Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer.

To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer (CRC) and the application value of carbon nanoparticle tracing. A total of 120 patients with CRC who underwent minimally invasive radical surgery were included. They were divided into groups according to whether they were grouped by carbon nano-tracers, and the baseline data were matched by propensity score method.

Unlocking curcumin's revolutionary: Improvement of stability and elderly digestion by soybean oil bodies and soybean protein-chitosan complex based Pickering emulsion.

Curcumin shows promise for disease prevention and health improvement, but its limited water solubility and vulnerability to degradation reduce its bioavailability, while its biological fate in elderly is unclear. Oil bodies are natural pre-emulsified oil droplets that serve as carriers for functional nutrients. In this study, soybean protein isolate (SPI) was complexed with chitosan (CS) for the purpose of stabilizing the soybean oil body-curcumin emulsion, resulting in the formation of the soybean isolate protein-chitosan-soybean oil bodies-curcumin Pickering emulsion (SPI-CS-SOB-C).

Automatic detection of multi-antibiotic residues simultaneously in aquatic products by visual protein microarray chips.

A 96-well microplate-based protein microarray chip which can simultaneously detect three different families of antibiotics using a multiplexed approach has been developed for the first time. All steps in the microarray chip can be completed through an automated biochip analyzer, enabling high throughput analysis of 96 samples within 60 min according to the set program. The microarray chip can be visually evaluated by the color depth of array points, and can also be quantified through a scanner.

Colorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.

Background: Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.

Methods: In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.

Strain-Mediated Second Harmonic Generation Enhancement of Bimetallic Metal-Organic Frameworks.

Triggered by the demand of developing practical metal-organic framework (MOF) based nonlinear optical (NLO) devices, there is a surge of research interest in the regulation of NLO properties of MOFs. Strain engineering provides a new opportunity to regulate the optoelectronic properties of materials and device performance at the interface. Here we introduce the induction of the strain field in structures by constructing bimetallic Zn/Cu-MOFs.

Research on the aperture angle-matched collimated illumination method for the dark-state light leakage of LCD target simulators.

Aiming at the problem of overbrightness of the target simulator background for LED backlight panel illumination, a 5° aperture angle-matched collimated illumination method for the target simulator is proposed based on the study of the dark-state leakage of the LCD display device and the scattered stray light of the system. After simulation analysis the method can make the display contrast increase by 3.1 times and solve the problem of dark targets being drowned by the background bright light, which exists in the LED illumination target simulator.

Infection with meningoencephalitis: A case report.

Background: Listeria meningitis is an infectious disease of the central nervous system caused by . This bacterium is widely present in the natural environment and can be transmitted through channels such as food and water. Patients usually show symptoms such as fever, headache, and neck stiffness.

Effects of Rice Root Development and Rhizosphere Soil on Methane Emission in Paddy Fields.

Paddy fields are important anthropogenic emission sources of methane (CH). However, it is not clear how rice root development and rhizosphere soil properties affect CH emissions. Therefore, we selected rice varieties with similar growth periods but different root traits in the local area.

The Effect of Vegetation Ecological Restoration by Integrating Multispectral Remote Sensing and Laser Point Cloud Monitoring Technology.

This research aims to evaluate and monitor the effectiveness of vegetation ecological restoration by integrating Multispectral Remote Sensing (MRS) and laser point cloud (LPC) monitoring technologies. Traditional vegetation restoration monitoring methods often face challenges of inaccurate data and insufficient coverage, and the use of MRS or LPC techniques alone has its limitations. Therefore, to more accurately monitor the vegetation restoration status, this study proposes a new monitoring method that combines the advantages of the large-scale coverage of MRS technology and the high-precision three-dimensional structural data analysis capability of LPC technology.

Biomechanic Differences Between Anticipated and Unanticipated Volleyball Block Jump: Implications for Lower Limb Injury Risk.

Volleyball is a high-intensity sport characterized by repetitive jumping, sudden directional changes, and overhead movements, all of which significantly increase the risk of injuries, particularly to the shoulders, knees, and ankles. Despite the frequency of injuries caused by actions like blocking and spiking, there has been limited research focused on the specific biomechanical risk factors unique to volleyball. This study aimed to investigate the lower limb biomechanics during block jumps in both the dominant and non-dominant directions, under both anticipated and unanticipated conditions, in fifteen elite male volleyball players.

Multiscale Modeling of Nanoparticle Precipitation in Oxide Dispersion-Strengthened Steels Produced by Laser Powder Bed Fusion.

Laser Powder Bed Fusion (LPBF) enables the efficient production of near-net-shape oxide dispersion-strengthened (ODS) alloys, which possess superior mechanical properties due to oxide nanoparticles (e.g., yttrium oxide, Y-O, and yttrium-titanium oxide, Y-Ti-O) embedded in the alloy matrix.

ChIP-Seq Analysis of AtfA Interactions in Reveals Its Involvement in Aflatoxin Metabolism and Virulence Under Oxidative Stress.

The risk of contamination is expanding with global warming. Targeting the pathogenicity of at its source and diminishing its colonization within the host may be a potential control strategy. Oxidative stress transcription factor AtfA plays a pivotal role in pathogenicity by combating reactive oxygen species (ROS) generated by host immune cells.

A novel human protein-coding locus identified using a targeted RNA enrichment technique.

Background: Accurate and comprehensive genomic annotation, including the full list of protein-coding genes, is vital for understanding the molecular mechanisms of human biology. We have previously shown that the genome contains a multitude of yet hidden functional exons and transcripts, some of which might represent novel mRNAs. These results resonate with those from other groups and strongly argue that two decades after the completion of the first draft of the human genome sequence, the current annotation of human genes and transcripts remains far from being complete.

Study on secondary collapse of the bottom frame masonry structure in semi-ruined state based on FEM-FDEM.

The bottom frame masonry structure (BFMS) in a semi-ruined state is vulnerable to secondary collapse under strong aftershocks, posing a significant risk to rescuers during post-earthquake operations. Therefore, investigating the mechanisms and characteristics of secondary collapse of BFMS in a semi-ruined state (BFMS-SR) under aftershocks is critical. This paper proposes a numerical modeling framework for BFMS under mainshock-aftershock conditions, utilizing a combination of the finite element method (FEM) and the finite discrete element method (FDEM).

The Environmental Hazards and Treatment of Ship's Domestic Sewage.

With the rapid development of the modern shipping field, the damage caused by ship pollution to the global inland waterways and marine ecosystems has attracted extensive attention from the international community. However, there are fewer reviews on the environmental hazards of domestic ship sewage and its treatment, and a systematic summary of the environmental hazards posed by ship domestic sewage and its treatment is lacking. Based on summarizing the various environmental hazards brought about by a ship's domestic sewage and the corresponding treatment methods, this study elaborates, in detail, on the specific hazards of the main toxic and hazardous substances contained in a ship's domestic sewage on the environment and organisms, and the treatment methods of the ship's domestic sewage and their treatment effects, such as membrane bioreactor (MBR).

Calcium Phosphate Loaded with Curcumin Prodrug and Selenium Is Bifunctional in Osteosarcoma Treatments.

Although SeO ions have been loaded onto calcium phosphate to treat a wide range of cancers, the quest to promote bone tissue regeneration is still ongoing. Curcumin (cur), an herbal extraction, can selectively inhibit tumor cells and promote osteogenesis. In this study, SeO ions were co-precipitated in biomimetic calcium phosphate (Se@BioCaP), and modified curcumin prodrug (mcur) was adsorbed on diverse Se@BioCaP surfaces (mcur-Se@BioCaP-Ads).

Predicted Spatial Patterns of Suitable Habitats for Under Different Climate Scenarios.

is the largest butterfly in China and is highly valued for its ornamental beauty. Due to being classified as a national second-class protected species in China, studying its spatial distribution is crucial for developing effective conservation measures. In this study, a total of 490 distribution points were obtained, and the potential distribution areas of the golden-sheathed were analyzed by using the maximum entropy model (MaxEnt) based on three different greenhouse gas emission scenarios, namely, SSP1-2.

Computational Insights into Acrylamide Fragment Inhibition of SARS-CoV-2 Main Protease.

The pathogen of COVID-19, SARS-CoV-2, has caused a severe global health crisis. So far, while COVID-19 has been suppressed, the continuous evolution of SARS-CoV-2 variants has reduced the effectiveness of vaccines such as mRNA-1273 and drugs such as Remdesivir. To uphold the effectiveness of vaccines and drugs prior to potential coronavirus outbreaks, it is necessary to explore the underlying mechanisms between biomolecules and nanodrugs.

Safety and efficacy of generic nab-paclitaxel-based therapy in Chinese patients with malignant tumors in a real-world setting: a multicenter prospective observational study.

Objective: This study aimed to assess the safety and efficacy of generic nab-paclitaxel in the Chinese population in a real-world setting.

Methods: This prospective, multicenter, observational study enrolled patients with malignancies who received any generic nab-paclitaxel-based regimens in China. The primary endpoint was safety, and secondary endpoint was objective response rate (ORR).

Bibliometric analysis of research hotspots and trends on the relationship between the gut microbiota and depression from 2020 to 2024.

Introduction: In recent years, an increasing body of research has illustrated a strong correlation between gut microbiota and depression. However, there has yet to be a comprehensive discussion or summary of the latest advancements and trends in this field.

Methods: We retrieved research articles focused on gut microbiota and depression through the WOS database from 2020 to 2024, using visual text analysis tools such as CiteSpace and VOSviewer.

Discovery of potential female-specific biomarkers for major depressive disorder by LC-MS-based metabolomics.

The prevalence of major depressive disorder (MDD) is higher in females than males, emphasizing the need to identify gender-specific biomarkers to improve diagnosis accuracy. In this study, a cross-sectional investigation with 258 samples was conducted to evaluate the discriminative power of potential gender-specific biomarkers for MDD. Eighteen MDD-related differential metabolites have been identified, involving pathways of phospholipids, glycerolipids, fatty acids, sphingolipids, cholesterol, vitamin E, and heme.