Ammonia nitrogen affects bacterial virulence and conditional pathogenic bacterial growth by regulating biofilm microbial metabolism and EPS secretion in laboratory scale distribution systems.

The control of conditional pathogenic bacteria and inhibition of their virulence factors (VFs) in drinking water distribution systems (DWDSs) is vital for drinking water safety. This study adopted two groups of DWDSs to investigate how ammonia nitrogen affects bacterial VFs and conditional pathogenic bacterial growth in biofilms. Our results indicated that Acidimicrobium (95,916.

[Research progress of traditional Chinese medicine in treatment of benign prostatic hyperplasia].

Benign prostatic hyperplasia(BPH) is a common disease in middle-aged and elderly men, with lower urinary tract symptoms as the main manifestation, severely affecting the quality of life of patients. The pathogenesis of BPH is not yet fully understood, and there are still some challenges and limitations in western medicine treatment for BPH. Therefore, finding new and more effective treatment strategies is urgent.

Hydrous ferric arsenate transformation coupled with As, Fe, and S environmental cycling in sulfidic systems under anoxic and circumneutral conditions.

Despite many studies on the environmental cycling of As, Fe, and S, sulfide (S(-II))-induced hydrous ferric arsenate (HFA) transformation remains to be elucidated. Herein, we investigated the anaerobic reaction of HFA with S(-II) at three environmental concentrations (1, 10, and 50 mM) at pH 48. Changes in solid-phase As, Fe, and S speciation were investigated by XRD, FTIR, Raman, XPS, synchrotron XANES, SEM, and TEM.

Fabrication of a transforming growth factor β1 functionalized silk sericin hydrogel through genetical engineering to repair alveolar bone defects in rabbit.

Cleft palate is one of the most prevalent congenital craniofacial birth defects in human congenital facial anomaly. Severe cleft palate is usually accompanied by alveolar bone defects (ABDs). Growth factors (GFs) are considered as desirable opportunity to promote the craniofacial healing post the surgery.

[Effects of Storm Runoff on Bacterial Community Structure and Metabolic Activity and Water Quality in a Drinking Water Reservoir].

To explore the influence of storm runoff on bacterial metabolic activity and water quality in Jinpen Reservoir, three-dimensional fluorescence spectroscopy parallel factor analysis, high-throughput DNA sequencing technology, and Biolog technology were used to analyze variations in the components of dissolved organic matter, bacterial community composition, and microbial metabolic activity during three periods （before, during, and one month after runoff）. The results showed that after storm runoff into the reservoir, the water temperature decreased, and dissolved oxygen in the middle of the water column increased significantly. Finally, the aerobic and low-temperature state in the middle water and anaerobic and low-temperature state in the bottom water was formed.

Conductive Porous Solid Framework Mechanically Stabilized Si Anode.

Micron-sized Si anodes garner renewed attention due to their advantages of low cost, small specific surface area, and high energy density. However, micron-sized Si anodes undergo significant volume changes during lithiation/delithiation, leading to particle cracking and pulverization. This study employs the tape casting method and ultrafast high-temperature sintering technology to construct a porous sheet, within which a solid framework constrains the Si particles.

AI-Based Hematological Age Predictors and the Association Between Biological Age Acceleration and Type 2 Diabetes Mellitus - Chongqing Municipality, China, 2015-2021.

Introduction: Biological age (BA) can represent the actual state of human aging more accurately than chronological age (CA).

Methods: Using hematological data from 112,925 participants in southwestern China, collected between 2015 and 2021, this study constructed BA predictors using 7 machine learning (ML) methods (tailored separately for male and female populations). This study then analyzed the association between BA acceleration and type 2 diabetes mellitus (T2DM) within this data using logistic regression.

Predictive Value of the Systemic Immune-Inflammation Index in the 28-Day Mortality for Patients with Sepsis-Associated Acute Kidney Injury and Construction of a Prediction Model.

Purpose: The predictive value of the Systemic Immune-Inflammation Index (SII) on mortality in patients with sepsis-associated acute kidney injury (S-AKI) remains unclear. This study aims to investigate the predictive value of SII levels at the Intensive Care Unit (ICU) on the 28-day mortality of S-AKI patients.

Patients And Methods: S-AKI patients admitted to the ICU of Henan Provincial People's Hospital from January 1, 2023, to December 31, 2023.

Improving methylmalonic acidemia (MMA) screening and MMA genotype prediction using random forest classifier in two Chinese populations.

Background: Methylmalonic acidemia (MMA) is one of the most common hereditary organic acid metabolism disorders that endangers the lives and health of infants and children. Early detection and intervention before the appearance of a newborn's clinical symptoms can control disease progression and prevent or mitigate its serious consequences.

Methods: 42,004 newborns from two Chinese populations were included in the study.

Transmission Line Defect Target-Detection Method Based on GR-YOLOv8.

In view of the low levels of speed and precision associated with fault detection in transmission lines using traditional algorithms due to resource constraints, a transmission line fault target-detection method for YOLOv8 (You Only Look Once version 8) based on the Rep (Representational Pyramid) Visual Transformer and incorporating an ultra-lightweight module is proposed. First, the YOLOv8 detection network was built. In order to address the needs of feature redundancy and high levels of network computation, the Rep Visual Transformer module was introduced in the Neck part to integrate the pixel information associated with the entire image through its multi-head self-attention and enable the model to learn more global image features, thereby improving the computational speed of the model; then, a lightweight GSConv (Grouped and Separated Convolution, a combination of grouped convolution and separated convolution) convolution module was added to the Backbone and Neck to share computing resources among channels and reduce computing time and memory consumption, by which the computational cost and detection performance of the detection network were balanced, while the model remained lightweight and maintained its high precision.

Impaired neural response to reward feedback in children with high schizotypal traits: Evidences from an ERP study.

Reward processing deficit is a core feature of schizophrenia, however, it remains unclear whether reward processing is impaired in individuals with high schizotypy. In this study, 27 high schizotypal trait and 25 control group children were screened by the Chinese version of the Schizotypal Personality Questionnaire for Children (SPQC). We recorded their brain activity (event-related potentials, ERPs) while they completed a simple gambling task.

Co-selective effect of dissolved organic matter and chlorine on the bacterial community and their antibiotic resistance in biofilm of drinking water distribution pipes.

The proliferation of pathogenic bacteria and antibiotic resistance genes (ARGs) in the biofilm of drinking water distribution pipes poses a serious threat to human health. This work adopted 15 polyethylene (PE) pipes to study the co-selective effect of dissolved organic matter (DOM) and chlorine on the bacterial community and their antibiotic resistance in biofilm. The results indicated that ozone and granular activated carbon (O-GAC) filtration effectively removed lignins and proteins from DOM, and chlorine disinfection eliminated carbohydrate and unsaturated hydrocarbons, which both contributed to the inhibition of bacterial growth and biofilm formation.

Calibration of discrete meta-parameters of bamboo flour based on magnitude analysis and BP neural network.

In the research and development of technology and equipment for bamboo products deep processing, such as filling, drying, and medicinal use of bamboo flour (BF), the poor compaction and fluidity of BF materials entails the need for accurate discrete element model (DEM) and BF parameters to provide a reference for the simulation of BF processing operationsand the development of related equipment. The average particle size of the 5 types of BFs ranges from 0.136 mm to 0.

Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics.

: Circular RNA (circRNA) therapeutics hold great promise as an iteration strategy in messenger RNA (mRNA) therapeutics due to their inherent stability and durable protein translation capability. Nevertheless, the efficiency of RNA circularization remains a significant constraint, particularly in establishing large-scale manufacturing processes for producing highly purified circRNAs. Hence, it is imperative to develop a universal and more efficient RNA circularization system when considering synthetic circRNAs as therapeutic agents with prospective clinical applications.

A Subunit-Based Concept for Preoperative Design of the Cauliflower Ear.

Purpose: Cauliflower ear is an ear deformity caused by a closed ear injury with varying severity. Several studies on the systematic reconstruction of cauliflower ear have been reported. Here, the authors aim to introduce a simplified subunit-based reconstruction concept for the cauliflower ear.

Evaluation of a novel pediatric asthma inhalation drug delivery device: a focus on patient accessibility, ease of use, dosage feedback, and future directions.

Objective: Pediatric asthma management faces challenges in medication delivery through oral inhalation devices. While dry powder inhalers (DPIs) are increasingly prescribed to children, many do not receive their prescribed dosage due to insufficient inspiratory flow. This study investigates the utilization of metered-dose inhalers (MDIs) and DPIs among pediatric patients with asthma, focusing on medication delivery challenges.

Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study.

Background: Menopause significantly impacts the immune system. Postmenopausal women are more susceptible to infection. Nonetheless, the pattern of change in peripheral white blood cell counts around the menopause remains poorly understood.

Using machine learning models to identify the risk of depression in middle-aged and older adults with frequent and infrequent nicotine use: A cross-sectional study.

Background: Depression is very prevalent in middle-aged and older smokers. Therefore, we aimed to identify the risk of depression among middle-aged and older adults with frequent and infrequent nicotine use, as this is quite necessary for supporting their well-being.

Methods: This study included a total of 10,821 participants, which were derived from the China Health and Retirement Longitudinal Study Wave 5, 2020 (CHARLS-5).

Identification of NET formation and the renoprotective effect of degraded NETs in lupus nephritis.

To explore molecular biomarkers associated with the pathophysiology and therapy of lupus nephritis (LN), we conducted a joint analysis of transcriptomic data from 40 peripheral blood mononuclear cells (PBMCs) (GSE81622) and 21 kidney samples (GSE112943) from the Gene Expression Omnibus database using bioinformatics. A total of 976 and 2,427 differentially expressed genes (DEGs) were identified in PBMCs and renal tissues. Seven and two functional modules closely related to LN were identified.

Paternal Preconception Hepatitis B Virus Infection and Risk of Congenital Heart Disease in Offspring.

Importance: Previous evidence suggests that maternal hepatitis B virus (HBV) infection during prepregnancy or pregnancy is associated with congenital heart diseases (CHDs) in offspring. However, the association of paternal HBV infection with CHDs is not well examined.

Objective: To explore the association of paternal preconception HBV infection with CHDs in offspring.