[Clinical and genetic analysis of a Chinese pedigree affected with type 2 Long QT syndrome due to variant of KCNH2 gene].

Objetive: To explore the clinical and genetic etiology of a Chinese pedigree affected with type 2 Long QT syndrome (LQTS).

Methods: A pedigree with type 2 LQTS presented at Fuwai Central China Cardiovascular Hospital on August 23, 2019 was selected as the study subject. Peripheral blood samples were collected from the proband and her parents.

Linking teacher support to achievement emotion profile: the mediating role of basic psychological need satisfaction.

The current study used a person-centered approach to explore the co-occurrence of college students' achievement emotions. It also examined the impact of teacher support on achievement emotion profiles and the mediating effect of need satisfaction. A total of 866 college students participated in the survey.

Work pressure, coping styles and occupational burnout among Chinese police officers: a meta-analytic review.

The present study conducted a comprehensive meta-analysis to systematically review the relationship between occupational burnout and work pressure among Chinese police officers. Additionally, the study explored the mediating role of coping styles using a meta-analytic structural equation model. The investigation involved a thorough search of CNKI, PubMed, PsychInfo, Web of Science, and Google Scholar databases, resulting in the identification of a total of 39 studies with 124 effect sizes and 14,089 police officers.

Analysis of risk factors and short-term prognostic factors of arrhythmia in patients infected with mild/moderate SARS-CoV-2 Omicron variant.

Background: Complications, including arrhythmia, following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continue to be of concern. Omicron is the mainstream SARS-CoV-2 mutant circulating in mainland China. At present, there are few epidemiological studies concerning the relationship between arrhythmia and Omicron variant infection in mainland China.

Parental and Adolescent Educational Expectations and Adolescent Problem Behaviors: The Role of Deviant Peer Affiliations.

The comprehensive theory model of problem behaviors proposed that expectations are important factors affecting adolescent problem behaviors. The purpose of this study is to explore the association between educational expectations (in this study, this includes parental educational expectations and adolescent selfeducational expectations) and problem behaviors based on the framework of the CTMPB to provide empirical support for the prevention and intervention of adolescent problem behaviors. This study used cross-sectional data from the 2014-2015 academic year of the China Education Panel Survey (CEPS) conducted by the China survey and data center at the Renmin University of China.

Linking Cognitive Reappraisal and Expressive Suppression to Mindfulness: A Three-Level Meta-Analysis.

Cognitive reappraisal and expressive suppression have long been considered the two most important emotion regulation strategies. Increasingly, studies have found that mindfulness has a relationship with them. However, the magnitude and direction of the relationship between them have yet to reach a consistent conclusion.

Problem Behaviors of Adolescents: The Role of Family Socioeconomic Status, Parental Educational Expectations, and Adolescents' Confidence in the Future.

The comprehensive theoretical model of problem behaviors proposes that family socioeconomic status is one of the factors affecting adolescent problem behaviors. The purpose of this study is to further explore the mechanism of the influence of family socioeconomic status on adolescent problem behaviors based on the framework of the comprehensive theoretical model of problem behaviors. Further, it is to discover more protective or risk factors affecting adolescent problem behaviors, so as to provide theoretical guidance for the prevention of and intervention in adolescent problem behaviors.

Parents' Response to Children's Performance and Children's Self-Esteem: Parent-Child Relationship and Friendship Quality as Mediators.

Previous research has revealed that parents' success-oriented response to children's performance promotes children's self-esteem, while failure-oriented response damages their self-esteem. However, the potential mediating mechanisms are unclear. Therefore, the present study investigated whether parent-child relationship and friendship quality mediated the relation between parents' response to children's performance and children's self-esteem.

The Relationship between Empathy and Attachment in Children and Adolescents: Three-Level Meta-Analyses.

Empathy is one of the leading social abilities to understand or feel the emotions of other people. Attachment is thought to be a critical influential factor of empathy, as revealed by attachment theory and experimental studies, while empathy is also believed to facilitate the quality of attachment. Although many studies are conducted concerning the two subjects, the direction and magnitude of their relationship still remain unclear.

Predictors of Recurrent Hospital Admission for Patients Presenting With Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State.

Background: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two serious, preventable complications of diabetes mellitus. Analysis of variables associated with recurrent DKA and HHS admission has the potential to improve patient outcomes by identifying possible areas for intervention. The aim of this study was to evaluate potential predictors of recurrent DKA or HHS admission.

Recombinant adeno-associated virus-mediated delivery of antisense angiotensin II receptor 1 gene attenuates hypertension development.

Aim: The renin-angiotensin system plays a crucial role in the development and establishment of hypertension, and the pharmacological blockade of the system results in a reduction in blood pressure. In the present study, we investigated whether the effects of a novel, double-stranded, recombinant adeno-associated virus vector (rAAV)-mediated antisense angiotensin II receptor 1 (AT1R) gene efficiently prevents the development of hypertension induced by a high-salt diet in adult, male Sprague-Dawley (SD) rats.

Methods: A rAAV was prepared with a cassette containing a cytomegalovirus promoter and partial cDNA (660 base pairs) for the AT1R inserted in the antisense direction (rAAV-AT1-AS).

Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways.

We previously reported that iv delivery of the human tissue kallikrein (HK) gene reduced blood pressure and plasma insulin levels in fructose-induced hypertensive rats with insulin resistance. In the current study, we evaluated the potential of a recombinant adeno-associated viral vector expressing the HK cDNA (rAAV-HK) as a sole, long-term therapy to correct insulin resistance and prevent renal damage in streptozotocin-induced type-2 diabetic rats. Administration of streptozotocin in conjunction with a high-fat diet induced systemic hypertension, diabetes, and renal damage in rats.