Advanced aqueous phenazine redox flow battery enhanced by selective interfacial water behavior on Co/NC modified electrode.

Although aqueous organic redox flow battery (RFBs) is a highly promising energy storage device, the redox reaction kinetics of the anode organic electrolyte material, especially for phenazine derivatives, are limited by low electrochemical activity of traditional porous carbon electrodes. Herein, Co/NC composite electrocatalyst was elaborated to significantly enhance the redox reaction kinetics of phenazine derivatives, in which Co/NC electrocatalyst could improve energy efficiency of aqueous phenazine RFBs by 43.2 % compared to pure carbon felt electrodes at current density of 100 mA/cm.

Pan-cancer analysis reveals age-associated genetic alterations in protein domains.

Cancer incidence and mortality differ among individuals of different ages, but the functional consequences of genetic alterations remain largely unknown. We systematically characterized genetic alterations within protein domains stratified by affected individual's age and showed that the mutational effects on domains varied with age. We further identified potential age-associated driver genes with hotspots across 33 cancers.

USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer.

Background: Radiotherapy is a major modality for esophageal cancer (ESCA) treatment, yet radioresistance severely hampers its therapeutic efficacy. Ubiquitin-specific peptidase 14 (USP14) is a novel deubiquitinase and can mediate cancer cells' response to irradiation, although the underlying mechanism remains unclear, including in ESCA.

Methods: To evaluate the expression of USP14 in ESCA tissues or cells, we used RNA-Seq, immunoblotting, co-immunoprecipitation (Co-IP), ubiquitination, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence assays in this investigation.

Volatile content and genetic variation of citron in Tibet and Yunnan.

Citron (Citrus medica) is a representative aromatic species of the Citrus genus in the Rutaceae family. To determine the volatile profiles and genetic variation of citron, we collected 218 citron accessions within China, including 130 from Yunnan and 88 from Tibet. We identified a total of 80 volatile compounds from their pericarps.

MnCoO spinel activates peroxymonosulfate for highly effective bisphenol A degradation with ultralow catalyst and persulfate usage.

Persulfates-based advanced oxidation processes are highly efficient in degrading refractory organic contaminants in wastewater. However, their practical application is often limited by the extensive consumption of catalysts and oxidants. Therefore, constructing catalysts with abundant and efficient reaction interfaces is essential for improving the efficiency of persulfate activation.

Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review.

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis. The presence of epigenetic abnormalities, immune dysregulation, hyperinflammation and active angiogenesis in AITL offers potential targets for histone deacetylase (HDAC) inhibitors and immunomodulatory drugs (IMiDs).

Tyrosine kinase 2 inhibitors: Synthesis and applications in the treatment of autoimmune diseases.

Janus kinase (JAK), a class of non-receptor tyrosine kinases, are essential in modulating the cytokine signaling cascade of cytokines associated with immune responses. Despite their potential in the treatment of autoimmune diseases, JAK inhibitors are associated with safety concerns, regarding cytokine suppression and significant side effects. Tyrosine kinase 2 (TYK2), a prominent member of the JAK family, is central to the signaling of interleukins (ILs) and interferons (IFNs), such as IL-12, IL-23 and IFNs.

Population-based active surveillance of pertussis hospitalization rates in two cities of China.

Purpose: Hospitalization is most common for severe pertussis cases and those with serious complications caused by pertussis. In mainland China, the immunization program consists of primary vaccinations at 3, 4, and 5 months, followed by a booster at 18 months with DTaP. It remains uncertain whether the first dose at 3 months, rather than 6 weeks as WHO recommended, may increase disease burden, as delayed immunization may lead to lagged protection.

Chronic hypoxia promotes pulmonary venous smooth muscle cell proliferation through the CaSR-TRPC6/ROCE pathway.

The mechanism underlying chronic hypoxia (CH)-induced pulmonary venous remodeling remains unclear. Cell proliferation is key in vascular remodeling, and the calcium-sensing receptor (CaSR) protein contributes to CH-induced pulmonary venous smooth muscle cell (PVSMC) proliferation. In pulmonary arterial smooth muscle cells, CaSR and transient receptor potential canonical (TRPC) proteins interact, contributing to CH-induced cell proliferation via CaSR-TRPC1/6 signaling.

Prevalence of serotypes causing pneumococcal diseases in the Chinese Mainland: A systematic review and meta-analysis.

Pneumococcal disease (PD) caused by () continues to be a global public health concern. Monitoring the prevalence and shift of serotypes causing PD is critical for vaccination and local policies for PD management. A systematic review of published work on pneumococcal serotype distribution in the Chinese Mainland from January 1997 to July 2023 was conducted.

KIF20A activated by transcription factor GATA2 promotes cell growth in hepatitis B virus-related hepatocellular carcinoma.

Background: Elevated evidence suggests that KIF20A plays an important role in hepatocellular carcinoma (HCC) progression. Nevertheless, the underlying mechanism by which KIF20A promotes HCC cell growth are not well understood.

Methods: Using TCGA-LIHC RNAseq and GEO datasets, we assessed the KIF20A expression and patient survival in HCC and hepatitis B virus (HBV)-related HCC.

FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein.

Porcine deltacoronavirus (PDCoV), a newly discovered intestinal coronavirus, has rapidly spread among pigs worldwide and has shown the potential for cross-species infection. However, the interaction mechanism between PDCoV and the host's antiviral response is still poorly understood. In this study, an E3 ubiquitin ligase FBXW8 was explored on PDCoV proliferation.

CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases.

Increasing scRNA-seq data in cardiovascular research have substantially improved our knowledge on the development of the cardiovascular system and the mechanisms underlying cardiovascular diseases. However, the single-cell transcriptome datasets were dispersed in literature and no resource for cardiovascular systems and diseases. Here, we constructed an organized resource CardioAtlas, which provides comprehensive analysis results for > 1,929,000 cells in 27 human data sets and > 1,088,000 cells in 39 mouse data sets.

Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China.

Background: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system.

Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang province of China. Patients with suspected pertussis were further confirmed as pertussis cases by PCR and culture.

Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations.

Small molecules that possess the ability to regulate the interactions between Son of Sevenless 1 (SOS1) and Kristen rat sarcoma (KRAS) offer immense potential in the realm of cancer therapy. In this study, we present a novel series of SOS1 inhibitors featuring a tricyclic quinazoline scaffold. Notably, we have identified compound 8d, which demonstrates the highest potency with an IC value of 5.

Identifying and quantifying multiple pollution sources in estuaries using fluorescence spectra and gradient-based deep learning.

This study developed an intelligent method for identifying and quantifying water pollution sources in estuarine areas. It characterized the excitation-emission matrix (EEM) fluorescence spectra from seven end-members, including seawater, rainwater, and five pollution sources typical of these areas. A deep learning model was established to identify and quantify these pollution sources in mixed water bodies.

Preliminary study on the potential impact of probiotic combination therapy on infection in children using 16S gene sequencing and untargeted metabolomics approach.

Objective: The purpose of this study was to explore the potential mechanism of (Hp) eradication by probiotic therapy through 16S rRNA gene sequencing technology and untargeted metabolomics.

Methods: Twenty four Hp-infected children were recruited from the Shanxi Bethune Hospital, and 24 healthy children were recruited as a blank control group. Group A: fecal samples from 24 healthy children.