Background: Alzheimer's disease neuropathologic changes (AD-NC) are important to identify people with high risk for AD dementia (ADD) and subtyping ADD.
Objective: Develop imputation models based on clinical measures to infer AD-NC.
Methods: We used penalized generalized linear regression to train imputation models for four AD-NC traits (amyloid-β, tangles, global AD pathology, and pathologic AD) in Rush Memory and Aging Project decedents, using clinical measures at the last visit prior to death as predictors.
Background: Alzheimer's disease neuropathologic changes (AD-NC) are important for identify people with high risk for AD dementia (ADD) and subtyping ADD.
Objective: Develop imputation models based on clinical measures to infer AD-NC.
Methods: We used penalized generalized linear regression to train imputation models for four AD-NC traits (amyloid-, tangles, global AD pathology, and pathologic AD) in Rush Memory and Aging Project decedents, using clinical measures at the last visit prior to death as predictors.
Birds select suitable nest sites for breeding to ensure their own and offspring's survival; however, they inevitably suffer some potential predation risk. We studied the breeding ecology of Daurian redstarts () by providing nest boxes for their breeding from March to August of 2022. We recorded the predation of both Daurian redstarts eggs or nestlings by Oriental magpie-robins () and tree sparrow ().
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a progressive disorder without a cure. Develop risk prediction models for detecting presymptomatic AD using non-cognitive measures is necessary to enable early interventions.
Objective: Examine if non-cognitive metrics alone can be used to construct risk models to identify adults at risk for AD dementia and cognitive impairment.