Review of directional leads, stimulation patterns and programming strategies for deep brain stimulation.

Deep brain stimulation (DBS) is a well-established treatment for both neurological and psychiatric disorders. Directional DBS has the potential to minimize stimulation-induced side effects and maximize clinical benefits. Many new directional leads, stimulation patterns and programming strategies have been developed in recent years.

Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors.

Particulate matter (PM) has always received widespread attention, PM2.5 pollution is associated with many adverse effects, including cardiovascular, respiratory and metabolic diseases and mood disorders. However, the underlying mechanisms are not yet clear.

Prevention and alleviation of allergic rhinitis by oral administration of GOLDGUT-Lpc969.

Introduction: Allergic rhinitis (AR) is a widespread upper airway disorder characterized by inflammation of the nasal passages. It is immunologically mediated via the hypersensitivity type I mechanism, which is primarily elicited by the immunoglobulin E (IgE)-linking allergen-induced imbalance of the Th2/Th1 immune response. Owing to the limited efficacy of current medications, probiotics have received attention for their potential in preventing and ameliorating AR.

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Deep Brain Stimulation Currents.

Deep brain stimulation (DBS) is an effective treatment for neurologic disease and its clinical effect is highly dependent on the DBS leads localization and current stimulating state. However, standard human brain imaging modalities could not provide direct feedback on DBS currents spatial distribution and dynamic changes. Acoustoelectric brain imaging (AEBI) is an emerging neuroimaging method that can directly map current density distribution.

The frontooccipital interaction mechanism of high-frequency acoustoelectric signal.

Based on acoustoelectric effect, acoustoelectric brain imaging has been proposed, which is a high spatiotemporal resolution neural imaging method. At the focal spot, brain electrical activity is encoded by focused ultrasound, and corresponding high-frequency acoustoelectric signal is generated. Previous studies have revealed that acoustoelectric signal can also be detected in other non-focal brain regions.

Multielectrode Array-Based Percutaneous Nerve Stimulation Strategy With Ultrasound Guidance for Ulnar Nerve Injury.

Studies have shown that percutaneous nerve stimulation can promote repair of ulnar neuropathy. However, this approach requires further optimization. We evaluated multielectrode array-based percutaneous nerve stimulation for treatment of ulnar nerve injury.

An adaptive acoustoelectric signal decoding algorithm based on Fourier fitting for brain function imaging.

Acousticelectric brain imaging (ABI), which is based on the acoustoelectric (AE) effect, is a potential brain function imaging method for mapping brain electrical activity with high temporal and spatial resolution. To further enhance the quality of the decoded signal and the resolution of the ABI, the decoding accuracy of the AE signal is essential. An adaptive decoding algorithm based on Fourier fitting (aDAF) is suggested to increase the AE signal decoding precision.

Numerical Simulation Study of Firing Threshold of STN Neuron Stimulated by Focused Ultrasound.

Objective: Electroencephalography (EEG) is one of the functional brain imaging techniques to effectively measure neuronal activity, but its low spatial resolution makes it difficult to localize evoked excitatory neurons or areas of abnormal firing. Multimodal imaging techniques are expected to combine the high spatial resolution (mm level) of focused ultrasound (FUS) with the high temporal resolution (ms level) of EEG. The technique must be performed under the premise that ultrasound stimulation does not affect neuronal firing, and there is an urgent need to determine the threshold of this ultrasound stimulation parameter.

Case report: Ultrasound-guided multi-site electroacupuncture stimulation for a patient with spinal cord injury.

Introduction: Spinal cord injury causes permanent neurological deficits, which have devastating physical, social, and vocational consequences for patients and their families. Traditional Chinese medicine uses acupuncture to treat neuropathic pain and improve nerve conduction velocity. This treatment can also reduce peripheral nerve injury joint contracture and muscle atrophy in affected patients.

The processing network of high-frequency acoustoelectric signal in the living rat brain.

Acoustoelectric brain imaging (ABI) is a potential noninvasive electrophysiological neuroimaging method with high spatiotemporal resolution. At the focal spot of the focused ultrasound, with the couple of acoustic and electric fields, high-frequency acoustoelectric (HF AE) signal is generated. Because the brain is a volume conductor, HF AE signal can be detected in other brain cortex.

An ultrasound-guided percutaneous electrical nerve stimulation regimen devised using finite element modeling promotes functional recovery after median nerve transection.

Percutaneous electrical nerve stimulation of an injured nerve can promote and accelerate peripheral nerve regeneration and improve function. When performing acupuncture and moxibustion, locating the injured nerve using ultrasound before percutaneous nerve stimulation can help prevent further injury to an already injured nerve. However, stimulation parameters have not been standardized.

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Steady-State Visual Stimulation Paradigms.

Objective: Based on the acoustoelectric (AE) effect, transcranial acoustoelectric brain imaging (tABI) is of potential for brain functional imaging with high temporal and spatial resolution. With nonlinear and non-steady-state, brain electrical signal is microvolt level which makes the development of tABI more difficult. This study demonstrates for the first time in vivo tABI of different steady-state visual stimulation paradigms.

Biological current source imaging method based on acoustoelectric effect: A systematic review.

Neuroimaging can help reveal the spatial and temporal diversity of neural activity, which is of utmost importance for understanding the brain. However, conventional non-invasive neuroimaging methods do not have the advantage of high temporal and spatial resolution, which greatly hinders clinical and basic research. The acoustoelectric (AE) effect is a fundamental physical phenomenon based on the change of dielectric conductivity that has recently received much attention in the field of biomedical imaging.

Experimental and simulation studies of localization and decoding of single and double dipoles.

. Electroencephalography is a technique for measuring normal or abnormal neuronal activity in the human brain, but its low spatial resolution makes it difficult to locate the precise locations of neurons due to the volume conduction effect of brain tissue..

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation.

Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused on the pathophysiological changes within a single injury site. However, recent studies have indicated that within the central nervous system, PNI can lead to changes in both injury sites and target organs at the cellular and molecular levels. Therefore, the basic mechanisms of PNI have not been comprehensively understood.

Mathematical Model of Ultrasound Attenuation With Skull Thickness for Transcranial-Focused Ultrasound.

Transcranial-focused ultrasound (tFUS) has potential for both neuromodulation and neuroimaging. Due to the influence of head tissue, especially the skull, its attenuation is a key issue affecting precise focusing. The objective of the present study was to construct a mathematical model of ultrasound attenuation inclusive of skull thickness.

Corrigendum: Performance Improvement for Detecting Brain Function Using fNIRS: A Multi-Distance Probe Configuration With PPL Method.

[This corrects the article DOI: 10.3389/fnhum.2020.

The Effects of the Structural and Acoustic Parameters of the Skull Model on Transcranial Focused Ultrasound.

Transcranial focused ultrasound (tFUS) has great potential in brain imaging and therapy. However, the structural and acoustic differences of the skull will cause a large number of technical problems in the application of tFUS, such as low focus energy, focal shift, and defocusing. To have a comprehensive understanding of the skull effect on tFUS, this study investigated the effects of the structural parameters (thickness, radius of curvature, and distance from the transducer) and acoustic parameters (density, acoustic speed, and absorption coefficient) of the skull model on tFUS based on acrylic plates and two simulation methods (self-programming and COMSOL).