Development of a Deep Learning-Based Model for Pressure Injury Surface Assessment.

Aim: To develop a deep learning-based smart assessment model for pressure injury surface.

Design: Exploratory analysis study.

Methods: Pressure injury images from four Guangzhou hospitals were labelled and used to train a neural network model.

A New Azaphilone From the Marine Sponge-Associated Fungus Botryosporium pulchrum.

A new azaphilone, botryazaphilone (1), the first example of azaphilone featuring a 6/6/5/5 tetracyclic system, together with two known ones, chermesinone A (2) and perangustol B (3), had been obtained from the marine sponge-associated fungus Botryosporium pulchrum. The structure of 1 was elucidated through the analysis of spectroscopic data, whereas its absolute configuration was determined via single-crystal x-ray diffraction. It is the first report of the secondary metabolites isolated from the genus Botryosporium.

Caulerpin alleviates cyclophosphamide-induced ovarian toxicity by modulating macrophage-associated granulosa cell senescence during breast cancer chemotherapy.

For fertility preservation, preventing chemotherapy-induced premature ovarian insufficiency (POI) in patients with breast cancer is challenging. Our previous study suggested that caulerpin, a marine indole alkaloid, exerts antitumor effects on breast cancer cells. However, the potential effects of caulerpin on ovarian tissues remain unknown.

Galaxamide alleviates cisplatin-induced premature ovarian insufficiency via the PI3K signaling pathway in HeLa tumor-bearing mice.

Background: It is challenging to improve the effects of chemotherapy and reduce its adverse impact on the ovaries. Our previous study suggested that the combination of galaxamide could enhance the antitumor effect of cisplatin (CIS) in HeLa cell xenograft mice. However, their potential effects on ovarian tissues remain unknown.

A new 3,4-dinorsteroid from the marine sponge sp.

A new steroid, 2a-oxa-2-oxo-5-hydroxy-3,4-dinor-24-methylcholesta-22-ene (), together with 10 known ones (), was isolated from the marine sponge sp. The structures of these compounds were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compound was the third example of 3,4-dinorsteroid with a hemiketal at C-5 that was isolated from the natural source.

Electrochemically Direct Fluorination Functionalization of Styrenes with Different Fluorine Source: Access to Fluoroalkyl Derivatives.

A mild protocol for electrochemically oxidative fluorodifunctionalization of styrenes has been demonstrated. The reaction proceeds under metal, external oxidant, and catalyst free conditions, allowing tunable access to a wide variety of synthetically useful fluoroalkyl derivatives, such as β-fluorosulfone/fluoromethyl, fluorothiocyanation, and vinylsulfonyl derivatives. Moreover, CsF was shown to be the proper fluorine source for this electrochemical fluorodifunctionalization transformation.

Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest: a prospective single-center observational study.

Background: We aimed to observe the dynamic changes in glucose metabolic reprogramming-related parameters and their ability to predict neurological prognosis and all-cause mortality in cardiac arrest patients after the restoration of spontaneous circulation (ROSC).

Methods: Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Affiliated Hospital of Dalian Medical University from August 1, 2017, to May 30, 2021, were enrolled. According to 28-day survival, the patients were divided into a non-survival group (=82) and a survival group (=38).

Elements characteristics and potential environmental risk assessment of jarosite residue and arsenic sulfide residue based on geochemical and mineralogical analysis.

The waste slag known as jarosite residue (JR) and arsenic sulfide residue (ASR) were produced following the creation of zinc by hydrometallurgical procedures. The increasing annual zinc mining has led to growing pressure to dispose of the resulting JR and ASR from zinc smelting, making it crucial to assess their environmental impact and feasibility for utilization. The main components, distribution characteristics of elements, and potential environmental risks of zinc smelting wastes are studied through toxicity leaching tests, sequential extraction procedures, and various characterization technologies such as XRF, XRD, and SEM-EDS.

Marchaetoglobins A-D: Four Cytochalasans with Proangiogenic Activity from the Marine-Sponge-Associated Fungus 162105.

Four new cytochalasans, marchaetoglobins A-D (), along with five known compounds (), were isolated from the marine-sponge-associated fungus 162105. Compounds represent examples of 19,20--chaetoglobosins, of which compound is the first furan-containing cytochalasan. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism calculations.

Marcytoglobosins A and B, Cytochalasans From a Marine Sponge Associated Chaetomium globosum 162105 Fungus.

Two new cytochalasans, marcytoglobosins A (1) and B (2) were isolated from the marine sponge associated fungus Chaetomium globosum 162105, along with six known compounds (3-8). The complete structures of two new compounds were determined based on 1D/2D NMR and HR-MS spectroscopic analyses coupled with ECD calculations. All eight isolates were evaluated for their antibacterial activity.

Structural modification of natural axinelline A: Achieving reduced colitis side effects through balanced COX inhibition.

Marine natural products continue to hold great promise as potential candidates for the discovery of anti-inflammatory drug. In our previous investigation, we successfully synthesized axinelline A, a naturally occurring cyclooxygenase-2 (COX-2) inhibitor, as a promising anti-inflammatory lead compound. This study was to discover novel COX inhibitors with balanced inhibition, aiming to mitigate the severe adverse effects through further structural modification of axinelline A.

Study on the solidification performance and mechanism of heavy metals by sludge/biomass ash ceramsites, biochar and biomass ash.

Industrial by-products are stored in large quantities in the open, leading to wasted resources and environmental pollution, and the natural environment is similarly faced with phosphate depletion and serious water and soil pollution. This study uses these by-products to produce a new sludge/biomass ash ceramsite that will be used to adsorb nitrogen and phosphorus from wastewater, and solidify heavy metals in the soil while releasing Olsen P. The sludge/biomass ash ceramsites are made using sewage sludge and biomass ash in a certain ratio calcined at high temperatures and modified for the adsorption of nitrogen and phosphorus from wastewater.

Isolation and total synthesis of dysidone A: a new piperidone alkaloid from the marine sponge sp.

A new piperidone alkaloid, dysidone A (1), was isolated from the marine sponge sp. The structure of 1 was elucidated by the method of spectroscopic analysis. Compound 1 represented the first example of piperidone alkaloid isolated from the sponge of the genus with the exocyclic double bond.

(+)- and (-)-Tedanine, a pair of new enantiomeric indolone alkaloids from the marine sponge sp.

(+)- and (-)-Tedanine [(+)- and (-)-], a pair of new enantiomeric indolone alkaloids, along with nine compounds (-) were isolated from the marine sponge sp. The structures of (+)- and (-)- including absolute configurations were determined by spectroscopic analysis and quantum chemical calculation. Compounds (+)- and (-)- were the first examples of indolone alkaloids isolated from this genus.

Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway.

Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms. An in vivo rat model of I/R after AMI induction was established through the ligation of the left anterior descending (LAD) artery to assess the cardiac functions and evaluate the protective effect of protectin D1.

Two New Pairs of Enantiomeric Butenolides from the Marine Sponge Suberties sp.

Two new pairs of enantiomeric butenolides, (+)- and (-)-suberiteslide A, (+)- and (-)-subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus Suberites.

Characteristics of trace elements and potential environmental risks of the ash from agricultural straw direct combustion biomass power plant.

The rapid expansion of biomass power generation has resulted in a large amount of ash, which need to be treated urgently. The trace elements in ash also have environmental risks during treatment. Therefore, the essential characteristics and potential environmental risks of biomass ash generated by direct combustion of agricultural straw were studied.

Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β-catenin pathway in cervical cancer.

Our previous work reported that galaxamide, a cyclopeptide extracted from the seaweed Galaxaura filamentosa, showed antiproliferative activity against HeLa cells by MTT assay. In this study, the growth-inhibitory effects of galaxamide in HeLa cells and xenograft mouse models were investigated. It was found galaxamide significantly inhibited cell growth, colony formation, migration, and invasion and induced cell apoptosis by inhibiting the Wnt signaling pathway in HeLa cells.

Synthesis of ordered mesoporous silica from biomass ash and its application in CO adsorption.

It is possible to achieve high-value utilization of solid wastes and lower the cost of mesoporous silica synthesis by synthesizing mesoporous silica from solid wastes. In this study, silica was extracted using the alkali fusion method using biomass ash as the starting material. Biomass ash based mesoporous silica was successfully prepared by hydrothermal method with silicon extract solution as silicon source.

Electrochemical Difunctionalization of -Difluoroalkenes: A Metal-Free Synthesis of α-Difluoro(alkoxyl/azolated) Methylated Ethers.

A scalable electrochemical difunctionalization of -difluoroalkenes to structurally versatile difluoro motifs was achieved. This methodology features reagent-free conditions, good functional group tolerance, and a relatively broad substrate scope. Meanwhile, the electrolysis protocol is easy to handle, and the products show good regio- and chemoselectivity.