The effect of the molecular weight of blackberry polysaccharides on gut microbiota modulation and hypoglycemic effect .

Blackberry polysaccharides with certain molecular weight distribution have good bioactivity. In this research, type 2 diabetes mice were used to investigate the hypoglycemic effect of blackberry polysaccharides with three different molecular weights, BBP (603.59 kDa), BBP-8 (408.

An unusual highly sensitive dual-channel bis(salamo)-like chemical probe for recognizing BO, sensing mechanism, theoretical calculations and practical applications.

A bis(salamo)-like chemical sensor HL ((1E,3E)-2-hydroxy-5-methylisophthalaldehyde O,O -di(3-((((E)-(2-hydroxynaphthalen-1-yl)methylene)amino)oxy)propyl) dioxime) was constructed. HL is capable of recognizing BO in HO/DMF (1:9, v/v) solution by both fluorescent and colorimetric channels, bright green fluorescence was turned on when BO was added to HL and changed from colorless to yellow in natural light. The detection limit was 3.

AIE/AEE tripodal PEGyl-melphalan supramolecules and detection of trinitrophenol in water.

Herein, the design of a novel aggregation-induced emission (AIE) supramolecular fluorescence sensor (TA-PEG) based on a tridentate melphalan derivative and three different molecular weight PEGs is presented. The three TA-PEG sensors could self-assemble into a supramolecular system in water and show sensitive and selective responses toward trinitrophenol.

[Comparison of effectiveness between unilateral biportal endoscopic decompression and unilateral biportal endoscopic lumbar interbody fusion for degree degenerative lumbar spondylolisthesis].

Objective: To compare the effectiveness of unilateral biportal endoscopic decompression and unilateral biportal endoscopic lumbar interbody fusion (ULIF) in the treatment of degreeⅠdegenerative lumbar spondylolisthesis (DLS).

Methods: A clinical data of 58 patients with degreeⅠDLS who met the selection criteria between October 2021 and October 2022 was retrospectively analyzed. Among them, 28 cases were treated with unilateral biportal endoscopic decompression (decompression group) and 30 cases with ULIF (ULIF group).

Combination of Chlorambucil and Mercaptopurine Show Effective Anti-Cancer Effects in Mice Model.

Background: Combination therapy employing multiple drugs has been shown to enhance the efficacy of cancer treatment. Chlorambucil (Chl) and 6-mercaptopurine (6MP) are the first-line medicines for chronic lymphocytic leukemia and ovarian cancer. However, both were limited by their short half-life of disintegration, unsatisfactory water solubility, and adverse reactions.

Synthesis of three cisplatin-conjugated asymmetric porphyrin photosensitizers for photodynamic therapy.

Photodynamic therapy provides a promising solution for treating various cancer types. In this study, three distinct asymmetric porphyrin-cisplatin complex photosensitizers (ZnPt-P1, ZnPt-P2, and ZnPt-P3) were synthesized, each having unique side chains. Through a set of experiments involving singlet oxygen detection and density functional theory, ZnPt-P1 was demonstrated to have excellent efficacy, exceeding that of ZnPt-P2 and ZnPt-P3.

Unilateral Bi/Multi-Portal Endoscopy for the Treatment of Complicated Lumbar Degenerative Diseases with Utilization of Uniaxial Spinal Endoscope, Instead of Arthroscope: Technique Note and Clinical Results.

Objective: This article aims to discuss a novel surgical strategy, referred to as unilateral bi/multi-portal endoscopy (UME), which used a uniaxial spinal endoscope instead of an arthroscope in the traditional unilateral biportal endoscopy (UBE) surgical procedure in our study of the treatment of complicated lumbar degenerative diseases.

Methods: This retrospective study included 42 patients diagnosed with high-migrated lumbar disc herniation and bilateral spinal stenosis who underwent UME surgery from January 2021 to December 2021. Patients included 20 men and 22 women, with an average age of 55.

Preparation and imaging of NIR-emissive carbonized polymer dots derived from biomass olive leaves with a quantum yield of 71.4.

The conversion of biomass materials into high value-added chemicals is receiving more and more attention. Herein, biomass olive leaves are converted into carbonized polymer dots (CPDs) through a simple hydrothermal reaction. The CPDs show near infrared light emission properties, and the absolute quantum yield reaches a record breaking value of 71.

Prediction models for the survival in patients with intestinal-type gastric adenocarcinoma: a retrospective cohort study based on the SEER database.

Objective: To explore the influencing factors of survival in intestinal-type gastric adenocarcinoma (IGA) and set up prediction model for the prediction of survival of patients diagnosed with IGA.

Design: A retrospective cohort study.

Setting And Participants: A total of 2232 patients with IGA who came from the Surveillance, Epidemiology, and End Results database.

self-exsolved ultrasmall FeP quantum dots from attapulgite nanofibers as superior cocatalysts for solar hydrogen evolution.

Developing highly active, stable, and cost-efficient cocatalysts for photocatalytic H evolution is pivotal in the area of renewable energy conversion. Herein, we present a straightforward, low-temperature phosphidation strategy for exsolving doped Fe ions from natural attapulgite (ATP) nanofibers into a supported FeP cocatalyst for the photocatalytic H evolution reaction (HER). The resulting FeP QDs/ATP features highly dispersed FeP QDs with an average size of <2 nm and a strong interfacial interaction between self-exsolved FeP QDs and the ATP substrate, thus providing ample and stable active sites for the photocatalytic HER.

Clinical efficacy and imaging outcomes of unilateral biportal endoscopy with unilateral laminotomy for bilateral decompression in the treatment of severe lumbar spinal stenosis.

Objective: To investigate the clinical efficacy and imaging outcomes of unilateral biportal endoscopy (UBE) with unilateral laminotomy for bilateral decompression (ULBD) in the treatment of severe lumbar spinal stenosis (SLSS).

Methods: We retrospectively analyzed 50 patients with SLSS treated with UBE-ULBD from October 2018 to March 2021. Visual analog scale (VAS) for back and legs pain, Oswestry disability index (ODI), modified Macnab criteria, complications, hospital stay, preoperative and postoperative dural sac cross-sectional area (DSCA) and Schizas grade, mean angle of facetectomy and osseous lateral recess decompression rate were examined.

Preparation and MRI performance of a composite contrast agent based on palygorskite pores and channels binding effect to prolong the residence time of water molecules on gadolinium ions.

Herein, gadolinium tannate was simply and conveniently coated on the surface of palygorskite by reaction of a coordination polymer formed between tannic acid and Gd. The palygorskite-tannate gadolinium-polyvinyl alcohol integrated composite (PAL@Gd@PVA) is successfully prepared after the introduction of polyvinyl alcohol onto the palygorskite-tannate gadolinium. The structure is characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction spectroscopy, X-ray photoelectron spectroscopy, and transmission electron microscopy analysis.

Diagnosis and Treatment of Cervical Spondylotic Radiculopathy Using Selective Nerve Root Block (SNRB): Where are We Now?

Cervical spondylotic radiculopathy (CSR) is one of the most common degenerative diseases of the spine that is commonly treated with surgery. The primary goal of surgery is to relieve symptoms through decompression or relieving pressure on compressed cervical nerves. Nevertheless, cutaneous pain distribution is not always predictable, making accurate diagnosis challenging and increasing the likelihood of inadequate surgical outcomes.

Tannin-Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging.

The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS.

Red Fluorescent Emissive Gd-Phenolic Nanoparticles for Fluorescence and Magnetic Resonance Bimodal Imaging.

Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd and RB of the as prepared probe are calculated to be 8.

Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress.

Parthanatos is a form of regulated cell death (RCD) that is closely linked to DNA damage, which is a common consequence of oxidative stress due to central nervous trauma, such as spinal cord injury (SCI). The mechanism by which apoptosis-inducing factor (AIF) mediates DNA strand breaks in parthanatos was not clear until the discovery of the nuclease function of MIF. A previous study suggested that observed results may not be reliable if the oxidative stress induced in cells observed under experimental pathological conditions does not accurately replicate the specific pathologies being studied.

Four rare structurally characterized hetero-pentanuclear [ZnLn] bis(salamo)-type complexes: syntheses, crystal structures and spectroscopic properties.

Four new hetero-pentanuclear 3d-4f complexes [Zn(L)La(NO)(OEt)(HO)] (1), [Zn(L)Ce(NO)(OMe)(MeOH)] (2), [Zn(L)Pr(NO)(OEt)(EtOH)] (3) and [Zn(L)Nd(NO)(OMe)(MeOH)] (4) were synthesized by the reactions of a newly synthesized octadentate bis(salamo)-based tetraoxime ligand (HL) with Zn(OAc)·2HO and Ln(NO)·6HO (Ln = La, Ce, Pr and Nd), respectively, and characterized elemental analyses, FT-IR, UV-Vis spectroscopy and single crystal X-ray crystallography. The X-ray crystallographic investigation revealed that all Zn ions were located in NO coordination spheres, and possessed a trigonal bipyramid coordination environment. The Ln ion lay in an O coordination sphere, and adopted a distorted square antiprismatic coordination environment.

Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging.

In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The value and the / ratio were about 5.6 mM s and 1.

Resveratrol alleviates lipopolysaccharide-induced inflammation in PC-12 cells and in rat model.

Background: Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we focused on PC-12 cells as an important research tool and studied the potential role of resveratrol (RSV) in inflammation induced by LPS.

Results: RSV improved inflammatory injury and functional recovery in rat model of SCI.

A simple sonochemical method for fabricating poly(methyl methacrylate)/stearic acid phase change energy storage nanocapsules.

In this study, stearic acid suitable for thermal energy storage applications was nanoencapsulated in a poly(methyl methacrylate) shell. The nanocapsules were prepared using a simple ultrasonically initiated in situ polymerization method. The morphology and particle size of the poly(methyl methacrylate)/stearic acid phase change energy storage nanocapsules (PMS-PCESNs) were analyzed using transmission electron microscopy, scanning electron microscopy, atomic force microscopy and dynamic light scattering.

2,3-Bis[(3-methyl-biphenyl-4-yl)imino]-butane.

The title compound, C30H28N2, is a product of the condensation reaction of 2-methyl-4-phenyl-aniline and butane-2,3-dione. The mol-ecule lies on a crystallographic inversion centre. The C=N bond has an E conformation.

[N,N'-Bis(2,6-diethyl-4-phenyl-phen-yl)butane-2,3-di-imine-κ(2) N,N']di-bromido-nickel(II).

The complex molecule in the title compound, [NiBr2(C36H40N2)], has mirror symmetry. The Ni(II) atom and two Br atoms are located on the mirror plane. The Ni(II) atom is four-coordinated by the two Br atoms and two N atoms from an N,N'-bis(2,6-diethyl-4-phenyl-phen-yl)butane-2,3-di-imine ligand in a distorted tetra-hedral geometry.

2,3-Bis{[2,3-dimethyl-6-(phenyl-vin-yl)phen-yl]imino}-butane.

In the title compound, C36H36N2, a product of the condensation reaction of 2,3-dimethyl-6-phenyl-vinyl-benzenamine and 2,3-butane-dione, the complete mol-ecule is generated by the application of an inversion centre. The central C-C bond in the 1,4-di-aza-butadiene fragment is trans-configured and situated about the inversion center. The dihedral angle between the ring attached to N and the 1,4-di-aza-butadiene plane is 78.