Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation.

Therapeutic challenges of chronic pulmonary infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRP. aeruginosa) biofilms due to significantly enhanced antibiotic resistance. This resistance is driven by reduced outer membrane permeability, biofilm barriers, and excessive secretion of virulence factors.

Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.

Background: Delineating the shared genetic architecture of type 2 diabetes with muscle mass and function and frailty is essential for unraveling the common etiology and developing holistic therapeutic strategies for these co-existing conditions.

Methods: In this genome-wide pleiotropic association study, we performed multi-level pairwise trait pleiotropic analyses using genome-wide association study summary statistics from up to 461,026 European ancestry individuals to dissect the shared genetic factors and causal relationships of type 2 diabetes and seven glycemic traits with four muscle mass- and function-related phenotypes and the frailty index.

Results: We first identified 27 pairs with significant genetic correlations through the linkage disequilibrium score regression and high-definition likelihood analysis.

Simultaneous modulation of Ni single atoms and NiO clusters on TiO for solar-driven CO and HO conversion to CH.

Construction of the photocatalysts with synergistic active sites holds great significance in enhancing the direct CO reduction coupled with HO oxidation under solar irradiation. This work demonstrates the fabrication of a dual-active-site catalyst (Ni-NiO/TiO) through in-situ formation and simultaneous modulation of Ni single atoms (Ni) and NiO clusters on porous TiO. Both Ni and NiO are characterized by X-ray absorption fine structure (XAFS) analyses and diffuse reflectance infrared Fourier transform spectroscopy using CO as a probe molecule (CO-DRIFTS).

Unraveling key non-volatiles responsible for taste differences of Pixian broad bean paste based on sensory analysis and untargeted metabolomics.

Besides aroma, the tastes of Pixian Broad Bean Paste (PBBP) are also important, however, they have not yet been thoroughly elucidated. Therefore, this study employed sensory and untargeted metabolomics approaches to investigate taste characteristics, molecular basis and their metabolic pathways of PBBP from three different manufacturers and two grades. Results showed PBBP was predominantly characterized by strong sour, umami and salty tastes, and significant differences were observed in samples from different manufacturers and grades (p < 0.

Enhanced iodinated disinfection byproducts formation in iodide/iodate-containing water undergoing UV-chloramine sequential disinfection: Machine learning-aided identification of reaction mechanisms.

Restricted to the complex nature of dissolved organic matter (DOM) in various aquatic environments, the mechanisms of enhanced iodinated disinfection byproducts (I-DBPs) formation in water containing both I and IO (designated as I/IO in this study) during the ultraviolet (UV)-chloramine sequential disinfection process remains unclear. In this study, four machine learning (ML) models were established to predict I-DBP formation by using DOM and disinfection features as input variables. Extreme gradient boosting (XGB) algorithm outperformed the others in model development using synthetic waters and in cross-dataset generalization of surface waters.

Impact of Dietitian-Delivered Motivational Interviewing Within a Food is Medicine Intervention Targeting Adults Living With and Beyond Cancer.

Food is medicine (FIM) interventions are a strategy for preventing and managing chronic disease via diet. These interventions often combine the provision of food with access to behavior change support (e.g.

A multicenter, randomized, parallel-controlled clinical trial protocol to evaluate the safety and efficacy of irreversible electroporation compared with radiofrequency ablation for the treatment of small hepatocellular carcinoma.

Background: At present, the main clinical application of local ablation therapy, such as radiofrequency ablation (RFA), is to heat the tissue to a certain temperature. However, high temperature will cause thermal damage. Irreversible electroporation (IRE) is a novel minimally invasive local ablation technology for tumors.

Association between prenatal exposure to phthalate esters and blood pressure in children aged 3-7 years: A prospective cohort study.

Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children.

Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children.

Zinc-based radioenhancers to activate tumor radioimmunotherapy by PD-L1 and cGAS-STING pathway.

Radiotherapy and immunotherapy have already become the primary form of treatment for non-small-cell lung cancer (NSCLC), but are limited by high radiotherapy dose and low immune response rate. Herein, a multi-pronged strategy using a radio-immuno-enhancer (ZnO-Au@mSiO) is developed by inducing tumor cells apoptosis and reprograming the immunosuppressive tumor microenvironment (TME). The radio-immuno-enhancer employed Au as a radiosensitizer, transition Zn ions as immune activators, which not only tremendously enhances the anti-proliferative activity of radiotherapy toward cancer cells, but also activates the immune response with multi-targets to let "exhausted" T cells "back to life" by triggering immunogenic cell death (ICD), immune checkpoint blockade (ICB) that target PD-1/PD-L1 and cGAS-STING under X-ray irradiation with a low dosage.

[Regulatory effect of Epimedium flavonoid microparticles on pulmonary pre-metastatic microenvironment].

Tumor metastasis is the main cause of death in clinical patients. The proposal of the pre-metastatic microenvironment hypothesis offers a new research direction for tumor metastasis. Targeting and inhibiting the activation of the stimulator of interferon genes(STING) signals by tumor cell-derived microparticles may help reduce tumor metastasis.

[Exploring effects and mechanisms of Agrimoniae Herba-Coptidis Rhizoma containing serum on colorectal cancer cells via LAMP2A-mediated autophagy].

This study investigated the effects of Agrimoniae Herba-Coptidis Rhizoma(XHC-HL)-medicated serum on the proliferation, migration, invasion, and apoptosis of human colorectal cancer HT29 and HCT116 cells via the autophagy mediated by lysosome-associated membrane protein type 2A(LAMP2A). Bioinformatics analysis was conducted to explore the role of LAMP2A in the development and progression of colorectal cancer. Western blot(WB) was used to detect the expression of LAMP2A protein in colorectal cancer cell lines.

Thermo-responsive/anti-biofouling chitosan hydrogel beads in situ decorated with silver nanoparticles for water disinfection.

The development of a sustainable and eco-friendly silver-based hybrid nanocomposite for safe and efficient point-of-use (POU) water disinfection remains a challenge. Herein, a simple and facile approach was proposed for the in situ immobilization of silver nanoparticles (AgNPs) on chitosan-g-poly (sulfobetaine methacrylate) (CS-g-PSBMA) hydrogel beads, which have been achieved via graft copolymerization of sulfobetaine methacrylate along the chitosan chains followed by a drop method. The AgNPs-decorated CS-g-PSBMA hydrogel beads were characterized and their bactericidal efficacy towards Escherichia coli was evaluated concurrently with their anti-biofouling behaviors.

Continuous Evolution of Protein through T7 RNA Polymerase-Guided Base Editing in .

targeted mutagenesis technologies are the basis for the continuous directed evolution of specific proteins. Here, an efficient mutagenesis system (CgMutaT7) for continuous evolution of the targeted gene in was developed. First, cytosine deaminase and uracil-DNA glycosylase inhibitor were sequentially fused to T7 RNA polymerase using flexible linkers to build the CgMutaT7 system, which introduces mutations in targeted regions controlled by the T7 promoter.

Population expansion from central plain to northern coastal China inferred from ancient human genomes.

The population history of the northern coastal Chinese is largely unknown due to the lack of ancient human genomes from the Neolithic to historical periods. In this study, we reported 14 newly generated ancient genomes from Linzi, one of China's densely populated and economically prosperous cities from the Zhou to Han Dynasties. The ancient samples in this study were dated to the Warring States period to the Eastern Han Dynasty (∼2,000 BP).

[Best evidence summary of prevention and management of lower limb ischemia in patients with veno-arterial extracorporeal membrane oxygenation].

Objective: To provide evidence-based recommendations for the prevention and management of lower limb ischemia in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients during treatment according to search, evaluate, and summarize the best evidence on the prevention and management of lower limb ischemia in patients with VA-ECMO.

Methods: Based on the PIPOST framework (population, intervention, professional, outcome, setting, and type of evidence), an evidence-based question was formulated. A systematic search was conducted according to the "6S" evidence pyramid model in both domestic and international databases, as well as professional association websites, for all evidence related to the prevention and management of lower limb ischemia in VA-ECMO patients (aged ≥18 years).

Preoperative assessment of tertiary lymphoid structures in stage I lung adenocarcinoma using CT radiomics: a multicenter retrospective cohort study.

Objective: To develop a multimodal predictive model, Radiomics Integrated TLSs System (RAITS), based on preoperative CT radiomic features for the identification of TLSs in stage I lung adenocarcinoma patients and to evaluate its potential in prognosis stratification and guiding personalized treatment.

Methods: The most recent preoperative chest CT thin-slice scans and postoperative hematoxylin and eosin-stained pathology sections of patients diagnosed with stage I LUAD were retrospectively collected. Tumor segmentation was achieved using an automatic virtual adversarial training segmentation algorithm based on a three-dimensional U-shape convolutional neural network (3D U-Net).

New prognostic index for neoadjuvant chemotherapy outcome in patients with advanced high-grade serous ovarian cancer.

Background: A validated prognostic index for the outcome of patients with advanced high-grade serous ovarian cancer (HGSOC) undergoing neoadjuvant chemotherapy (NACT) remains elusive. To address this need, we developed an ovarian neoadjuvant chemotherapy prognostic index (ONCPI) to improve predictive accuracy.

Methods: We encompassed an analysis of the clinicopathological characteristics of patients with advanced HGSOC who were administered platinum-based NACT.

One case of Actinotignum schaalii-induced repeated infections at periumbilical scar accompanied by abscess formation and literature review.

To enhance the current clinical understanding and improve the diagnosis and treatment of Actinotignum schaalii infections, we have presented here a report of the case of recurrent infections at a periumbilical scar, induced by Actinotignum schaalii and complicated by abscess formation in a 50-year-old woman with persistent festering at the site of a periumbilical scar after laparoscopy 9 years ago, with subsequent ruptures over the past 2 years. Physical examination revealed a radial fold scar with localized redness and slight swelling of the skin below the navel. Although no significant increase in the local skin temperature was noted, tenderness was present.

Association and predictive ability between significant perioperative cardiovascular adverse events and stress glucose rise in patients undergoing non-cardiac surgery.

Background: The predictive importance of the stress hyperglycemia ratio (SHR), which is composed of admission blood glucose (ABG) and glycated hemoglobin (HbA1c), has not been fully established in noncardiac surgery. This study aims to evaluate the association and predictive capability the SHR for major perioperative adverse cardiovascular events (MACEs) in noncardiac surgery patients.

Methods: Individuals who underwent noncardiac surgical procedures between 2011 and 2020, including both diabetic and non-diabetic patients, were identified in the perioperative medicine database (INSPIRE 1.

Zinc cadmium sulphide-based photoreforming of biomass-based monosaccharides to lactic acid and efficient hydrogen production.

Approaches that add value to biomass through the use of photoreforming reactions offer great opportunities for the efficient use of renewable resources. Here, we constructed a novel zinc cadmium sulphide/molybdenum dioxide-molybdenum carbide-carbon (ZnCdS-y/MoO-MoC-C) heterojunction which was applied to photoreforming of biomass-based monosaccharides for hydrogen and lactic acid production. Bandgap engineering effectively modulated the redox capacity of ZnCdS-y and exposed more (101) crystalline surfaces, which improved the lactic acid selectivity.

Capillary Force-Assisted CsPbBrI ( = 0, 1) Columnar Crystal Film for X-ray Detectors with Ultrahigh Electric Field and Sensitivity.

Inorganic halide perovskite thin-film X-ray detectors have attracted great research interest in recent years due to their high sensitivity, low detection limit, and facile fabrication process. The poor crystal quality of the thin film with uncontrollable thickness and low background voltage during detection limits its practical application. Here, a high-quality CsPbBrI ( = 0, 1) columnar crystal film is prepared by an improved melt-confined method with a porous anodic aluminum oxide (AAO) template, which stabilizes the disorder perovskite systems of CsPbBrI by stress.