Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis.

Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hindered by the short half-life and limited diffusion distance of active molecules. Herein, we report a three-arm structure using the photosensitive core chlorin e6 to integrate three α-cyclodextrin (α-CD) polyrotaxane chains as the supramolecular nanocarrier of NO-enhanced PDT therapy, in which NO was loaded on the cationic rings (α-CDs).

Platelet Activation-Induced In Situ Trapping Metastatic Tumor Cells Strategy for Post-Surgery Tumor Recurrence Immunochemotherapy.

The reasons for the high recurrence and metastasis after triple-negative breast cancer (TNBC) surgery are the potential presence of micrometastases and disseminated tumor cells in the circulation, as well as the immunosuppressive microenvironment caused by the surgery. To address these issues, this work proposed a platelets (PLTs) based hydrogel delivery system for immuno-chemotherapy, (IL-12+NP-PLT)@dAlg. To utilize the targeting ability of PLTs toward tumor cells and maintain the activity of PLTs, doxorubicin-loaded nanoparticles (NP) were attached on the surface of PTLs (NP-PLT).

Broadband all-dielectric meta-lenses with terahertz full-Stokes polarization detection behavior.

Polarization is a fundamental characteristic of electromagnetic (EM) waves, and accurately determining the polarization state is crucial for spectral imaging and information processing. However, implementing broadband polarization detection in the terahertz (THz) range poses significant challenges when employing conventional optics. This paper proposes and experimentally evaluates a broadband polarization detection strategy using all-dielectric metasurfaces.

Large-mode-area Nd-doped anti-resonant phosphate fiber for high-power single-mode 900 nm laser generation.

In this work, we propose an Nd-doped double-layer anti-resonant phosphate fiber with a core diameter of 50 µm for high-power single-mode 900 nm laser generation. Double-layer interlaced anti-resonant elements were designed here to enhance the fundamental mode confinement capability of the large-mode-area Nd-doped fiber core. Moreover, a double-layer F-P etalon formed between the anti-resonant elements and the inner cladding was analyzed for the first time for fiber loss manipulation.

Toward an advanced physics-based scheme for retrieving land surface emissivity and temperature based on Fengyun-3D MERSI-II daytime mid-infrared data.

The hybrid nature of the mid-infrared (MIR) spectrum complicates the separation of reflected solar irradiance from total energy. Consequently, existing studies rarely use MIR satellite data alone for retrieving land surface temperature (LST) and land surface emissivity (LSE). In this study, we developed What we believe to be a novel physics-based approach to retrieve LSE and LST using MIR channel data from the MEdium Resolution Spectral Imager II (MERSI-II) onboard China's new-generation polar-orbiting meteorological satellite Fengyun-3D (FY-3D).

Dual-biomimetic curved compound-eye camera system for multi-target distance measurement in a large field of view.

Biomimetic curved compound-eye cameras (BCCECs) have attracted great attention for their potential applications in a variety of fields such as target recognition, monitor and three-dimensional localization in military due to their unique optical properties such as large field of view (FOV) and small size. In this work, we proposed a multi-target distance measurement method based on a dual-BCCEC system in a large FOV. To guarantee the precise measurement of the distance of multiple targets, a feature point searching and matching algorithm is developed for the dual-BCCEC system to improve the localizing efficiency of common feature points.

Federated learning-based wavelength demodulation system for multi-point distributed multi-peak FBG sensors.

Machine learning-based demodulation of multi-peak fiber Bragg grating (FBG) sensors has been extensively studied, demonstrating superior performance compared to conventional algorithms because it can neglect potential physical constraints. As the number of real-world monitoring points increases, the volume of fiber-optic sensing data grows exponentially. This necessitates aggregating data from various regions (e.

Towards perceptual uniformity and HDR-WCG image processing: a projection-based color space.

High dynamic range (HDR) and wide color gamut (WCG) images are now commonly available, challenging the property of the existing color spaces, which play an important role in color image processing and color vision applications. In this study, a perceptually uniform color space is proposed for HDR and WCG image processing. The basic structure of this color space is reconstructed by two 3D projection transformation matrices and a modified nonlinear function.

Design of tunable selective light-absorbing metasurfaces driven by intrinsically chiral quasi-bound states in the continuum.

Chiral metasurfaces with high quality factors (Q-factors) and strong circular dichroism (CD) are excellent platforms for studying chiral optical response. Here, a design is proposed of an intrinsic chiral silicon metasurface driven by bound states in the continuum (BIC), with ultra-high Q-factor (Q = 3722) and chirality response close to the unit CD (CD > 0.99).

Design and experimental research of orbital angular momentum multiplexing holography based on optical diffraction neural network.

The orbital angular momentum (OAM) multiplexing holography has the advantages of large information capacity and high security, and has important application value in holographic storage, optical encryption, and optical computing. However, as the number of multiplexing channels increases, this technology suffers from deterioration in image quality, which limits its application scope. This article proposes an innovative design that introduces an optical diffractive neural network (ODNN) into OAM multiplexing holography, establishes a scientific image quality evaluation function, applies an end-to-end optimization method, and designs OAM multiplexing holograms in parallel, significantly improving the image quality of OAM holography.

Influences of Community Coalescence on the Assembly of Bacterial Communities of the Small-Scale Complex Aquatic System from the Perspective of Bacterial Transmission, Core Taxa, and Co-occurrence Patterns.

Recirculating aquaculture and aquaponics are considered sustainable aquaculture models playing important roles in animal-derived protein supply. In these aquaculture systems, microorganisms are crucial for the system stability. The community coalescence by mixing substances and microorganisms from various microhabitats under hydraulic forces is important for shaping the bacterial communities in these small-scale complex systems.

Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation.

2'-O-methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only known small nucleolar ribonucleoprotein (snoRNP) 2'-O-methyltransferase.

Correction: A multifunctional black phosphorus nanosheet-based immunomagnetic bio-interface for heterogeneous circulating tumor cell capture and simultaneous self-identification in gastric cancer patients.

Correction for 'A multifunctional black phosphorus nanosheet-based immunomagnetic bio-interface for heterogeneous circulating tumor cell capture and simultaneous self-identification in gastric cancer patients' by Yifan Zuo , , 2023, , 3872-3883, https://doi.org/10.1039/D2NR04277K.

Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration.

Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA modification-dependent translational regulation in these processes remains largely unknown. Planarians, renowned for their ability to undergo remarkable tissue regeneration, provide an ideal model for the analysis of differential rRNA regulation in diverse cell types during tissue homeostasis and regeneration.

Pre- and post-polyphenol intake and ovarian cancer survival: evidence from a prospective cohort study.

Purpose: Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.

Methods: The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival.