Fucoxanthin Induces Ferroptosis in Cancer Cells via Downregulation of the Nrf2/HO-1/GPX4 Pathway.

This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used to detect the inhibitory effects of fucoxanthin on SCC-25 human tongue squamous carcinoma cells. The levels of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured.

2-[(Adamantan-1-yl)amino-meth-yl]-4-chloro-phenol hemihydrate.

In the title compound, C17H22ClNO·0.5H2O, the water mol-ecule O atom resides on a twofold rotation axis. In the organic mol-ecule, the phenol group forms an intra-molecular O-H⋯N hydrogen bond.

(E)-N-Benzyl-ideneadamantan-1-amine.

In the title compound, C(17)H(21)N, the dihedral angle between the benzene ring and the imine group (-N=) is 5.1 (4)°. In the adamantane group, the C-C-C bond angles range from 107.

Tris(2-amino-pyridinium) hexa-chlorido-indate(III).

The Schiff base (E)-4-chloro-2-[(pyridin-2-yl-imino)-meth-yl]phenol was reacted with InCl(3)·4H(2)O, generating the title molecular salt, (C(5)H(7)N(2))(3)[InCl(6)]. The octa-hedral hexa-chlorido-indate(III) anion is located on an inversion centre, and one half of the anion and two crystallographically independent cations form the asymmetric unit. One of the cations is located on a twofold rotation axis and its intra-ring C and N atoms simulate this symmetry by exchanging their positions in statistical disorder.

rac-2-{[1-(1-Adamant-yl)eth-yl]imino-meth-yl}-5-meth-oxy-phenol.

A novel Schiff base compound, C(20)H(27)NO(2), was obtained by a condensation of rimantadine and 2-hy-droxy-4-meth-oxy-benzaldehyde. An intra-molecular O-H⋯N hydrogen bond supports the phenol-imine tautomeric form. The adamantane and imino-methyl-4-meth-oxy-phenol units are arranged in a folded conformation [C-N-C-C torsion angle = 110.

Therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome.

The aim of this present study is to evaluate the therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells (SCs) and bone marrow stromal cells (BMSCs) on a rat model of spinal cord hemi-section injuries (Brown-Séquard syndrome), which is relevant to human clinical spinal cord injury. Both in vivo and in vitro data we received demonstrated that co-transplantation BMSCs with NRG1-transfected SCs reduced the size of cystic cavities, promoted axonal regeneration and hind limb functional recovery in comparison with SCs or BMSCs transplantation alone or together, and this treatment could provide important insights into potential therapies of spinal cord hemi-section injuries.

[Predictors of massive blood transfusion in liver transplantation for patients with benign end-stage liver disease].

Objective: To identify the predictors of massive blood transfusion in liver transplantation for patients with benign end-stage liver disease (ESLD).

Methods: The clinical data of 268 patients with ESLD mainly caused by hepatitis B who were to receive cadaver liver transplantation performed by 5 groups of anesthesiologists respectively were retrospectively reviewed. The patients were divided into 2 groups according to the transfusion amount: massive blood transfusion (MBT) group (n = 120) receiving the blood transfusion of more than 12 units of red blood cells (RBCs) during the operation, and non-massive blood transfusion (NBT) group (n = 148).

Racial differences in coronary artery lesions: a comparison of coronary artery lesions between mainland Chinese and Australian patients.

Aims: The purpose of this study was to compare coronary lesions in mainland Chinese and Australians using coronary angiography (CAG).

Methods And Results: 6251 suspected coronary heart disease (CHD) patients (3021 Chinese patients from Nanjing and 3230 Australian patients from Sydney) who underwent a CAG between January 1, 2001, and December 31, 2003, were studied. Of these, 69.