, a novel cell wall-associated receptor kinase gene from , promotes growth but reduces cold tolerance in .

Cold significantly impacts the growth and development of tea plants, thereby affecting their economic value. Receptor-like kinases (RLKs) are thought to play a pivotal role in signaling the plant's response to cold and regulating cold tolerance. Among the RLK subfamilies, wall-associated receptor-like kinases (WAKs) have been investigated across various plant species and have been shown to regulate cell growth and stress responses.

Nuclear FAM289-Galectin-1 interaction controls FAM289-mediated tumor promotion in malignant glioma.

Background: FAM92A1-289(abbreviated FAM289) is recognized as one of the newly-discovered putative oncogenes. However, its role and molecular mechanisms in promoting cancer progression has not yet been elucidated. This study was performed to reveal its oncogenic functions and molecular mechanisms in human glioblastoma multiforme (GBM) cell models with knockdown or overexpression of FAM289 in vitro and in vivo.

Clarithromycin and Glipizide Drug-drug Interaction Leading to Refractory Hypoglycemia.

A 70-year-old end-stage renal disease patient was admitted for refractory hypoglycemia secondary to drug-drug interaction between clarithromycin and glipizide. We discussed the mechanism of antimicrobial and sulfonylurea interactions as well as the importance of understanding these interactions in the primary care setting to reduce medication-related hospitalizations.

Comparison of outcomes following laparoscopic and open hysterectomy with pelvic lymphadenectomy for early stage endometrial carcinoma.

Introduction: Endometrial carcinoma is the most common gynaecological malignancy. Studies have shown that laparoscopic total hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection was advantageous compared to laparotomy in reducing length of stay and intraoperative blood loss. However, these studies had a predominantly Caucasian population.

9 kilowatt-level direct-liquid-cooled Nd:YAG multi-module QCW laser.

An average 9 kilowatt-level direct-DO-cooled side-pumped Nd:YAG multi-disk laser resonator at QCW mode with a pulse width of 250μs is presented, in which the straight-through geometry is adopted the oscillating laser propagates through 40 Nd:YAG thin disks and multiple cooling DO flow layers in the Brewster angle. Much attention has been paid on the design of the gain module, including an analysis of the loss of the laser resonator and the design of the Nd:YAG thin disk. Experimentally, laser output with the highest pulse energy of more than 20 J is obtained at a repetition frequency of 10 Hz.

Association of aspartate aminotransferase in statin-induced rhabdomyolysis.

INTRODUCTION The risk of rhabdomyolysis in the general population is elevated by the increased prevalence of statin use. As the presentation of rhabdomyolysis is varied, there is a risk of delayed diagnosis leading to patient complications and increased healthcare costs. Creatine kinase (CK) alone is not sufficiently predictive for risk stratification.

Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.

4-Hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia. Inhibition of HPPD can effectively alleviate the symptoms of type I tyrosinemia. However, only one commercial HPPD inhibitor, 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione (NTBC), has been available for clinical use so far.

Identification and characterization of two novel variants of the DUF1208 protein FAM92A1.

FAM92A1 (named FAM92A1-271) belongs to the family of proteins with conserved DUF1208 domains. Its function remains elusive. We identified two novel transcript variants (FAM92A1-251, FAM92A1-289) of FAM92A1.

Isolation and characterization of a novel Xenopus gene (xVAP019) encoding a DUF1208 domain containing protein.

We have identified a novel Xenopus gene (xVAP019) encoding a DUF1208 domain containing protein. Using whole-mount in situ hybridization and RT-PCR, we found abundant xVAP019 maternal transcripts in the animal hemisphere during the cleavage stages and blastula stages. During gastrulation xVAP019 is differentially expressed with higher levels in the animal helf and the highest in marginal zone, then further expressed widely at neuronal stages with strongest signals in the prospective CNS regions and the epidermal ectoderm.