Ultra-stable and Sensitive X-ray Detectors Using 3D Hybrid Perovskitoid Single Crystals.

Organic-inorganic hybrid perovskites (OIHPs) have shown great potential for direct X-ray detection in security screening and medical diagnostics. However, their humidity stability is compromised due to the susceptibility of the structural components to water molecules, thereby limiting their practical application. In this work, stable and sensitive X-ray detection is achieved using high-quality bulk single crystals of the 3D perovskitoid (DMPZ)PbBr (DPB, DMPZ = N,N'-dimethyl-pyrazinium), wherein N-acid protons are replaced with hydrophobic alkyl groups.

Mode-informed complex-valued neural processes for matched field processing.

A complex-valued neural process method, combined with modal depth functions (MDFs) of the ocean waveguide, is proposed to reconstruct the acoustic field. Neural networks are used to describe complex Gaussian processes, modeling the distribution of the acoustic field at different depths. The network parameters are optimized through a meta-learning strategy, preventing overfitting under small sample conditions (sample size equals the number of array elements) and mitigating the slow reconstruction speed of Gaussian processes (GPs), while denoising and interpolating sparsely distributed acoustic field data, generating dense field data for virtual receiver arrays.

Age-specific abnormal glucose metabolism in HIV-positive people on antiviral therapy in China: a multicenter case-control study.

Background: Update, the link between HIV infection and abnormal glucose metabolism (AGM) is still unclear. This study aims to investigate the impact of HIV infection on AGM, including insulin resistance (IR), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Methods: A multicenter case-control study was conducted in Zhejiang province, China.

Advancements in iron-based photocatalytic degradation for antibiotics and dyes.

The accelerated growth of the economy and advancements in medical technology have led to the discharge of a diverse range of organic pollutants into water sources. Recent investigations into water treatment have demonstrated the potential for integrating photocatalysis with techniques such as photocatalytic persulfate activation and the Photo-Fenton process for more efficient wastewater management. Iron-based photocatalysts responsive to visible light offer several advantages, including non-toxicity, safety, affordability, and excellent chemical and optical properties.

Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy.

Objectives: Sepsis-associated encephalopathy (SAE) has a high incidence and mortality, especially for elderly patients and patients who are positive for pathogenic microbial infection, this study explored the prognostic factors influencing the prognosis of elderly patients with pathogenic microorganisms positive of sepsis-associated encephalopathy.

Methods: Patients with SAE and pathogenic microbiology positive were included in this study from Medical Information Mart for Intensive Care IV (MIMIC IV) database. The main results of this study was analyzed the 28-day mortality rate of patients with pathogenic microorganism positive and SAE by Wilcoxon, Kaplan-Meier curve and other methods.

Health utility scores of six common cancers in China measured by SF-6Dv2.

Purpose: Given the recent update of SF-6Dv2, detailed data on utility scores for cancer patients by cancer type remain scarce in China and other regions, which limits the precision of cost-utility analyses (CUA) in cancer interventions. The aim of the study was to systematically evaluate utility scores of six common cancers in China measured using SF-6Dv2, and identify the potential factors associated with utility scores.

Methods: A hospital-based cross-sectional survey was conducted from August 2022 to December 2023.

Association of cystatin C kidney function measures with motoric cognitive risk syndrome: evidence from two cohort studies.

Background: This study aimed to examine the associations of cystatin C, cystatin C estimated glomerular filtration rate (eGFRcys), and the difference between eGFRs (eGFRdiff) using cystatin C and creatinine levels with incident motoric cognitive risk syndrome (MCR).

Methods: We utilized data from two nationally representative cohort studies, the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015) and the US Health and Retirement Study (HRS, 2010-2018). Baseline serum cystatin C and creatinine levels were measured, and eGFRcys and creatinine estimated GFR (eGFRcr) were calculated.

Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV.

High SARS-CoV-2-specific antibody levels can protect against SARS-CoV-2 reinfection. The gut microbiome can affect a host's immune response. However, its role in the antibody response to SARS-CoV-2 in people living with HIV (PLWH) remains poorly understood.

Novel strategy to understand the bacteria-enzyme synergy action regulates the ensiling performance of wheat straw silage by multi-omics analysis.

Background: Ensiling technology shows promise for preserving and providing high-quality forage. However, the high polymeric content and compact properties of fiber result in low biodigestibility. This study aimed to evaluate the use of ensiling technology for storing wheat straw.

Stretchable Multimodal Photonic Sensor for Wearable Multiparameter Health Monitoring.

Stretchable sensors that can conformally interface with the skins for wearable and real-time monitoring of skin deformations, temperature, and sweat biomarkers offer critical insights for early disease prediction and diagnosis. Integration of multiple modalities in a single stretchable sensor to simultaneously detect these stimuli would provide a more comprehensive understanding of human physiology, which, however, has yet to be achieved. Here, this work reports, for the first time, a stretchable multimodal photonic sensor capable of simultaneously detecting and discriminating strain deformations, temperature, and sweat pH.

Chiral-Polar Alternating Cation Intercalation-Type Perovskite Enables Sensitive Self-Driven X-ray Detection with an Ultralow Detection Limit.

Metal halide perovskites (MHPs) have shown great potential for direct X-ray detection, but achieving high sensitivity without external bias remains challenging. Chiral-polar alternating cation intercalation (ACI)-type MHPs, with excellent optoelectronic properties and a robust chirality-induced bulk photovoltaic effect (BPVE), offer a promising platform for self-driven X-ray detection. Herein, impressive self-driven X-ray detection performance was achieved by utilizing chiral-polar 2D ACI-type perovskite single crystals of (-PPA)PAPbBr (; -PPA = -1-phenylpropylamine; PA = propylamine).

Silicotungstate@ZIF-67 as an effective catalyst for an extraction and oxidative desulfurization system.

Through a simple room-temperature process, different amounts of Keggin-type quaternary ammonium silicotungstate were successfully encapsulated into the metal-organic framework (MOF) material ZIF-67. The catalysts were characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and BET analysis. An extraction and catalytic oxidation desulfurization system was studied using HO as an oxidant and a deep eutectic solvent (DES) as an extractant.

Assessment of synergistic efficacy of carbaryl in combination with Cinnamomum cassia and Origanum vulgare essential oils against Dermanyssus gallinae.

The poultry red mite Dermanyssus gallinae, a prevalent ectoparasite in egg-laying poultry, severely compromises bird health and impedes the poultry industry's development. However, the escalating drug resistance due to sustained reliance on chemical acaricides highlights the urgent need for new mite management strategies. Therefore, plant essential oils (EOs), which exhibit natural acaricidal properties and environmental compatibility, represent promising candidates for developing eco-friendly acaricides.

Oxyberberine Inhibits Hepatic Gluconeogenesis via AMPK-Mediated Suppression of FoxO1 and CRTC2 Signaling Axes.

Oxyberberine (OBB), a natural metabolite of berberine, has been shown to exhibit inhibitory effects on gluconeogenesis in our previous work. This work was designed to investigate the potential effects and underlying mechanisms of OBB on hepatic gluconeogenesis. Our work found that OBB significantly inhibited the expressions of glucose 6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), and decreased the glucose production in palmitic acid-induced HepG2 cells.

RFImageNet framework for segmentation of ultrasound images with spectra-augmented radiofrequency signals.

Computer-aided segmentation of medical ultrasound images assists in medical diagnosis, promoting accuracy and reducing the burden of sonographers. However, the existing ultrasonic intelligent segmentation models are mainly based on B-mode grayscale images, which lack sufficient clarity and contrast compared to natural images. Previous research has indicated that ultrasound radiofrequency (RF) signals contain rich spectral information that could be beneficial for tissue recognition but is lost in grayscale images.

The mediating role of self-directed learning ability in the impact of educational environment, learning motivation, and emotional intelligence on metacognitive awareness in nursing students.

Purpose: This study aimed to examine the mechanisms influencing metacognitive awareness among nursing students, encompassing educational environment, learning motivation, emotional intelligence, and self-directed learning ability. These findings could be a theoretical reference for formulating metacognitive awareness intervention strategies specifically designed for nursing students.

Method: Through stratified sampling, 600 nursing students were recruited from two universities in China.

Causal association between mental disorders and cerebrovascular diseases: Evidence from Mendelian randomization study.

Background And Objective: Observational studies have suggested that mental disorders and cerebrovascular diseases (CVDs) may be risk factors for each other, but genetic evidence of a causal relationship is still lacking. We used Mendelian randomization (MR) studies to explore the causal relationship between mental disorders and CVDs from the genetic perspective.

Methods: To investigate the causal association between major depressive disorder (MDD), anxiety, attention deficit/hyperactivity disorder (ADHD), bipolar disorder and schizophrenia five kinds of mental disorders and CVDs using two-sample two-way MR analysis based on publicly available genome-wide association study (GWAS) data.

Dentatorubral-pallidoluysian atrophy: a case report and review of literature.

Background: Dentatorubral-pallidoluysian atrophy is a rare autosomal dominant neurodegenerative disease. It is a rare disease in the world. Therefore, sharing clinical encounters of this case can deepen global awareness and understanding of the disease.

NXPH4 mediated by mC contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation.

Objective: Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and therapeutic approaches for CRC, there is a need to investigate more accurate and efficient biomarkers.

Methods: Core regulatory genes were screened using the TCGA database, and the expression of neurexophilin 4 (NXPH4) and its prognostic implications were validated using tissue microarray staining.

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance.

PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Multiple resistance mechanisms have been described, including secondary mutations that restore the HR gene reading frame.

Long-term grassland diversity-productivity relationship regulated by management regimes in northern China.

Grasslands are the most extensively distributed terrestrial ecosystems on Earth, providing a range of ecosystem services that are vital for sustaining human life and critical for sustainable development at the global scale. However, the relationship between the two most important attributes of grassland, plant diversity, and productivity, remains controversial even after many years of research. Here, we develop an analysis of covariance (ANCOVA) model based on decadal-scale experimental data from a degraded meadow steppe in northeastern Inner Mongolia, China to quantify the response of aboveground biomass (AGB) to plant species diversity under varying management regimes.

High-level tumour methylation of and is required for homologous recombination deficiency in solid cancers.

In ovarian and breast cancer, promoter methylation of or is a promising biomarker for PARP inhibitor response, as high levels lead to homologous recombination deficiency (HRD). Yet the extent and role of such methylation in other cancers is not clear. This study comprehensively investigated promoter methylation of eight homologous recombination repair genes across 23 solid cancer types.

Spectral analysis enhanced net (SAE-Net) to classify breast lesions with BI-RADS category 4 or higher.

Early ultrasound screening for breast cancer reduces mortality significantly. The main evaluation criterion for breast ultrasound screening is the Breast Imaging-Reporting and Data System (BI-RADS), which categorizes breast lesions into categories 0-6 based on ultrasound grayscale images. Due to the limitations of ultrasound grayscale imaging, lesions with categories 4 and 5 necessitate additional biopsy for the confirmation of benign or malignant status.