bortezomib activates the phosphatidylinositol 3-kinase/AKT (PI3K/AKT) pathway (which is essential to the development of myeloma), often resulting in drug resistance and disease recurrence. The addition of BKM120 significantly enhanced the apoptotic effects of bortezomib in both bortezomib-sensitive and bortezomib-resistant cells.

Developmental neurotoxicity of organophosphate flame retardants in early life stages of Japanese medaka (Oryzias latipes).

Because brominated flame retardants are being banned or phased out worldwide, organophosphate flame retardants have been used as alternatives on a large scale and have thus become ubiquitous environmental contaminants; this raises great concerns about their environmental health risk and toxicity. Considering that previous research has identified the nervous system as a sensitive target, Japanese medaka were used as an aquatic organism model to evaluate the developmental neurotoxicity of 4 organophosphate flame retardants: triphenyl phosphate, tri-n-butyl phosphate, tris(2-butoxyethyl) phosphate, and tris(2-chloroethyl) phosphate (TCEP). The embryo toxicity test showed that organophosphate flame retardant exposure could decrease hatchability, delay time to hatching, increase the occurrence of malformations, reduce body length, and slow heart rate.

Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity.

With the gradual ban on brominated flame retardants (FRs), the application of organophosphate flame retardants (OPFRs) has increased remarkably. Considering the structural similarity between OPFRs and organophosphate pesticides, hypotheses that OPFRs may interfere with neurodevelopment as organophosphate pesticides are reasonable. In this study, the neurotoxicity of three OPFRs, including tri-n-butyl phosphate (TNBP), tris (2-butoxyethyl) phosphate (TBOEP) and tris (2-chloroethyl) phosphate (TCEP), was evaluated in zebrafish larvae and then compared with the neurotoxicity of organophosphate pesticide chlorpyrifos (CPF).

Gradient Permittivity Meta-Structure model for Wide-field Super-resolution imaging with a sub-45 nm resolution.

A gradient permittivity meta-structure (GPMS) model and its application in super-resolution imaging were proposed and discussed in this work. The proposed GPMS consists of alternate metallic and dielectric films with a gradient permittivity which can support surface plasmons (SPs) standing wave interference patterns with a super resolution. By employing the rigorous numerical FDTD simulation method, the GPMS was carefully simulated to find that the period of the SPs interference pattern is only 84 nm for a 532 nm incident light.

50 μm core diameter Yb³⁺Al³⁺/F⁻ codoped silica fiber with M²<1.1 beam quality.

This paper reports, for the first time to our best knowledge, a nearly diffraction-limited output in a Yb(3+)/Al(3+)/F(-) codoped double cladding silica fiber with a 50 μm core diameter and 0.02 core NA. The core glass with a diameter >6  mm was fabricated through solgel process combined with high temperature sintering.

Rapid Identification of Flavonoid Constituents Directly from PTP1B Inhibitive Extract of Raspberry (Rubus idaeus L.) Leaves by HPLC-ESI-QTOF-MS-MS.

Many potential health benefits of raspberry (Rubus idaeus L.) leaves were attributed to polyphenolic compounds, especially flavonoids. In this study, the methanol extract of R.

Effect of pure muscle retraction on multifidus injury and atrophy after posterior lumbar spine surgery with 24 weeks observation in a rabbit model.

Purpose: To evaluate the effect of pure muscle retraction on multifidus injury and atrophy.

Materials And Methods: Sixty-three adult New Zealand white rabbits were divided evenly into three groups: 1-h retraction (group R1), 2-h retraction (R2), and sham surgery (C). The multifidus muscle was evaluated using magnetic resonance imaging (MRI) and histology after 3 and 48 h, and 1, 3, 6, 12, and 24 weeks after surgery.

[Study on Spectral Characteristics of Two Kinds of Home-Made Novel Yb-Doped Fluoride Laser Crystals].

Yb-doped fluoride crystals are of important another Yb-doped laser materials besides Yb-doped oxide, which are becoming one of interests for developing tunable lasers and ultrafast lasers. In this paper, the systematic and contrastive experiments of the optical spectral characteristics are presented for two types of home-made novel Yb-doped fluoride laser crystals, namely, Yb-doped CaF2-SrF2 mixed crystal and co-doped Yb, Y:CaF2 single crystal. The fluorescent features of Yb-doped CaF2-SrF2 mixed crystal and co-doped Yb, Y:CaF2 single crystal are apparently different by the fluorescence experiment.

The CO2 Storage Capacity of the Intercalated Diaminoalkane Graphene Oxides: A Combination of Experimental and Simulation Studies.

To study the effect of interlayer spacing of pillared graphene oxides (GOs) on CO2 uptake, we have obtained CO2 isotherms with respect to the interlayer distance of pillared graphene oxide by both experimental and simulation methods. Interlayer distances of GO were modulated by intercalation of three kinds of diaminoalkanes with a different number of carbon atoms (NH2(CH2) n NH2, n = 4, 8, and 12) as pillars. The intercalated GOs (IGOs) and their reduced products (RIGOs) are characterized using a variety of approaches such as X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and N2 adsorption.

Modified One-layer Duct-to-mucosa Pancreaticojejunostomy Reduces Pancreatic Fistula After Pancreaticoduodenectomy.

Postoperative pancreatic fistula (POPF) is a major source of morbidity after pancreaticoduodenectomy (PD). The purpose of this retrospective study comparing one-layer pancreaticojejunostomy (PJ) with two-layer PJ after PD was to evaluate whether the one-layer duct-to-mucosa PJ after PD can reduce the incidence of POPF.A total of 194 consecutive patients who underwent PD by one surgeon (Y.

Birth of two volcanic islands in the southern Red Sea.

Submarine eruptions that lead to the formation of new volcanic islands are rare and far from being fully understood; only a few such eruptions have been witnessed since Surtsey Island emerged to the south of Iceland in the 1960s. Here we report on two new volcanic islands that were formed in the Zubair archipelago of the southern Red Sea in 2011-2013. Using high-resolution optical satellite images, we find that the new islands grew rapidly during their initial eruptive phases and that coastal erosion significantly modified their shapes within months.

Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling.

Background: Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to the pathogenesis of certain diseases including cancers, especially acute promyelocytic leukemia (APL). Recently, oridonin, a natural diterpenoid isolated from Rabdosia rubescens, was demonstrated to regulate RARα by increasing its protein level. However, the underlying molecular mechanism for this action has not been fully elucidated.

Nonspecific interstitial pneumonia: clinical associations and outcomes.

Background: Studies have shown that nonspecific interstitial pneumonitis (NSIP), even when initially diagnosed as an idiopathic form of the disease, might be associated with an autoimmune background that later reveals itself as an organ-specific or a systemic autoimmune disease.

Methods: NSIP patients were divided into three groups. The NSIP patients who met the criteria for having a systemic autoimmune disease (SAD) were defined as the systemic autoimmune disease-associated NSIP (SAD-NSIP) group.

[Clinical features and prognostic analysis of 75 primary myelofibrosis patients].

Objective: To investigate the clinical and hematological features and prognostic factors of primary myelofibrosis (PMF) patients in Shanghai and surrounding area of Shanghai, China.

Methods: The clinical manifestations, laboratory parameters and survival were retrospectively analyzed in 75 PMF patients diagnosed from Jan, 1996 to Dec, 2013 in our hospital and were compared with those of Chinese subjects from Tianjin and foreign Caucasian patients, respectively. Comparison of categorical variables was performed by χ² test.

[Influencing of chronic low back pain on multifidus muscle atrophy].

Objective: To identify the affect of chronic low back pain on multifidus muscle atrophy and fatty infiltration.

Methods: From March 2010 to August 2013, a retrospective study were carried out in the department of orthopedics of patients with low back pain. Finally 31 cases were selected to this study including 19 males and 12 females with an average age of 36.

Arsenic trioxide and bortezomib interact synergistically to induce apoptosis in chronic myelogenous leukemia cells resistant to imatinib mesylate through Bcr/Abl‑dependent mechanisms.

Arsenic trioxide (As2O3) and the proteasome inhibitor bortezomib (BTZ) have been used successfully to treat acute promyelocytic leukemia and multiple myeloma. Their synergistic effects with other anticancer drugs have been widely studied. In this study, interactions between As2O3 and BTZ were examined in imatinib‑resistant Bcr/Abl+ (K562r) cells.