Optimal pathways involved in the treatment of sevoflurane or propofol for patients undergoing coronary artery bypass graft surgery.

The cardio-protection mechanisms of sevoflurane and propofol still remain unclear in patients undergoing coronary artery bypass grafting (CABG). We designed the present study to identify the optimal pathways through integrating differential co-expressed network (DCN)-based guilt by association (GBA) principle based on the expression data of E-GEOD-4386 downloaded from EMBL-EBI. Differentially expressed genes (DEGs) were firstly identified and then DCN and sub-DCN were established.

[Clinical features and risk factors of anastomotic leakage after radical esophagectomy].

Objective: To analyze the clinical features and risk factors of anastomotic leakage after radical esophagectomy of esophageal carcinoma.

Methods: The clinical data of 547 esophageal cancer patients underwent radical esophagectomy in Tianjin Medical University Cancer Hospital from January 2012 to December 2013 was analyzed retrospectively. There were 421 male and 126 female patients, with a median age of 65 years (ranging from 29 to 82 years).

Is tumor length a prognostic indicator for esophageal squamous cell carcinoma? A single larger study among Chinese patients.

Objective: In esophageal cancer, depth of wall penetration, reflected by T classification, represents the most important prognostic variable. Our study aimed to investigate the impact of tumor length, measured as the longitudinal length, on the outcome of esophageal squamous cell carcinoma (ESCC) patients.

Methods: The survival data of 362 ESCC patients who underwent surgical resection as the primary treatment between 1999 and 2007 were collected retrospectively.

[Application of Ivor-Lewis esophagectomy in elderly patients with carcinoma in middle and lower esophagus].

Objective: To evaluate the safety of Ivor-Lewis procedure for middle and lower esophageal carcinoma in the elderly.

Methods: From June 2009 to June 2010, 232 cases aged over 60 years were diagnosed as esophageal carcinoma. These cases were randomly divided into two groups using table of random digits.

Resection of primary sternal osteosarcoma and reconstruction with homologous iliac bone: case report.

Primary sternal osteosarcoma is rare and has a poor prognosis. Here, we describe the case of a 44-year-old man with sternal osteosarcoma. He underwent subtotal sternectomy with partial resection of the bilateral ribs and left clavicle.

[RNA interference silencing excision repair cross-complementing 1 gene and affecting cisplatin sensitivity on lung cancer cell lines].

Objective: To research the changes of cisplatin sensitivity by RNA interfering the excision repair cross-complementing (ERCC)1 gene in lung cancer cell lines.

Methods: The small interference RNA (siRNA) targeting ERCC1 gene was designed and synthesized by transcription in vitro, and transfected to lung cancer cell line A549. The mRNA and protein of ERCC1 were evaluated by means of RT-PCR, Western blot and immunocytochemistry.

[Comparative analysis of sleeve resection and pneumonectomy for lung cancer].

Background: Sleeve recestion for lung cancer can get similar tumor and lymph node resection rate as pneumonectomy, with less influence on pulmonary function and much improvement of quality of life. The aim of this study is to compare the 5-year survival and complications of sleeve resection and pneumonectomy for lung cancer.

Methods: Survival analysis was used to investigate the 5-year survival of 173 patients undergoing sleeve resection and 435 patients undergoing pneumonectomy from January 1990 to December 2000.

[Clinical analysis of the characteristics of thoracic lymph node metastasis in lung cancer: A report of 318 cases].

Background: To investigate the clinical characteristics of thoracic lymph node metastasis in lung cancer.

Methods: Three hundred and eighteen patients with lung cancer underwent pneumonectomy or lobectomy and lymphadenectomy from Jan 2000 to Jan 2002.

Results: A total of 1534 groups of lymph nodes were removed.

[Guideline of surgical practice for non-small cell lung cancer based staging].

The clinical evidences of the guideline came from clinical trials based evidence-based medicine. Applied principle of the evidence was: systematic reviews, RCTs, the results from multiple factors ana-lysis, consensus, especially combined with Chinese experience and some lung cancer guidelines used in USA or Europe. All doctors who use the guideline in making therapeutic strategy must combine patients' conditions with the knowledge of biological behavior, dynamic change and response to treatment of lung cancer.

[Generation of T cell-mediated antitumor response in vitro by autologous dendritic cells pulsed with tumor lysates in patients with non-small cell lung cancer].

Objective: To investigate whether dendritic cells pulsed with whole tumor lysates (WTL) could in vitro elicit antitumor T cell responses in patients with non-small-cell lung cancer (NSCLC).

Methods: Monocyte-derived immature DCs (imDCs) generated in the presence of human recombinant granulocyte-macrophage colony stimulating factor and interleukin-4 from peripheral blood mononuclear cell of NSCLC patients, and then were induced to mature by pulsing autologous WTL (DCs/WTL) or by the addition of TNF-alpha(TNF/DCs). FACS and MLR assay were used to monitor their phenotypic changes and capacity to stimulate allogeneic and autologous T cell proliferation.

[Correlation between expression of vascular endothelial growth factor and prognosis of patients with esophageal squamous cell carcinoma].

Background & Objectives: Angiogenesis plays an essential role in tumor growth, invasion, and metastasis. Vascular endothelial growth factor(VEGF) is regarded the most important angiogenetic growth factor and it has been found in many kinds of tumors that its high expression can promote tumor progression and effect prognosis. However, there was few reports about the relationship between the VEGF expression and the progression and prognosis of the patients with esophageal carcinoma.