Protocol of an adaptive mobile health intervention for the management of gestational weight gain: The LEAP cluster randomized controlled trial.

Background: More than half of pregnant patients with overweight or obesity exceed national gestational weight gain (GWG) guidelines, increasing their risk of adverse outcomes. There is an urgent need to develop effective and scalable interventions to improve GWG.

Objective: To describe the protocol of Lifestyle, Eating, and Activity in Pregnancy (LEAP), a cluster randomized controlled trial evaluating a mobile health (mHealth) intervention promoting appropriate GWG in an integrated healthcare system.

Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell.

Background: Diabetes mellitus (DM) can cause severe complications, including diabetic foot ulcers (DFU). There is a significant gap in understanding the single-cell ecological atlas of DM and DFU tissues.

Methods: Single-cell RNA sequencing data were used to create a detailed single-cell ecological landscape of DM and DFU.

A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment of infections.

Schistosomiasis is commonly managed using the praziquantel, but it is only effective against adult worms and duration of action is short. Liver fibrosis will worsen if eggs are still present after stopping treatment. Therefore, this study aimed to develop a sustained drug release system for effectively preventing and treating schistosomiasis.

The Growing Altitude Influences the Flavor Precursors, Sensory Characteristics and Cupping Quality of the Pu'er Coffee Bean.

The growing altitude is an important factor affecting the quality of coffee. We explored the flavor precursors, sensory characteristics, and cupping qualities of coffee growing at different altitudes and discussed their associated relationships. The altitude at which coffee is grown has different effects on its chemical composition.

The development of kind concepts: Insights from object individuation.

Object individuation studies have been a valuable tool in understanding the development of kind concepts. In this article, we review evidence from object individuation paradigms to argue that by their first birthday, infants represent at least three superordinate-level sortal kinds: OBJECT, ANIMATE, and AGENT (possibly also ARTIFACT). These superordinate sortal-kind concepts share key characteristics of adult kind concepts, such as prioritizing causal properties and having inductive potential.

Alginate catabolic systems in marine bacteria.

Brown algae, constituting the second largest group of marine macroalgae, fix significant amounts of inorganic carbon into alginate, the most abundant polysaccharide found in their cell walls. Alginate serves as an important macromolecular carbon source for marine bacteria. The catabolism of alginate by bacteria is an important step in the marine carbon cycle, and this area of research has attracted growing interests over the past decade.

Experimental study on the nonlimit active earth pressure of finite soil in proximity engineering.

This study focuses on the active earth pressure distribution of finite soil masses in urban proximity engineering, with a specific emphasis on nonlimit conditions. Through laboratory model tests, the relationship between the nonlimit earth pressure and displacement of the finite soil mass is investigated. Furthermore, the distribution law of the nonlimit earth pressure is explored, considering the influence of the existing structure, proximity distance, and soil cover thickness of the existing structure on the nonlimit earth pressure distribution within the finite soil mass.

Pectin enhances the inhibition of α-amylase via the mixture of rutin and quercetin.

The human dietary system, which contains a variety of compounds such as polyphenols and polysaccharides, is very complex. Whether polysaccharides affect the inhibitory of polyphenol mixtures on α-amylase needs to be further investigated. The aim of this study was to analyze the effect and mechanism of pectin on the inhibition of α-amylase by a mixture of rutin and quercetin (R-Q).

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.

Background: To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.

Methods: Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).

Results: Higher CD4 TILs were correlated with favorable OS (HR=0.

Direct Preparation of Alginate Oligosaccharides from Brown Algae by an Algae-Decomposing Alginate Lyase AlyP18 from the Marine Bacterium A3.

Alginate oligosaccharides (AOs), derived from alginate degradation, exhibit diverse biological activities and hold significant promise in various fields. The enzymatic preparation of AOs relies on alginate lyases, which offers distinct advantages. In contrast to the conventional use of sodium alginate derived from brown algae as the substrate for the enzymatic preparation of AOs, AO preparation directly from brown algae is more appealing due to its time and energy efficiency.

Design of PEG-Based Hydrogels as Soft Ionic Conductors.

Conductive hydrogels have gained interest in biomedical applications and soft electronics. To tackle the challenge of ionic hydrogels falling short of desired mechanical properties in previous studies, our investigation aimed to understand the pivotal structural factors that impact the conductivity and mechanical behavior of polyethylene glycol (PEG)-based hydrogels with ionic conductivity. Polyether urethane diacrylamide (PEUDAm), a functionalized long-chain macromer based on PEG, was used to synthesize hydrogels with ionic conductivity conferred by incorporating ions into the liquid phase of the hydrogel.

The molecular subtypes of small cell lung cancer defined by key transcription factors and their clinical significance.

Background: Lung cancer, a prevalent and deadly malignancy, is classified into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC is further subdivided into four molecular subtypes-SCLC-A, SCLC-N, SCLC-P, and SCLC-I-based on key transcription factor expression.

Methods: Immunohistochemistry (IHC) was used to assess ASCL1, NEUROD1, and POU2F3 expression in tumor tissues.

Designing boron-doped carbon dot-functionalized COFs for fluorescence screening and liquid chromatography tandem mass spectrometry detection of toxins.

In recent years, mushroom poisoning has been one of the most important factors of food poisoning in China, timely identification of the toxins contained in mushrooms is crucial for the treatment of patients. In this study, boric acid carbon dots (BA-CDs) can undergo specific boron affinity reactions with amatoxins toxins containing o-dihydroxyl groups by means of boric acid groups. Functional covalent organic framework (COF) and BA-CDs were combined to design a adsorbent with boric acid group (COF@VBC@BA-CDs) was designed to meet the requirements of both fluorescent and pretreated materials for amatoxins.

A soft electronic skin simulating the multi-scale human touch for the detection of fruit freshness.

Realizing biomimicry for human tactile perception is a meaningful challenge. In this work, a soft matter system with multi-scale energy dissipation structure is designed to realize flexible sensing and detection by biomimetic human touch. At the molecular scale, the supramolecular interactions are introduced into the hydrogel system, including the hydrophobic interaction and the ion attraction between macromolecular segments.

Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical Trial.

Importance: Efficient approaches to prevent postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) are still needed.

Objective: To investigate whether partial cardiac denervation, achieved by cutting off the ligament of Marshall (LOM) and resecting the fat pad along the Waterston groove, can reduce the risk of POAF following CABG.

Design, Setting And Participants: This single-center, randomized clinical trial enrolled adult patients scheduled for isolated CABG in China.

An integrally formed Janus supramolecular bio-gel with intelligent adhesion for multifunctional healthcare.

Despite the rapid development of Janus adhesive hydrogels, most of them still entail complex fabrication processes and have the inherent flaws, such as fragility and instability, thereby restricting their biomedical applications. In this study, a novel Janus bio-gel with strong mechanical and intelligent adhesion functions is facilely fabricated through a gravity-driven settlement strategy, employing poly-cyclodextrin microspheres (PCDMs). This strategy takes advantage of the sedimentation behavior of PCDMs with various diameters to establish structural disparities on both sides of the Janus bio-gel, thereby resolving multiple predicaments including the tedious synthesis steps and poor bonding of multilayer hydrogels.

Mechanism insights and experimental feasibility of using boron nitride nanocones for rapid adsorption and degradation of SF decomposition compounds.

Gas-insulated switchgear (GIS) employs sulfur hexafluoride (SF) as an insulating medium to shield electrical gadget. However, SF can decompose under sure situations, generating dangerous sulfur-based totally compounds which include SO, SOF, and SOF. These byproducts pose enormous dangers to both protection and environmental integrity.

The relationship between fixed dental prostheses, blood lead levels, and liver function: Mediating effects and gender differences.

Metal alloys, pure titanium, metal-ceramics, and ceramic materials are used for fixed dental prostheses, which contained lead and potentially involved hepatotoxicity. To investigate the connection between fixed dental prostheses, blood lead levels, and liver function. A cross-sectional study enrolled 3624 American adults were conducted.