Publications by authors named "Xizi Su"
Background: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limited research on the role of the variation of metabolic enzymes in this process.
Methods: We carried out a study including 752 participants, measured the concentrations of 16 kinds PAHs in both particle and gaseous phases, urinary PAHs metabolites, leukocyte BPDE-DNA adduct and serum BPDE- Albumin (BPDE-Alb) adduct, and calculated daily intake dose (DID) to assess the cumulative exposure of PAHs.
Article Synopsis
- Epidemiological studies link fine particulate matter (PM) exposure to increased hypertension, but the exact mechanisms and contributions of PM components to blood pressure elevation are still unclear.
- The research conducted on workers exposed to high and low PM levels reveals that increased PM leads to significant rises in systolic blood pressure (SBP) and pulse pressure (PP), with specific contributions from urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cobalt.
- The study highlights the platelet-to-lymphocyte ratio (PLR) as a mediator in the relationship between cobalt exposure and elevated blood pressure, emphasizing the need for improved monitoring of harmful PM constituents to protect cardiovascular health.