Publications by authors named "Xizi Zheng"

Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. Here we show a simple, real-time, interpretable AKI prediction model for general hospitalized patients developed from a large tertiary hospital in China, which has been validated across five independent, geographically distinct, different tiered hospitals.

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Introduction: Ischemia-reperfusion injury (IRI) is detrimental to kidney transplants and may contribute to poor long-term outcomes of transplantation. Programmed cell death (PCD), a regulated cell death form triggered by IRI, is often indicative of an unfavorable prognosis following transplantation. However, given the intricate pathophysiology of IRI and the considerable variability in clinical conditions during kidney transplantation, the specific patterns of cell death within renal tissues remain ambiguous.

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  • The study investigates the link between statin use and in-hospital mortality in patients with acute kidney injury (AKI).
  • Statin users showed a significantly lower risk of overall and cardiovascular-related mortality compared to nonusers, with the most notable benefit seen from atorvastatin.
  • The findings suggest that using statins, particularly atorvastatin, may enhance survival rates in hospitalized AKI patients, although the benefits didn't extend to other complications like sepsis-related mortality or kidney recovery rates.
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  • The study investigates the relationship between circulating immune cells and diabetic kidney disease (DKD) using Mendelian randomization and immune cell analysis.
  • It identifies ten immune traits associated with DKD, with specific B and T cell characteristics linked to either promoting or protecting against the disease.
  • The findings suggest that certain B cell types play a crucial role in DKD and highlight a decrease in memory B cells in DKD patients compared to those with diabetes but without kidney disease.
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: Acute kidney injury (AKI), a prevalent postoperative complication, predominantly manifests as stage 1, characterized by a mild elevation in serum creatinine (SCr). There is yet to be a consensus regarding the association between stage 1 AKI and adverse outcomes in surgical patients. This retrospective study enrolled adult patients who underwent at least one surgery during hospitalization from the MIMIC IV database.

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Background: Acute kidney injury (AKI) is a severe postoperative complication in patients undergoing major surgery. Proton pump inhibitors (PPIs) are used preoperatively as prophylaxis for postoperative gastrointestinal bleeding. Whether preoperative PPI use is associated with an increased risk of postoperative AKI remains uncertain.

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Aim: Both excessive intake of sodium and inadequate intake of potassium are associated with blood pressure elevation and subsequent increase in the risk of cardiovascular disease, which accounts for the largest number of deaths in China and worldwide. Low sodium salt, a mixture of mainly sodium chloride and potassium chloride, has shown its great potential as a promising population strategy for sodium intake reduction through multiple large-scale, multicenter, randomized controlled trials among populations including patients with cardiovascular disease, individuals with and without hypertension, older and younger adults, and men and women in China and other countries. This Guidelines aims to provide expert recommendations for promotion and use of low sodium salt in China, based on the current available scientific evidence regarding the effectiveness, safety, cost-effectiveness, and acceptability of low sodium salts in various population groups and different application scenarios.

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Background: Kidney involvement is common in hospitalized coronavirus disease 2019 (COVID-19) patients during the acute phase, little is known about the long-term impact of COVID-19 on the kidney.

Methods: This is a systematic review and meta-analysis on long-term renal outcomes among COVID-19 patients. We carried out a systematic literature search in PUBMED, EMBASE, SCOPUS, and Cochrane COVID-19 study register and performed the random-effects meta-analysis of rates.

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(1) Background: Despite increasing recognition of immune checkpoint inhibitors (ICIs) and kidney immune-related adverse events (IRAEs), no large-sample studies have assessed the pathological characteristics and outcomes of biopsy-proven kidney IRAEs. (2) Methods: We comprehensively searched PubMed, Embase, Web of Science, and Cochrane for case reports, case series, and cohort studies for patients with biopsy-proven kidney IRAEs. All data were used to describe pathological characteristics and outcomes, and individual-level data from case reports and case series were pooled to analyze risk factors associated with different pathologies and prognoses.

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  • Sepsis leads to severe organ dysfunction, with sepsis-associated acute kidney injury (S-AKI) being a major complication that increases patient mortality, making its prevention and treatment a critical issue.* -
  • In experiments involving septic mice, injections of human amnion epithelial cells (hAECs) and their exosomes (EXOs) after induced sepsis showed a significant decrease in mortality and improved kidney function by suppressing inflammation and maintaining kidney cell integrity.* -
  • The study suggests that both hAECs and their EXOs effectively protect kidney health in the context of sepsis by inhibiting inflammatory pathways, indicating their potential as therapeutic options for S-AKI.*
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  • The study explored the role of resting heart rates (RHRs) in COVID-19 patients, revealing that higher RHRs were linked to worse health outcomes.
  • Among 136 patients, those with RHRs over 100 bpm had lower oxygen levels, higher temperatures, and exhibited various markers indicating worse health status.
  • The findings indicated that elevated RHRs, especially tachycardia, were significant independent predictors of higher mortality and increased need for ventilators in these patients.
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Background And Objectives: The pandemic of coronavirus disease 2019 (COVID-19) remains to be the biggest public threat all over the world. Because of the rapid deterioration in some patients, markers that could predict poor clinical outcomes are urgently required. This study was to evaluate the predictive values of cardiac injury parameters, including cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, on mortality in COVID-19 patients.

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Background: Clinical decision support systems including both electronic alerts and care bundles have been developed for hospitalized patients with acute kidney injury.

Methods: Electronic databases were searched for randomized, before-after and cohort studies that implemented a clinical decision support system for hospitalized patients with acute kidney injury between 1990 and 2019. The studies must describe their impact on care processes, patient-related outcomes, or hospital length of stay.

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Purpose: This study aims to detail the characteristics of chemotherapy-related acute kidney injury (CR-AKI) and investigate its effect on patient outcomes.

Methods: This is a multicenter cross-sectional study of cancer patients with CR-AKI screened from hospital-acquired adult AKI patients based on a nationwide AKI survey in China.

Results: Of the 3468 patients with hospital-acquired AKI, 258 cases of CR-AKI were identified.

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Coronavirus disease 2019 (COVID-19) has resulted in more than 610,000 deaths worldwide since December 2019. Given the rapid deterioration of patients' condition before death, markers with efficient prognostic values are urgently required. During the treatment process, notable changes in plasma potassium levels have been observed among severely ill patients.

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Article Synopsis
  • * AKI is linked to the seriousness of COVID-19 and higher mortality, primarily affecting the renal tubules, with various causes such as direct viral effects and complications like hypoxia.
  • * Current treatment options are limited, and there's a pressing need for more research on kidney-related issues in COVID-19 to find effective treatments and understand the injury mechanisms better.
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  • TINU (tubulointerstitial nephritis and uveitis) is a rare autoimmune disorder that can occur alongside other conditions, such as thrombotic microangiopathy (TMA), and this case study discusses a 37-year-old male who experienced both.
  • The patient suffered from acute kidney injury linked to malignant hypertension-induced TMA, which was later complicated by TINU suspected to be caused by medication hypersensitivity, and he responded positively to treatments including prednisone and cyclophosphamide.
  • The study highlights the importance of kidney biopsies for accurate diagnoses in cases of acute kidney injury and emphasizes the need for ongoing monitoring and potentially extended treatment with prednisone for patients diagnosed with TINU.
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Background: The current worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, and the mortality rate of critical ill patients remains high. The purpose of this study was to identify factors that early predict the progression of COVID-19 from severe to critical illness.

Methods: This retrospective cohort study included adult patients with severe or critical ill COVID-19 who were consecutively admitted to the Zhongfaxincheng campus of Tongji Hospital (Wuhan, China) from February 8 to 18, 2020.

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Background: A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindications, refusal of informed consent and limited technical support may stop the biopsy process. It is thus of great importance to explore approaches that could deduce probable pathologic changes.

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  • Acute kidney injury (AKI) is a prevalent clinical issue with complicated underlying mechanisms and few treatment options, creating a need for new approaches; human amnion epithelial cells (hAECs) and their exosomes (hAECs-EXO) show promise as potential therapies.
  • In an ischemia-reperfusion mouse model of AKI, hAECs improved kidney function and survival rates while reducing cell death and promoting healthy immune responses, although they did not integrate well into kidney tissue.
  • hAECs-EXO replicated the protective effects of hAECs in vitro by preventing cell apoptosis and supporting the polarization of macrophages towards a protective phenotype, with proteomic analysis revealing key proteins that could contribute to kidney repair
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  • A study was conducted to examine kidney injuries in COVID-19 patients and their link to disease progression and mortality.
  • The research involved 555 patients from two locations in China, identifying that 42% had some form of kidney injury, with the most common being proteinuria and hematuria.
  • The findings revealed that patients with kidney injuries had significantly higher death rates, especially those with acute kidney injury (AKI), with hazard ratios indicating a strong association between these conditions and patient mortality.
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Background: Oxidative stress has been identified as an important pathogenesis mechanism in the development of renal interstitial fibrosis in unilateral ureteral obstruction (UUO). Previous studies have demonstrated increased expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOXs) in response to UUO. We aimed to investigate whether NOXs activation was involved in the development of renal fibrosis in UUO by contribution to oxidative stress and the potential mechanism in the present study.

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