Pinpointing the integration of artificial intelligence in liver cancer immune microenvironment.

Liver cancer remains one of the most formidable challenges in modern medicine, characterized by its high incidence and mortality rate. Emerging evidence underscores the critical roles of the immune microenvironment in tumor initiation, development, prognosis, and therapeutic responsiveness. However, the composition of the immune microenvironment of liver cancer (LC-IME) and its association with clinicopathological significance remain unelucidated.

Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice.

Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs. However, its relationship with cholesterol metabolism remains unclear.

Hydrogen storage properties of TiFe-based composite with Ni addition.

This paper presents the preparation of the parental experimental alloy, featuring a standard composition of TiYZrFeNiMn, via the vacuum induction melting technique. Subsequently, the TiYZrFeNiMn alloy, with an addition of 2 wt% Ni, underwent mechanical ball milling to yield a TiFe-based composite for experimental purposes. The results of the experimental tests indicate that the composite alloy's phase composition comprises the TiFe primary phase, with a minor quantity of ZrMn phase segregated on the surface of the primary TiFe phase, as well as Ni phase.

Identification of genetic loci and candidate genes regulating photosynthesis and leaf morphology through genome-wide association study in L.

Rapeseed ( L.) is a major agricultural crop with diverse applications, particularly in the production of seed oil for both culinary use and biodiesel. However, its photosynthetic efficiency, a pivotal determinant of yield, remains relatively low compared with other C plants such as rice and soybean, highlighting the necessity of identifying the genetic loci and genes regulating photosynthesis in rapeseed.

Salivary exosomes exacerbate colitis by bridging the oral cavity and intestine.

Inflammatory bowel disease (IBD) presents a range of extraintestinal manifestations, notably including oral cavity involvement. The mechanisms underlying oral-gut crosstalk in IBD are not fully understood. Exosomes, found in various body fluids such as saliva, play an unclear role in IBD that requires further exploration.

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

Physiological Insights Into the Role of Pericytes in Spinal Cord Injury.

Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair.

RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters.

Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of esophageal cancer cases. The lack of effective therapeutic targets makes it difficult to improve the overall survival of patients with ESCC. Reticulon 4 Interacting Protein 1 (RTN4IP1) is a novel mitochondrial oxidoreductase.

Lightweight Lung-nodule Detection Model Combined with Multidimensional Attention Convolution.

Background: Early and timely detection of pulmonary nodules and initiation treatment can substantially improve the survival rate of lung carcinoma. However, current detection methods based on convolutional neural networks (CNNs) cannot easily detect pulmonary nodules owing to low detection accuracy and the difficulty in detecting small-sized pulmonary nodules; meanwhile, more accurate CNN-based models are slow and require high hardware specifications.

Objective: The aim of this study is to develop a detection model that achieves both high accuracy and real-time performance, ensuring effective and timely results.

RiceSNP-ABST: a deep learning approach to identify abiotic stress-associated single nucleotide polymorphisms in rice.

Given the adverse effects faced by rice due to abiotic stresses, the precise and rapid identification of single nucleotide polymorphisms (SNPs) associated with abiotic stress traits (ABST-SNPs) in rice is crucial for developing resistant rice varieties. The scarcity of high-quality data related to abiotic stress in rice has hindered the development of computational models and constrained research efforts aimed at rice improvement and breeding. Genome-wide association studies provide a better statistical power to consider ABST-SNPs in rice.

Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis.

Background: Breast cancer (BC) is the most prevalent solid cancer affecting women's health globally. Matrine (MAT), a traditional Chinese herb, has exhibited antitumor effects against BC. However, its mechanism of action, particularly whether it involves the control of cell proliferation and epithelial-mesenchymal transition (EMT), remains unknown.

Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses.

Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) in the glycolysis branching pathway is specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S-D-lactoylglutathione (SLG) accumulates in the cytosol and directly induces D-lactyllysine modification of proteins.

Soy protein isolate/dextran glycation conjugates: Fabrication through ultrasound-assisted cyclic continuous reaction and their applications as carriers of anthocyanins.

The precise control of browning and enhancement of Maillard reaction kinetics to improve the surface functionality and nutrient encapsulation efficiency of soy proteins remains a significant challenge. This research presents an ultrasound-assisted cyclic reaction method (1-7 cycles) to synthesize soy protein isolate/dextran (SPI/D) conjugates with enhanced grafting degree and functionality during the Maillard reaction. The technique significantly increased the grafting degree to 65.

Preparation of porous carbon derived from a lignin-based polymer through ZnCl activation for effective capture of iodine.

Lignin-based porous carbon, a derivative of lignin, is acknowledged for its cost-effectiveness, stability, and environmental sustainability. It exhibits significant adsorption capacity for the removal of heavy metals and in wastewater treatment, rendering it a highly esteemed adsorbent material. However, the potential of lignin-derived porous carbon for the capture of iodine in environmental contexts has yet to be thoroughly investigated.

Engineering an Mn(II)-oxidizing Pseudomonas whole-cell catalyst chassis to efficiently biosynthesize 2,5-furandicarboxylic acid from hydroxymethylfurfural.

2,5-Furandicarboxylic acid (FDCA) is a high-value chemical extensively used in the production of bio-based polymers, but bioconversion of furan derivatives like 5-hydroxymethylfurfural (HMF) into FDCA remains challenging owing to substrate cytotoxicity. Here, we engineered an Mn(II)-oxidizing Pseudomonas sp. MB04B for efficient FDCA biosynthesis from HMF.

Effect of Tanreqing injection on multidrug resistance organisms: A test-negative case-control study and network pharmacology analysis.

Background: Multidrug resistance organisms (MDROs) pose a major threat in intensive care units (ICUs). Although in vitro studies suggested that Tanreqing (TRQ) was effective against MDROs, evidence about TRQ injection usage and its real-world effectiveness is lacking.

Purpose: This study aimed to investigate treatment pattern and real-world effectiveness of TRQ against MDRO infections among ICU patients being treated with antibiotics.

The role of di-(2-ethylhexyl) phthalate in cancer initiation and progression: Mechanisms and health implications.

The increasing prevalence of cancer has been linked to various environmental factors associated with modern industrial and societal advancements. Di-(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer, is one such environmental contaminant with potential carcinogenic effects. While epidemiological studies have suggested a positive association between DEHP exposure and cancer risk, the specific role of DEHP in cancer initiation and progression requires further clarification.

Mechanistic study of the calcination process in magnesium production: Application of the Darcy-Clausius coupling model for improving environmental efficiency.

In the process of industrialization, it is found that the calcination process is an important factor affecting the reduction rate, which determines the energy consumption and carbon emission of the reaction process. In this study, the micro-nano physical model of the factors affecting the reduction rate of calcined precursors was constructed by coloring the SEM results of pellets before and after calcination with Gaussian height expression and combining Clausius and Gibbs equations. The influence of the formation degree of the internal pores of the pellets on the reduction rate was analyzed by controlling the calcination time of the precursor.

Acquisition and transcriptomic analysis of tissue micro-regions using a capillary-based method.

Profiling the site-specific transcriptomes of microregions of interest (mROIs) contributes to a complete understanding of multicellular organisms. However, the simple and efficient isolation of mROIs for spatially detecting gene expression remains challenging. Here, we develop an efficient capillary-based microdissection system (CMS) for precisely isolating targeted samples from tissue sections.

Carboxyl and carbonyl groups of carbon dots co-coordinated assembly with Al to emission-enhanced aggregates for sensitive sensing and efficient removal.

It is very challenging to prepare carbon dots (CDs) with aggregation-induced emission (AIE) property for simultaneous sensitive sensing and efficient removal. Herein, blue-emission CDs were facilely prepared by one-step solvothermal treatment of vine tea. Optical characterizations demonstrated that AIE phenomenon of CDs came from the restricted intramolecular motion.

Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response.

Purpose: Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).

Methods: Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included.

Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages.

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time.

Biodegradable copper-containing mesoporous microspheres loaded with ginsenoside Rb1 for infarcted heart repair.

The current unavailability of efficient myocardial repair therapies constitutes a significant bottleneck in the clinical management of myocardial infarction (MI). Ginsenoside Rb1 (GRb1) has emerged as a compound with potential benefits in safeguarding myocardial cells and facilitating the regeneration of myocardial tissue. However, its efficacy in treating MI-related ischemic conditions is hampered by its low bioavailability and inadequate angiogenic properties.