A multicenter, randomized, parallel-controlled clinical trial protocol to evaluate the safety and efficacy of irreversible electroporation compared with radiofrequency ablation for the treatment of small hepatocellular carcinoma.

Background: At present, the main clinical application of local ablation therapy, such as radiofrequency ablation (RFA), is to heat the tissue to a certain temperature. However, high temperature will cause thermal damage. Irreversible electroporation (IRE) is a novel minimally invasive local ablation technology for tumors.

Research progress on pathogenesis of skin pigmentation in chronic liver disease.

Chronic liver disease (CLD) is a significant global health concern that leads to increased morbidity and mortality, and is associated with skin pigmentation changes. Excessive facial pigmentation is a common characteristic of patients with CLD, although the exact mechanism underlying this phenomenon remains unclear. Melanin, which consists of eumelanin and pheomelanin, is synthesized in melanocytes.

Electrospray whey protein-polysaccharide microcapsules co-encapsulating Lactiplantibacillus plantarum and EGCG: Enhanced probiotic viability and antioxidant activity.

Probiotics are often subjected to adverse factors during processing, storage and digestion. To enhance the viability and function of probiotics, whey protein concentrate (WPC)-based microcapsules were systematically fabricated to co-encapsulate probiotic Lactiplantibacillus plantarum KLDS 1.0328 (LP KLDS 1.

A review of the Segment Anything Model (SAM) for medical image analysis: Accomplishments and perspectives.

The purpose of this paper is to provide an overview of the developments that have occurred in the Segment Anything Model (SAM) within the medical image segmentation category over the course of the past year. However, SAM has demonstrated notable achievements in adapting to medical image segmentation tasks through fine-tuning on medical datasets, transitioning from 2D to 3D datasets, and optimizing prompting engineering. This is despite the fact that direct application on medical datasets has shown mixed results.

Long-term warming and acidification interaction drives plastic acclimation in the diatom Pseudo-nitzschia multiseries.

Ocean warming (OW) and acidification (OA) are expected to interactively impact key phytoplankton groups such as diatoms, but the underlying mechanisms, particularly under long-term acclimation, remain poorly understood. In this study, we investigated the responses of the toxic diatom Pseudo-nitzschia multiseries to combined changes in temperature (20 °C and 30 °C) and CO concentration (pCO 400 μatm and 1000 μatm) using a multi-omics approach over an acclimation period of at least 251 generations. Physiological data suggest that elevated temperature, either alone or in combination with CO, reduced the net photosynthesis and nitrate uptake rate, thus inhibiting P.

S-PLM: Structure-Aware Protein Language Model via Contrastive Learning Between Sequence and Structure.

Proteins play an essential role in various biological and engineering processes. Large protein language models (PLMs) present excellent potential to reshape protein research by accelerating the determination of protein functions and the design of proteins with the desired functions. The prediction and design capacity of PLMs relies on the representation gained from the protein sequences.

A telomere-to-telomere gap-free reference genome of provides insights into the molecular mechanism underlying petal shape changes.

, an arbor tree of the Oleaceae family, is an ecologically and economically valuable ornamental plant for its remarkable adaptability in landscaping. During breeding, we observed diverse floral shapes; however, no available genome for has hindered the widespread identification of genes related to flower morphology. Thus, a telomere-to-telomere (T2T) gap-free genome was generated.

Ecological risks of sulfonamides and quinolones degradation intermediates: Toxicity, microbial community, and antibiotic resistance genes.

The ecological risks posed by incompletely degraded antibiotic intermediates in aquatic environments warrant significant attention. This study investigated the degradation mechanisms of sulfonamides (sulfadiazine, sulfamethoxazole) and quinolones (ciprofloxacin, norfloxacin) during thermally activated persulfate (TAP) treatment. The main degradation mechanisms for sulfonamides involved S-N bond cleavage and -NH oxidation mediated by sulfate and hydroxyl radicals, whereas quinolone degradation occurred primarily through piperazine ring cleavage facilitated by a single linear oxygen.

Is ultrasound-guided radiofrequency ablation a reliable treatment option for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus: a retrospective comparative study based on large-sample data.

Objective: To evaluate whether ultrasound-guided radiofrequency ablation (RFA) is reliable for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus (PTCI).

Methods: 431 patients who underwent ultrasound-guided RFA for unifocal T1aN0M0 papillary thyroid carcinoma (PTC) were divided by location of the lesion into the PTCI group (52 females, 7 males, mean age 43.79 ± 12.

Sub-acute exposure of sea urchin (Strongylocentrotus intermedius) to environmentally relevant concentrations of PFOA and GenX influences gonadal development.

Perfluorooctanoic acid (PFOA) and its substitute, hexafluoropropylene oxide dimer acid (GenX), are widely used perfluorinated compounds (PFCs) that pose significant risks to marine ecosystems. However, the specific impacts of these contaminants on marine invertebrates, particularly echinoderms, remain poorly understood. Strongylocentrotus intermedius, a globally significant benthic aquacultural species, may be potentially affected by PFCs.

Digital mental health: a potential opportunity to improve health equity in China.

Mental health is an important public health issue in China, compounded by a shortage in psychiatric services. Against this backdrop, digital technologies could offer solutions. Digital mental health interventions use technologies, such as smartphone applications, to improve mental health outcomes.

Enhanced sludge solid-liquid separation based on Fe/periodate conditioning coupled with polyoxometalates: Cell destruction and protein adsorption.

Dewatering of waste activated sludge is a necessary step for achieving subsequent reduction, stabilization, and resource utilization. In this study, Fe/periodate (PI) coupled with polyoxometalates (POMs) conditioning was tested for realizing sludge deep dewatering. After the addition of POMs (0.

Identification of bioactive compounds with popular single-atom modifications: Comprehensive analysis and implications for compound design.

The extensive bioactivity data available in public databases, such as ChEMBL, has facilitated in-depth structure-activity relationship (SAR) analysis, which are essential for understanding the impact of molecular modifications on biological activity in a comprehensive manner. A central strategy in SAR analysis is the assessment of molecular similarity. Several approaches preferred by medicinal chemists have been developed to efficiently capture structurally related compounds on a large scale.

Reshaping the battlefield: A decade of clonal wars among Staphylococcus aureus in China.

Background: Long-term comprehensive studies on the genomic epidemiology of both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates are limited in China. Here, we aimed to assess the genomic epidemiological characteristics and population dynamics of S.

The neurotoxicity of acrylamide in ultra-processed foods: interventions of polysaccharides through the microbiota-gut-brain axis.

Ultra-processed foods (UPFs) have become popular in recent years, however, the detrimental effects of their excessive consumption have also become evident. Acrylamide (AA), a processing hazard present in UPFs, can further aggravate the harmful effects of UPFs. AA can cause significant damage to both the intestinal barrier and gut microbiota, thereby affecting the nervous system through the microbiota-gut-brain (MGB) axis.

Calcium Phosphate Loaded with Curcumin Prodrug and Selenium Is Bifunctional in Osteosarcoma Treatments.

Although SeO ions have been loaded onto calcium phosphate to treat a wide range of cancers, the quest to promote bone tissue regeneration is still ongoing. Curcumin (cur), an herbal extraction, can selectively inhibit tumor cells and promote osteogenesis. In this study, SeO ions were co-precipitated in biomimetic calcium phosphate (Se@BioCaP), and modified curcumin prodrug (mcur) was adsorbed on diverse Se@BioCaP surfaces (mcur-Se@BioCaP-Ads).

Green preparation of polydopamine-modified multiwalled carbon nanotube/calcium alginate composite aerogels for effective adsorption of methylene blue.

Polydopamine-modified multiwalled carbon nanotube/calcium alginate (P-CNTs/CA) aerogel was greenly prepared. The synthesis method of the P-CNTs/CA aerogel was evaluated for its environmental friendliness. SEM, FT-IR, Raman, TGA, BET, XPS, and Zeta potential characterized the P-CNTs/CA aerogel.

Deep learning based analysis of dynamic video ultrasonography for predicting cervical lymph node metastasis in papillary thyroid carcinoma.

Background: Cervical lymph node metastasis (CLNM) is the most common form of thyroid cancer metastasis. Accurate preoperative CLNM diagnosis is of more importance in patients with papillary thyroid cancer (PTC). However, there is currently no unified methods to objectively predict CLNM risk from ultrasonography in PTC patients.

Quantifying the Cooling Effect of Urban Greening Driven by Ecological Restoration Projects in China.

Urban greening (UG) affects local climate by altering surface energy balance, while long-term UG cooling potential, patterns, and contribution to curbing urban warming remain unclear. Here, we designed an novel statistical model to evaluate the cooling potential of UG (CPUG) and created the first CPUG map for China. By exploring the trends in observed and simulated urban surface temperatures (UST), we quantified the CPUG of 0.