Stress responses, social support and death care experience among spouse caregivers of young and middle-aged patients with terminal cancer: a mixed-methods analysis.

Background: Faced with cancer patients in the near-death stage, spousal caregivers may experience a series of stress reactions and have a high risk of suffering from physical and psychological problems. Good social support can help alleviate stressful reactions.

Objectives: To investigate stress responses and social support among spouse caregivers of young and middle-aged patients with terminal cancer in the near-death stage, and to explore the death care experience of spouse caregivers.

Enhanced Cr(vi) removal by Co and PPy co-modified Ca-Al-layered double hydroxides due to adsorption and reduction mechanisms.

Co and polypyrrole co-modified hierarchical CaAl-LDH microspheres (CCALP) were synthesized hydrothermal and polymerization methods. The synergistic effect of PPy and Co endowed CCALP with higher surface area and more reduction sites than CaAl-LDHs modified by Co or PPy alone, maintaining good recyclability for Cr(vi) removal efficiency over four cycles without any treatment. Compared to Co, PPy doping was the dominant reason for Cr(vi) reduction on CCALP.

Prognostic impact and reasons for variability by tumor location in gastric cancer.

Background: Gastric cancer (GC) is a highly prevalent gastrointestinal tract tumor. Several trials have demonstrated that the location of GC can affect patient prognosis. However, the factors determining tumor location remain unclear.

Disruption Driving Innovation: Optimising Efficiency in Functional Neurosurgery.

Introduction: Rising NHS waiting lists are a major problem following the COVID-19 pandemic. In our institution, surgical waiting time for elective functional neurosurgical procedures, such as deep brain stimulation (DBS) and radiofrequency ablation (RFA), reached >1.5 years by the end of 2022.

Ellagic acid-based non-isocyanate polyurethane water-soluble sizing agents for enhancing the interfacial properties of carbon fiber/epoxy composites.

The preparation of environmentally friendly and efficient waterborne polyurethane sizing agents for carbon fiber (CF) is difficult, especially to avoid the use of isocyanates. Herein, ellagic acid and CO were used to prepare a five-membered cyclic carbonate compound (EARBO). The polymerization between EARBO and diamines enabled the preparation of highly efficient and green aqueous non-isocyanate polyurethane (WNIPU) sizing agents.

A novel platelets-related gene signature for predicting prognosis, immune features and drug sensitivity in gastric cancer.

Background: Platelets can dynamically regulate tumor development and progression. Nevertheless, research on the predictive value and specific roles of platelets in gastric cancer (GC) is limited. This research aims to establish a predictive platelets-related gene signature in GC with prognostic and therapeutic implications.

Brief communication: efficacy and safety of the dolutegravir/lamivudine dual therapy in antiretroviral treatment-experienced Chinese people living with HIV.

This study aimed to evaluate the efficacy and safety of dolutegravir plus lamivudine (DTG/3TC) in antiretroviral treatment (ART)-experienced people living with HIV (PLWH). A total of 303 PLWH in Shanghai, China, who switched from triple ART to DTG/3TC between January 2019 and June 2022, with a minimum ART duration of 6 months, were retrospectively enrolled. More than 95% of PLWH maintained viral suppression with no significant changes in CD4 counts 12 months after switching.

Clinical characteristics and mortality risk factors of premature infants with carbapenem-resistant Klebsiella pneumoniae bloodstream infection.

Due to the resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) to most antibiotics, CRKP treatment is challenging, which results a high mortality rate. CRKP infection poses a significant challenge for infection management and treatment, especially among neonates and premature infants. Therefore, it is important to understand the clinical characteristics of CRKP bloodstream infection (BSI) in premature infants and identify the related risk factors for death.

[Research progress on the repair of tendon injuries with Tissue Engineering Technology].

Tendon injuries are frequently encountered in clinical practice, and traditional repair methods rarely achieve complete restoration of the tendon's original structure and functionality. The challenges of accelerating and optimizing the healing of injured tendons, enhancing the strength of the regenerated tendon, and preventing adhesion remain significant in clinical settings. Tendon tissue engineering, which combines material science, cell biology, and molecular biology, involves the synergistic application of multiple factors to create functional constructs and has become an emerging technique with promise for repair.

Icariside II Preparation from Icariin Separated from Herbal Extract Powder by a Special Icariin Glycosidase.

In this study, icariside II was prepared from icariin by a special enzyme. The yield of the substrate icariin from a powdered extract of the popular herb was 16.9%.

Effects of Different Low-Intensity Pulsed Ultrasound Intensities and Durations on a Post-Traumatic Knee Joint Contracture Model in Rats.

Objective: This study aimed to investigate the low-intensity pulsed ultrasound (LIPUS) therapeutic effects on knee joint dysfunction after immobilization following trauma and to identify the optimum LIPUS intensity and duration.

Methods: A knee post-traumatic joint contracture (PTJC) model was established in male Wistar rats divided into three groups: front irradiation (n = 4), medial irradiation (n = 3), and sham (n = 3). LIPUS irradiation was performed for 20 min/day (30 mW/cm [spatial average temporal average] SATA, 1 MHz, duty cycle of 20%, 5 times/week, for 2 weeks).