Dietary inflammatory potential and the risk of nonfatal cardiovascular diseases in the China Health and Nutrition Survey.

Background: To our knowledge, no evidence exists to link dietary inflammatory potential to cardiovascular disease (CVD) in China. Furthermore, the precise mechanisms underlying the link between a pro-inflammatory diet and CVD remain incompletely understood.

Objective: We aimed to investigate the relationship between dietary inflammatory potential and nonfatal CVD in the Chinese population and to explore the mediating role of insulin resistance.

Association of dietary calcium intake at dinner versus breakfast with cardiovascular disease in U.S. adults: the national health and nutrition examination survey, 2003-2018.

Background: Currently, it is still largely unknown whether the proportion of calcium intake at breakfast and dinner is associated with cardiovascular disease (CVD) in the general population.

Objectives: The aim of this study was to evaluate the association of dietary calcium intake at dinner versus breakfast with CVD in a nationally representative sample of US adults.

Methods: The study population consisted of 36,164 US adults (including 4,040 CVD cases) from the NHANES 2003 to 2018.

Comprehensive Analysis on Prognostic Signature Based on T Cell-Mediated Tumor Killing Related Genes in Gastric Cancer.

Although immunotherapy is a valuable treatment for gastric cancer (GC), identifying the patients who would benefit most from this approach presents a challenge. In this study, GC patients were divided into two subtypes by consensus clustering according to T cell-mediated tumor killing related genes (TTKRGs), and there were significant differences in tumor-infiltrating immune cells, signaling pathways, and gene expression of immunomodulators and inhibitory immune checkpoints between the two subtypes. Then, we developed an individualized signature based on TTKRGs, and its clinical and predictive value in GC patients for chemotherapeutic and immunotherapeutic responses was assessed.

Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice.

Prior studies indicated the involvement of neuroinflammation in the dopaminergic neurodegeneration in mice of paraquat (PQ)-induced Parkinson's disease (PD), but the underlying mechanisms remain to be elucidated. The present study explored whether microglia-mediated inflammation disrupted blood-brain barrier (BBB) and its related mechanism. C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks, following with or without minocycline (intraperitoneal injection, once every two days).

Association Between the Risk of Hyperuricemia and Changes in Branched-Chain Amino Acids Intake Over Twelve Years: A Latent Class Trajectory Analysis From the China Health and Nutrition Survey, 1997-2009.

Objective: This study aims to identify dietary branched-chain amino acids (BCAA) consumption trajectories in Chinese adults and to evaluate their association with the risk of hyperuricemia (HU).

Methods: Cohort data from the China Health and Nutrition Survey 1997-2009 were adopted in this research. A total of 6,810 participants aged ≥18 years were included in this study.

Risk and Prognosis of Second Primary Cancers among Ovarian Cancer Patients, Based on SEER Database.

The purposes of the present study were to elucidate the risk and prognostic effect of second primary cancers (SPCs) development, as well as the factors influencing the prognosis of OC patients with SPCs. A statistically significant increase in SPCs risk was observed among OC patients during 2004-2015. The independent factors were used to construct the SPCs-prediction nomogram and the OS-prediction nomogram.

Association between risk of type 2 diabetes and changes in energy intake at breakfast and dinner over 14 years: a latent class trajectory analysis from the China health and nutrition Survey, 1997-2011.

Objective: This study aimed to investigate the association between the trajectories of energy consumption at dinner versus breakfast and the risk of type 2 diabetes (T2D).

Design: Cohort study.

Setting: The study was conducted in China.

The association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus in a cohort study: The China Health and Nutrition Survey, 1997-2011.

Background: This study aims to investigate the association of energy and macronutrient intake at dinner vs breakfast with the incidence of type 2 diabetes mellitus (T2DM).

Methods: A total of 11 153 adults, including 811 with T2DM, completed a questionnaire about energy and macronutrient intake in the China Health and Nutrition Survey (1997-2011). The differences (Δ) in energy and macronutrient intake between dinner and breakfast (Δ = dinner - breakfast) were categorized into quintiles.

Construction of few-layered black phosphorus/graphite-like carbon nitride binary hybrid nanostructure for reducing the fire hazards of epoxy resin.

Black phosphorus (BP) and graphite-like carbon nitride (g-CN) were combined to prepare BP-CN hybrid nanostructure through a simple self-assembly method assisted by ultra-sonication, and as-obtained materials were further used as fire retardants introduced into epoxy resin to fabricate EP/BP-CNx nanocomposites. It was found that the introduction of 2 wt% BP-CNx into EP contributed to considerable decrements in peak heat release rate (up to 47.72%) and total heat release (utmost to 49.

Nacre-Inspired Black Phosphorus/Nanofibrillar Cellulose Composite Film with Enhanced Mechanical Properties and Superior Fire Resistance.

Natural nacre offers an optimized guiding principle for the assembly of lightweight and high-strength nanocomposites with excellent mechanical properties. Inspired by the "brick-and-mortar" layered structure of natural nacre, we present a cohort of bioinspired nanocomposites consisting of nanofibrillar cellulose (NFC) and few-layer hydroxyl functionalized black phosphorus (BP-OH) via a vacuum-assisted filtration self-assembly procedure. Owing to the well dispersed two-dimensional (2D) BP-OH in one-dimensional (1D) NFC and strong interfacial hydrogen bonding between them, these novel nacre-like BP-OH/NFC composite films show excellent mechanical performance with tensile strength up to 214.

Combination of black phosphorus nanosheets and MCNTs via phosphoruscarbon bonds for reducing the flammability of air stable epoxy resin nanocomposites.

As a rising star of two-dimensional material, black phosphorus (BP) has attracted tremendous attention in applications of photovoltaics, transistors and batteries due to its unique characteristics. Inspiring, we developed a simple strategy to fabricate BP-MCNTs as highly promising inorganic phosphorus-based flame retardant. After incorporation 2 wt% BP-MCNTs11(the mass ratio of BP:MCNTs=1:1) nanohybrid, the peak of heat release rate and total heat release of EP nanocomposites reduced by 55.

Nonreceptor tyrosine phosphatase 14 promotes proliferation and migration through regulating phosphorylation of YAP of Hippo signaling pathway in gastric cancer cells.

Background: The Hippo signaling pathway is associated with cell proliferation and organ size, and its transcriptional coactivator Yes-associated protein (YAP), emerges as a crucial oncoprotein in multiple cancers. It was increasingly recognized that nonreceptor tyrosine phosphatase 14 (PTPN14) was relevant to the cell membrane and cytoskeleton, and had a critical effect on cell adhesion, growth, and actin cytoskeleton organization. Furthermore, PTPN14 was also certified to operate the translocation and phosphorylation of YAP.

Aberrant methylation of and in peripheral blood leukocytes and their association with gastric cancer risk.

Aberrant DNA methylation, especially tumor suppressor gene hypermethylation, is a well-recognized biomarker of initial tumorogenesis stages. and are putative tumor suppressor genes and can be down-regulated by hypermethylation in various cancers tissues. However, in peripheral blood leukocytes, the association between these two genes methylation status, as well as the effects of gene-environment interactions, and gastric cancer (GC) risk remain unclear.

Association of peripheral blood leukocyte KIBRA methylation with gastric cancer risk: a case-control study.

KIBRA was reported to be involved in various types of cancer and can be detected in blood. The purpose of this study was to investigate the relationship between the status of KIBRA methylation in peripheral blood leukocytes and gastric cancer (GC) risk. A case-control study was carried out to evaluate the association of blood cell-derived KIBRA methylation with the risk of GC using methylation-sensitive high-resolution melting analysis.

Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer.

Aim: To investigate catalase (KatA) and alkyl hydroperoxide reductase (AhpC) antibodies of Helicobacter pylori as biomarkers for gastric cancer (GC).

Methods: This study included 232 cases and 264 controls. Recombinant KatA and AhpC proteins were constructed and the levels of antibodies were tested by indirect enzyme-linked immunosorbent assay (ELISA).

Serum Helicobacter pylori FliD antibody and the risk of gastric cancer.

FliD and CagA are important virulence factors of H. pylori. We aimed to evaluate the screening values of FliD and CagA for gastric cancer (GC).

Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH.

Background: Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the PPAR nuclear hormone receptor superfamily, which plays a crucial role in carcinogenesis. Wnt/β-Catenin signaling pathway has been well certified to contribute to the progression of gastric malignancies. β-Catenin mediates transcriptional regulation by forming a complex with LEF/TCF transcription factors, resulting in activation of downstream target genes such as TERT, ENAH.

PPARγ suppressed Wnt/β-catenin signaling pathway and its downstream effector SOX9 expression in gastric cancer cells.

Wnt signaling pathway activation plays a critical role in biological processes of tumor progression. SOX9 belongs to the sry-related high-mobility group box (SOX) family and is a key transcription factor in the development and differentiation of multiple cell lineages. The purpose of this study was to investigate whether suppression of Wnt signaling pathway by PPARγ gene affects target SOX9 gene expression.

rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population.

The aim of this study was to explore the association between polymorphisms in signal transducer and activator of transcription protein 3 (STAT3) and the risk of gastric cancer. In the present study, a case-control study was conducted in which rs2293152 and rs744166 polymorphisms in STAT3 were analyzed in 209 Chinese patients with gastric cancer and 294 cancer-free controls. The genotypes were determined by polymerase chain reaction restriction fragment length polymorphism method.

Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer.

Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer.

Polymorphisms of the TLR4 gene and risk of gastric cancer.

Objective: Toll-like receptor 4 (TLR4) is an important lipo-polysaccharide (LPS) receptor in gastric epithelial cell signaling transduction and plays critical roles in the development and progression of gastric cancer (GC). We investigated the effects of TLR4 gene polymorphisms and gene-environmental interactions on the risk of GC in Northeastern China.

Methods: We genotyped two single-nucleotide polymorphisms (SNPs) in TLR4 (rs10116253 and rs1927911) in 217 GC patients and 294 cancer-free controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Serum antibody against Helicobacter pylori FlaA and risk of gastric cancer.

Background: Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer (GC); however, only a minority of infected individuals develops GC. We aim to assess the association between serostatus of antibody against H.