Association between promoter hypermethylation of the DACT2 gene and tumor stages in breast cancer.

Purpose: Aberrant methylation of CpG islands in the promoter is a hallmark of cancer, leading to transcriptional silencing of tumor suppressor genes. The aim of this work was to evaluate the promoter methylation status of the DACT2 gene in breast cancer (BC) tissue and to analyze its possible effect on tumor type or grade.

Methods: CpG island from the DACT2 promoter in region -240 to -14 from transcriptional start site (TSS) were obtained.