Sulfur-vacancy engineering of CoS/TiCT-MXene catalyst for efficient oxygen evolution reaction.

Integrating conductive supports and modulating electronic structures are widely recognized as effective strategies for improving the catalytic performance of transition metal sulfides. This study demonstrates the simultaneous integration of CoS with two-dimensional TiCT-MXene and the introduction of sulfur vacancies (S) in CoS through a straightforward sintering process followed by plasma treatment, culminating in the formation of the CoS/TiCT composite. Characterization results demonstrate that the TiCT support significantly improves electrical conductivity and promotes the uniform dispersion of CoS nanoparticles.

Systematic investigation and validation of peanut genetic transformation via the pollen tube injection method.

Genetic transformation is a pivotal approach in plant genetic engineering. Peanut (Arachis hypogaea L.) is an important oil and cash crop, but the stable genetic transformation of peanut is still difficult and inefficient.

A novel immune-related gene prognostic signature combining immune cell infiltration and immune checkpoint for glioblastoma patients.

Background: Glioblastoma (GBM) is a highly lethal brain tumor with a complex tumor microenvironment (TME) and poor prognosis. This study aimed to develop and validate a novel immune-related prognostic model for GBM patients to enhance personalized prognosis prediction and develop effective therapeutic strategies.

Methods: RNA sequencing and clinical data for GBM patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) (GSE83300).

A potential predictive model based on machine learning and CPD parameters in elderly patients with aplastic anemia and myelodysplastic neoplasms.

Background: Aplastic anemia (AA) and myelodysplastic neoplasms (MDS) have similar peripheral blood manifestations and are clinically characterized by reduced hematological triad. It is challenging to distinguish and diagnose these two diseases. Hence, utilizing machine learning methods, we employed and validated an algorithm that used cell population data (CPD) parameters to diagnose AA and MDS.

Peer-supported interventions for people with spinal cord injury.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the effects of peer-supported interventions on quality of life and self-management compared with control (i.e.

Meter-Scale Long Connectorized Paper-like Polymer Waveguide Film for 100 Gbps Board-Level Optical Interconnects Application.

We design and fabricate meter-scale long connectorized paper-like flexible multimode polymer waveguide film with a large bandwidth-length product (BLP) for board-level optical interconnects application. The measured BLP of the multimode waveguide is greater than 57.3 GHz·m at a wavelength of 850 nm under the strictest overfilled launch condition with a maximum length of 2.

Analysis of factors influencing the efficacy of NAC and prognosis between HER2-zero and HER2-low HR negative breast cancer.

The aim of this paper was to assess the differences in clinicopathological characteristics, efficacy and prognosis of neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor2(HER2)-zero and HER2-low hormone receptor (HR)-negative breast cancer (BC) patients, and the impact of HER2-evolution on prognosis before and after NAC. 319 triple negative breast cancer (TNBC) patients who completed NAC and surgery from August 2014 to August 2018 at Tianjin Medical University Cancer Institute and Hospital were included. Clinicopathological features, efficacy of NAC and assessment of prognosis were retrospectively analysed.

Multimodal profiling uncovers tertiary lymphoid structures as a critical determinant of immunotherapy response and prognosis in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC), historically termed 'lymphoepithelioma-like carcinoma' due to its rich lymphocyte infiltration, benefit from PD-1 blockade treatment. However, a comprehensive understanding of its tumor microenvironment (TME) remains elusive, hindering the identification of effective biomarkers for immunotherapy. We leveraged multimodal profiling data, including gene expression, immunohistochemistry, and multiplex immunohistochemistry, from three independent cohorts of NPC patients with a total of 327 patients to dissect the TME in NPC.

Combination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.

Background: Neurovascular coupling (NVC) reflects the close connection between neural activity and cerebral blood flow (CBF) responses, providing new insights to explore the neuropathological mechanisms of various diseases. Non-dialysis patients with chronic kidney disease (CKD) exhibit cognitive decline, but the underlying pathological mechanisms are unclear.

Methods: The prospective study involved 53 patients with stage 1-3a CKD (CKD1-3a), 78 patients with stage 3b-5 CKD (CKD3b-5), and 52 healthy controls (HC).

Sex-specific difference for melanoma from immunotherapy advancement.

Background: The evaluation of melanoma incidence and mortality trends based on population characteristics, with a particular focus on sex differences, is of utmost importance.

Methods: The gender-stratified analysis of melanoma mortality across various calendar years was conducted. Utilizing the Joinpoint software, we detected alterations in the incidence rates and delineated the mortality trends.

The multifunctional use of an aqueous battery for a high capacity jellyfish robot.

The batteries that power untethered underwater vehicles (UUVs) serve a single purpose: to provide energy to electronics and motors; the more energy required, the bigger the robot must be to accommodate space for more energy storage. By choosing batteries composed primarily of liquid media [e.g.

Global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across SDI levels for the global burden of disease study 2021.

Background: We aimed to assess temporal trends in type 2 diabetes mellitus (T2DM)-related deaths and disability-adjusted life years (DALYs) at global and cross-social demographic index (SDI) levels, using data from the Global Burden of Disease (GBD) in 2021.

Methods: We used geospatial mapping to visualize the global distribution of T2DM-related mortality and DALYs in 2021. Joinpoint regression assessed annual and average percent changes in DALYs and deaths from 1990 to 2021 across SDI regions.

Vertical-Structure Overcomes the Strain Limit of Stretchable Organic Electrochemical Transistors.

Intrinsically stretchable organic electrochemical transistors (IS-OECTs), utilizing organic mixed ionic-electronic conductors (OMIECs) as their channel materials, have drawn great attention recently because of their potential to enable seamless integration between bioelectronic devices and living systems. However, the fabrication of IS-OECTs presents challenges due to the limited availability of OMIEC materials that possess the desired combination of mechanical and electrical properties. In this work, 1) we report the first successful fabrication of a vertical intrinsically stretchable OECT (VIS-OECT), achieved by using elastoadhesive electrodes; 2) we experimentally proved that vertical architecture can push the strain limit of an IS-OECT from 20% to 50%; and 3) the above finding introduces an unconventional design concept: the strain limit of an IS-OECT can surpass the intrinsic stretchability of the constituent OMIECs by employing vertical structure.

Re-frying oil emulsion as buoy-bead for microalgae harvesting: A promising approach for blooms of microalgae management.

Blooms of microalgae can pose a major threat to ecological balance and human health. Therefore, a novel method of harvesting microalgae was investigated, using re-frying oil to make buoy-bead for the harvesting process. The effectiveness of the method was evaluated by water samples from the Huaihe River basin and Chaohu Lake.

Responsive plasmonic hybrid nanorods enables metabolism reprogramming via cuproptosis-photothermal combined cancer therapy.

Abnormal tumor metabolism leads to tumor growth, metastasis, and recurrence, reprogramming tumor metabolism and activating potent anti-tumor immune response have been demonstrated to have good therapeutic effects on tumor elimination. Copper-based nanomaterials involved in cuproptosis show great prospects in these two aspects, but their efficiency is restricted by Cu homeostasis and the toxicity of the chelator. Here, the pH-responsive AuNRs@CuO core-shell plasmonic hybrid nanorods (ACNRs) have been successfully fabricated to realize microenvironment-controlled release at the tumor site for the combined therapy of cuproptosis and photothermal treatment.

Scavenger receptor-A is a sensitive disease activity biomarker in ESR and CRP normal rheumatoid arthritis.

Objective: Identification of rheumatoid arthritis (RA) patients in active disease with normal ESR and CRP is a challenge in disease activity assessment. The objective of this study was to evaluate the performance and clinical significance of Scavenger receptor-A (SRA) as a disease activity biomarker in RA, especially in ESR and CRP normal patients.

Methods: One hundred and sixty-two RA (40 discovery cohort; 122 validation cohort), 20 osteoarthritis (OA), and 36 healthy controls (HCs) were recruited.