Large-scale preparation of Sb-activated hybrid metal halides with efficient tunable emission from visible to near-infrared regions for advanced photonic applications.

Zero-dimensional metal halides with diverse structures and rich photophysical properties have been reported. However, achieving multimode dynamic luminescence and efficient near-infrared (NIR) emission under blue light excitation in a single system is a great challenge. Herein, Sb-doped hybrid Cd(II) halides were synthesized by a large scale synthesis process at room temperature.

Case Report: Zero-contrast balloon pulmonary angioplasty guided by real-time fusion of CT angiography with x-ray fluoroscopy.

Background: Allergy to iodine contrast agents has long been a contraindication for balloon pulmonary angioplasty (BPA). We report the successful zero-contrast BPA procedure of a patient with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and severe iodine allergy using real-time fusion of computed tomography angiography (CTA) with x-ray fluoroscopy.

Case Presentation: A 62-year-old woman with CTEPH who developed a severe allergic reaction after the first BPA procedure.

Large measurement range curvature sensor based on all-fiber Mach-Zehnder interferometer using triple-ring-core few-mode fiber.

This study experimentally demonstrates a large measurement range curvature sensor based on a Mach-Zehnder interferometer (MZI) in a triple-ring-core fiber (TRCF). The sensor is fabricated by fusion splicing a segment of TRCF between two pieces of single-mode fiber (SMF), forming the SMF-TRCF-SMF sandwich structure. Since the TRCF can support the propagation of a few guided modes, the fundamental mode interferes with high-order modes in the sensing part to produce a periodic interference spectrum.

Contextual AI Journaling: Integrating LLM and Time Series Behavioral Sensing Technology to Promote Self-Reflection and Well-being using the MindScape App.

MindScape aims to study the benefits of integrating time series behavioral patterns (e.g., conversational engagement, sleep, location) with Large Language Models (LLMs) to create a new form of contextual AI journaling, promoting self-reflection and well-being.

Transverse mode switchable mode-locked laser with narrow bandwidth.

Transverse mode switchable ultrashort optical pulses with narrow bandwidths can create potential for exploring what we believe are new physical effects. We demonstrate the generation of transverse mode switchable ultrashort pulses with narrow bandwidths in an all-fiber mode-locked laser by exploring a mode-selective photonic lantern (MSPL). The laser cavity serves not only as a ring resonator but also as an intrinsic spectral filter.

Alleviatory Role of Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications.

COPD is an inflammatory lung disease that limits airflow and remodels the pulmonary vascular system. This study delves into the therapeutic potential and mechanistic underpinnings of Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided -related target genes, and the CTD and DisGeNET databases provided COPD-related genes.

Simultaneous realization of high gain and low DMG of four-mode EDFA under bidirectional hybrid-mode pump.

We theoretically and experimentally verify that, the bidirectional hybrid-mode pumping scheme can address the optimization problem of trade-off between high gain and low differential modal gain (DMG) of four-mode erbium-doped fiber amplifier (4M-EDFA), in comparison with traditional both forward and backward hybrid-mode pumping scheme. It is noticed that, when the total pump power is fixed, the bidirectional hybrid-mode pumping scheme can not only achieve higher gain, but also suppress DMG due to different overlap integrals for the forward and backward pumping schemes. The bidirectional hybrid-mode pumped 4M-EDFA is developed with the forward pumping at LP mode and the backward pumping at LP mode, under a pump power ratio of 30%:70%.

James Watt, of Steam Engine Fame, Offered Inhaled Carbon Monoxide for Putative Therapeutic Action.

James Watt (1736-1819) is remembered as a steam engine innovator and industrial magnate. A polymath, he was also a hands-on contributor to the Medical Pneumatic Institution of Thomas Beddoes. Watt recruited Humphry Davy, who there discovered analgesic action of inhaled nitrous oxide in 1799.

AsOBP1 is required for bioallethrin repellency in the malaria vector mosquito Anopheles sinensis.

The use of insecticides, primarily pyrethroids, is a pivotal strategy for mosquito control globally. Bioallethrin, the first commercially available volatile pyrethroid, can elicit spatial (i.e.

Non-orthogonal optical multiplexing empowered by deep learning.

Orthogonality among channels is a canonical basis for optical multiplexing featured with division multiplexing, which substantially reduce the complexity of signal post-processing in demultiplexing. However, it inevitably imposes an upper limit of capacity for multiplexing. Herein, we report on non-orthogonal optical multiplexing over a multimode fiber (MMF) leveraged by a deep neural network, termed speckle light field retrieval network (SLRnet), where it can learn the complicated mapping relation between multiple non-orthogonal input light field encoded with information and their corresponding single intensity output.

Upper Limb Cortical-Muscular Coupling Analysis Based on Time-Delayed Back Maximum Information Coefficient Model.

In musculoskeletal systems, describing accurately the coupling direction and intensity between physiological electrical signals is crucial. The maximum information coefficient (MIC) can effectively quantify the coupling strength, especially for short time series. However, it cannot identify the direction of information transmission.

Implications of left atrial volume index in patients with three-vessel coronary disease: A 6.6-year follow-up cohort study.

Background: Risk assessment and treatment stratification for three-vessel coronary disease (TVD) remain challenging. This study aimed to investigate the prognostic value of left atrial volume index (LAVI) with the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score II, and its association with the long-term prognosis after three strategies (percutaneous coronary intervention [PCI], coronary artery bypass grafting [CABG], and medical therapy [MT]) in patients with TVD.

Methods: This study was a post hoc analysis of a large, prospective cohort of patients with TVD in China, that aimed to determine the long-term outcomes after PCI, CABG, or optimal MT alone.

For patients with prior coronary artery bypass grafting and recurrent myocardial ischemia, percutaneous coronary intervention on bypass graft or native coronary artery?-A 5-year follow-up cohort study.

Background: Real-world data on target vessel of percutaneous coronary intervention (PCI) for patients with prior coronary artery bypass grafting (CABG) was still limited.

Hypothesis: A prospective cohort was examined to determine the frequency and outcomes of native coronary artery PCI versus bypass graft PCI in patients with prior CABG.

Methods: A large-sample observational study enrolled a total of 10 724 patients with coronary artery disease (CAD) underwent PCI in 2013.

Reconfigurable ultra-broadband mode converter based on a two-mode fiber with pressure-loaded phase-shifted long-period alloyed waveguide grating.

We present a reconfigurable ultra-broadband mode converter, which consists of a two-mode fiber (TMF) and pressure-loaded phase-shifted long-period alloyed waveguide grating. We design and fabricate the long-period alloyed waveguide gratings (LPAWG) with SU-8, chromium, and titanium via the photo-lithography and electric beam evaporation technique. With the help of the pressure loaded or released from the LPAWG onto the TMF, the device can realize reconfigurable mode conversion between the LP mode and the LP mode in the TMF, which is weak sensitive to the state of polarization.

Three-dimensional mode multiplexer based on adiabatic-tapered waveguides forming vertical directional couplers over C + L band and beyond.

We present a mode multiplexer based on vertical directional couplers that are formed by adiabatic-tapered waveguides. We design and fabricate the device via the micro-fabrication processing to (de)multiplex the E, E, and E modes from the few-mode bus waveguide. Our experimental device shows a coupling ratio higher than 98.

Low Power Consuming Mode Switch Based on Hybrid-Core Vertical Directional Couplers with Graphene Electrode-Embedded Polymer Waveguides.

We propose a mode switch based on hybrid-core vertical directional couplers with an embedded graphene electrode to realize the switching function with low power consumption. We designed the device with Norland Optical Adhesive (NOA) material as the guide wave cores and epoxy polymer material as cladding to achieve a thermo-optic switching for the E, E and E modes, where monolayer graphene served as electrode heaters. The device, with a length of 21 mm, had extinction ratios (ERs) of 20.

Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.

Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and oxidative damage, and oxidative stress and inflammation are considered key factors causing intervertebral disc degeneration (IVDD). Thus, restoring the mitochondrial dysfunction is an attractive strategy for treating IVDD. Platelet-derived extracellular vesicles (PEVs) are nanoparticles that target inflammation.

The Novel IGF-1R Inhibitor PB-020 Acts Synergistically with Anti-PD-1 and Mebendazole against Colorectal Cancer.

CRC is one of the leading causes of cancer mortality worldwide. Chemotherapy is widely used for the treatment of CRC, but its efficacy remains unsatisfactory, mainly due to drug resistance. Therefore, it is urgent to develop new strategies to overcome drug resistance.

Pyridine ionic liquid functionalized bimetallic MOF solid-phase extraction coupled with high performance liquid chromatography for separation/analysis sunset yellow.

An effective method based on the pyridine ionic liquid functionalized bimetallic MOF solid-phase extractant (Cu/Co-MOF@[PrPy][Br]) coupled with high performance liquid chromatography (HPLC) for the separation/analysis sunset yellow was established. Cu/Co-MOF@[PrPy][Br] was characterized by FTIR, XRD, SEM and TEM. Several important factors, such as pH, amount of extractant, extract time, and types of eluents were investigated in detail.

Intensity-interrogated hot-wire anemometer based on chirp effect of a fiber Bragg grating.

An intensity-interrogated optical fiber hot-wire anemometer based on the chirp effect of fiber Bragg grating (FBG) is presented. The FBG is coated with a silver film and heated optically by a 1480 nm laser beam, which is coupled into the fiber cladding by a long-period grating (LPG) and absorbed by the silver film to convert to thermal heat. Due to the gradual decrease of laser power along the length of the FBG, a temperature gradient is formed that induces a chirp effect to the FBG.

Efficacy and safety of PD-1 and PD-L1 inhibitors combined with chemotherapy in randomized clinical trials among triple-negative breast cancer.

The combination of immune checkpoint inhibitors (ICIs) and chemotherapy (CT) is a new strategy to explore cancer treatment in recent years, and it is also practiced in triple-negative breast cancer (TNBC). However, several published randomized controlled trials (RCTs) reported heterogeneous results. We conducted this meta-analysis to yield insights into the efficacy and safety of the combination of ICIs and CT for TNBC patients in both the adjuvant and neoadjuvant settings.

Characterizing membrane anchoring of leaf-form ferredoxin-NADP oxidoreductase in rice.

Leaf-form ferredoxin-NADP oxidoreductases (LFNRs) function in the last step of the photosynthetic electron transport chain, exist as soluble proteins in the chloroplast stroma and are weakly associated with thylakoids or tightly anchored to chloroplast membranes. Arabidopsis thaliana has two LFNRs, and the chloroplast proteins AtTROL and AtTIC62 participate in anchoring AtLFNRs to the thylakoid membrane. By contrast, the membrane anchoring mechanism of rice (Oryza sativa) LFNRs has not been elucidated.

The Use of Thromboelastography in Percutaneous Coronary Intervention and Acute Coronary Syndrome in East Asia: A Systematic Literature Review.

Dual antiplatelet therapy (DAPT), alongside percutaneous coronary intervention (PCI), is central to the prevention of ischemic events following acute coronary syndrome (ACS). However, response to therapy can vary due to several factors including CYP2C19 gene variation, which shows increased prevalence in East Asian populations. DAPT responsiveness can be assessed using techniques such as light transmission aggregometry (LTA), VerifyNow and thromboelastography with the PlateletMapping assay, and there is increasing focus on the utility of platelet function testing to guide individualized treatment.