A Respiratory Signal Monitoring Method Based on Dual-Pathway Deep Learning Networks in Image-Guided Robotic-Assisted Intervention System.

Background: Percutaneous puncture procedures, guided by image-guided robotic-assisted intervention (IGRI) systems, are susceptible to disruptions in patients' respiratory rhythm due to factors such as pain and psychological distress.

Methods: We developed an IGRI system with a coded structured light camera and a binocular camera. Our system incorporates dual-pathway deep learning networks, combining convolutional long short-term memory (ConvLSTM) and point long short-term memory (PointLSTM) modules for real-time respiratory signal monitoring.

Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling.

Liver fibrosis is a critical stage in the progression of various chronic liver diseases to cirrhosis and liver cancer. Early inhibition of liver fibrosis is crucial for the treatment of liver disease. Hepatectomy, a common treatment for liver-related diseases, promotes liver regeneration.

The Association of Red Blood Cell Transfusion with Mortality in Pediatric Patients with Sepsis, Severe Sepsis, and Septic Shock: a single-center retrospective cohort study.

Background/objectives: Pediatric patients with sepsis are frequently subjected to red blood cell (RBC) transfusions but yet its association with mortality is still controversial.

Methods: We consecutively selected 125 patients with sepsis, severe sepsis, and septic shock admitted to intensive care unit (ICU) in our center from January 2022 to January 2023, and finally 100 patients were included in this retrospective cohort study. The patients were divided into two groups: group I who received RBC transfusion and group II who did not receive RBC transfusion.

Fluorescent biosensor for ultra-stability detection of Pax-5a based on a double cascade amplification strategy.

The development of B-lymphoblastic leukemia is tightly associated with aberrant expression of Pax-5a. This work presented a novel dual signal amplification strategy-based Pax-5a detection method by combining the rolling circle amplification reaction (RCA) and the Entropy-driven toehold-mediated strand displacement (ETSD). Particularly noteworthy is the employed ETSD, which effectively improves the rate and stability of the reaction due to its unique entropy-driven principle.

A feasible approach to chromophores removal and color reduction in industrial lignin via deep eutectic solvent/isopropanol treatment.

The dark coloration of industrial lignin significantly limits its potential for applications in high-value products. This work reported a practical strategy for lignin color reduction through the synergistic treatment of acidic deep eutectic solvent and isopropanol (DES-IPA). The results showed that the DES-IPA treatment could effectively remove the p-coumarate units and methoxy groups in lignin.

Preparation of biodegradable, antibacterial core-spun yarns with braided structures using QAS/PLA micro/nanocomposites.

Medical antibacterial textiles play a vital role in tackling the issue of bacterial infection. Traditional surgical sutures face significant challenges due to wound infection caused by bacteria and breakage and scars caused by poor suture strength. Therefore, a new antibacterial and high-strength suture preparation strategy with wide clinical applicability was highly desired.

Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease.

Background: Malnutrition is prevalent in patients with inflammatory bowel disease (IBD); however, its ability to predict the disease activity in IBD remains unexplored. Therefore, this study aimed to explore the association between malnutrition and disease activity in IBD.

Methods: In this retrospective study, we enrolled 1006 patients diagnosed with IBD from the First Affiliated Hospital of Wenzhou Medical University from 2011 to 2022.

Wingless strain created using binary transgenic CRISPR/Cas9 alleviates concerns about mass rearing of Hermetia illucens.

Larvae of the black soldier fly Hermetia illucens have potential as a natural waste recycler and subsequent use as protein-rich feed for livestock. A common question about the insect-farming processes is, what about the concerns of mass escape of insects from large populations? Here, we present a binary transgenic CRISPR/Cas9 system to generate wingless strain with the potential to address this issue. We identified gonad-specific promoters in vivo and evaluated use of the two strongest promoters, nanos and exuperantia, to drive Cas9 expression.

Unveiling Active Al Sites for Ethanol Dehydration on γ-AlO with Solid-State Nuclear Magnetic Resonance Spectroscopy.

γ-AlO is a crucial catalyst widely used in industrial alcohol dehydration processes. However, the specific nature of its active sites has remained unclear. In this study, we utilize two-dimensional heteronuclear correlation solid-state nuclear magnetic resonance and density functional theory calculations to uncover the active Al sites on the surface of γ-AlO that facilitate ethanol dehydration.

Revealing nitrate sources seasonal difference between groundwater and surface water in China's largest fresh water lake (Poyang Lake): Insights from sources proportion, dynamic evolution and driving forces.

Tracing the source of nitrate is the key path to solve the problem of nitrogen pollution. However, the seasonal difference of nitrate sources in groundwater and surface water and its dynamic evolution process and mechanism in large fresh water lake area are still not clear. In this study, 126 water samples were collected from groundwater and surface water in China's largest fresh water lake (Poyang Lake) region from 2022 to 2023.

Flexible silicon for high-performance photovoltaics, photodetectors and bio-interfaced electronics.

Silicon (Si) is currently the most mature and reliable semiconductor material in the industry, playing a pivotal role in the development of modern microelectronics, renewable energy, and bio-electronic technologies. In recent years, widespread research attention has been devoted to the development of advanced flexible electronics, photovoltaics, and bio-interfaced sensors/detectors, boosting their emerging applications in distributed energy sources, healthcare, environmental monitoring, and brain-computer interfaces (BCIs). Despite the rigid and brittle nature of Si, a series of new fabrication technologies and integration strategies have been developed to enable a wide range of c-Si-based high-performance flexible photovoltaics and electronics, which were previously only achievable with intrinsically soft organic and polymer semiconductors.

Effect of Glycerol Stearates on the Thermal and Barrier Properties of Biodegradable Poly(butylene Adipate-Co-Terephthalate).

Two types of glycerol stearates, glycerol monostearate (GMS) and glycerol tristearate (GTS), were added into poly(butylene adipate-co-terephtalate) (PBAT), with the aim to improve their water vapor barrier properties. The effects of the two small molecules on microstructure, chain mobility, and surface hydrophobicity were amply assessed via both experimental and simulation methods. The incorporation of the modifiers at small loadings, 5 wt% of GMS and 1 wt% of GTS, resulted in substantial improvements in water vapor barrier properties, while a further increase in the modifier content resulted in deterioration.

Let-7c-5p Targeting CHD7 Hinders Cervical Cancer Migration and Invasion by Regulating Cell Adhesion.

Cervical cancer is one of the most common cancers worldwide. Many studies have reported the involvement of various miRNAs in cervical cancer progression. Our study was centered at investigating how let-7c-5p affected cervical cancer migration and invasion by regulating cell adhesion and its molecular mechanism.

Dual-Enhanced SERS Satellite Immuno-Nanocomplex for Multiple PSA-Mediated PHI Assay Toward Clinical Prostate Cancer Screening.

Prostate specific antigen (PSA) is widely used in liquid biopsy of prostate cancer (PCa) but still faces challenges due to the poor specificity. Herein, this study reports a double-SERS satellite immunoassay, made of an Au-Ag dealloyed intra-nanogap nanoflower (Au-Ag DINF) with strong SERS signals and Au magnetic nanoparticles (AuMNPs) with magnetic capture and SERS amplification, for sensing multiple PSA (free PSA (fPSA), complexed PSA (cPSA) and [-2]proPSA (p2PSA)) toward potential PCa screening. Unlike the previous studies focus on the tPSA and fPSA/tPSA ratio (f/t PSA%), this work introduces a multiple PSA-mediated Prostate Health Index (PHI) assay with significantly increased the predictive accuracy and specificity of PCa, especially the patients with a tPSA level in the "diagnostic gray zone".

Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity.

Introduction: Ginseng demonstrates therapeutic potential in treating obesity, with both experimental and clinical studies suggesting its anti-obesity effects are mediated by gut microbiota. Nonetheless, the specific chemical components responsible for this effect remain largely unidentified.

Objectives: This study aims to investigate the anti-obesity effects and mechanisms of ginseng polysaccharides (GP) and ginsenosides (GS), the primary chemical components of ginseng, with a focus on their impact on gut microbiota.

Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).

Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

Strengthened d-p Orbital Hybridization on Metastable Cubic MoC for Highly Stable Lithium-Sulfur Batteries.

Suppressing the lithium polysulfide (LiPS) shuttling as well as accelerating the conversion kinetics is extremely crucial yet challenging in designing sulfur hosts for lithium-sulfur (Li-S) batteries. Phase engineering of nanomaterials is an intriguing approach for tuning the electronic structure toward regulating phase-dependent physicochemical properties. In this study, a metastable phase δ-MoC catalyst was elaborately synthesized via a boron doping strategy, which exhibited a phase transfer from hexagonal to cubic structure.

Novel benzothiazole derivatives target the Gac/Rsm two-component system as antibacterial synergists against infections.

The management of antibiotic-resistant, bacterial biofilm infections in skin wounds poses an increasingly challenging clinical scenario. infection is difficult to eradicate because of biofilm formation and antibiotic resistance. In this study, we identified a new benzothiazole derivative compound, (IC = 43.

Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4.

Alcoholic steatohepatitis (ASH) is a liver disease characterized by steatosis, inflammation, and necrosis of the liver tissue as a result of excessive alcohol consumption. Pregnane X receptor (PXR) is a xenobiotic nuclear receptor best known for its function in the transcriptional regulation of drug metabolism and disposition. Clinical reports suggested that the antibiotic rifampicin, a potent human PXR activator, is a contraindication in alcoholics, but the mechanism was unclear.

Intraventricular medication with or without ventricular shunt for leptomeningeal metastases with different intracranial pressure: A single-center, large-scale retrospective study.

Objectives: To evaluate the efficacy and prognosis of intraventricular medication administered via the reservoir of Ommaya or ventricular shunt system to control leptomeningeal metastases, with or without ventricular shunt based on intracranial pressure, in combination with postoperative systemic therapy.

Methods: Between April 2021 and December 2022, 125 patients with leptomeningeal metastases were managed in our department who underwent Ommaya reservoir placement and/or ventricular shunt and subsequently received intraventricular medication postoperatively. The extent of symptom amelioration and survival, as well as the determinants influencing prognosis, were evaluated.

AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis.

AdipoRon has been validated for its ability to reverse liver fibrosis, yet the underlying mechanisms remain to be thoroughly investigated. Collagen, predominantly synthesized and secreted in hepatic stellate cells (HSCs), relies on glycine as a crucial constituent. Activating transcription factor 4 (ATF4) serves as a pivotal transcriptional regulator in amino acid metabolism.

Reviving Zn Dendrites to Electroactive Zn by Ion Sieve Interface.

Zn dendrite formation during repeated plating/stripping processes limits the practical use of Zn-metal anodes in reliable and affordable energy storage. Traditional methods, including dendrite suppression and dendrite regulation, fail under demanding performance conditions due to Zn diffusion limitations and concentration gradients. Here, using an in situ pre-zincation approach, a LiZnTiO (LZTO, 0 View Article and Find Full Text PDF

Evidence of Preferential Aluminum Site Loss during Reaction-Induced Dealumination.

Understanding the mechanism of steam-induced dealumination of zeolite catalysts is of high relevance for tuning their performance and stability in multiple industrial processes. A combination of Al and H-H double-quantum single-quantum magic angle spinning nuclear magnetic resonance and diffuse-reflectance ultraviolet-visible spectroscopies identified a preferential dealumination of tetrahedral aluminum sites in H-ZSM-5 zeolites. Framework aluminum atoms facing channels display reactivity toward steam higher than that of those in their intersections.

Association Between Time to Treatment and Outcomes of Endovascular Therapy vs Medical Management in Patients With Large Ischemic Stroke.

Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.

Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.