Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin.

Background: Fever of unknown origin (FUO) without a respiratory component is a frequent clinical presentation in horses. Multiple pathogens, both tick-borne and enteric, can be involved as etiologic agents. An additional potential mechanism is intestinal barrier dysfunction.

A 3.2-3.6 GHz GaN Doherty Power Amplifier Module Based on a Compact Low-Loss Combiner.

In this paper, a 3.2-3.6 GHz two-stage Doherty power amplifier (PA) module is proposed for fifth-generation (5G) massive multiple-input multiple-output (MIMO) base stations.

Lactic acid/tartaric acid-maltitol antibacterial activity against spoilage bacteria and prevention of yellowing and wilting in spinach and oilseed rape.

The wilting and yellowing of leafy vegetables caused by spoilage bacteria resulted in serious resource wastage. This study investigated the efficacy of a combined lactic acid (LA) and tartaric acid (TA) treatment against four predominant spoilage bacteria (Erwinia persicina, Citrobacter freundii, Pseudomonas putida, and Pseudomonas punonensis) isolated from spinach and oilseed rape. Detailed analysis using Fourier-transform infrared spectroscopy, flow cytometry, scanning electron microscopy, and light microscopy revealed substantial cellular damage in the bacteria treated by LA and TA, including loss of intracellular material, and collapse of cellular morphology, as well as effective biofilm removal.

Recent advances and perspectives in synthetic applications of silylboronates as silyl radical precursors.

Silylboronates, as powerful and versatile reagents, have been widely used in synthetic chemistry over the past few decades, due to their ability to incorporate silicon and boron atoms into organic molecules. With the rapid development of radical chemistry, the use of silylboronates as silyl radical precursors has recently become a research focus in organic synthesis. Significant achievements have been made in the synthetic applications of silylboronates as silyl radical sources for various C-Si and C-X bond forming transformations.

Application of midnight-noon ebb-flow combined with five-element music therapy in continuous nursing of patients with chronic wounds.

Background: To investigate the effect of Midnight-noon Ebb-flow combined with five-element music therapy in the continuous nursing of patients with chronic wounds.

Methods: From March 2022 to November 2023, we recruited 50 eligible chronic wound patients and randomly divided them into two groups according to a random number table: the experimental group (n = 25) and the control group (n = 25). The control group was treated with conventional nursing measures.

CD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease.

Background: Metabolic alterations have been shown to instigate liver inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying mechanism is not fully elucidated. During MASLD progression, intrahepatic CD3TCRαβCD4CD8 double negative T regulatory cells (DNT) decrease cell survival and immunosuppressive function, leading to aggravated liver inflammation. In this study, we aim to reveal the underlying mechanisms that cause changes in DNT during MASLD progression.

Purinergic signaling by TCRαβ double-negative T regulatory cells ameliorates liver ischemia-reperfusion injury.

Hepatic ischemia-reperfusion injury (HIRI) is an important cause of liver injury following liver transplantation and major resections, and neutrophils are the key effector cells in HIRI. Double-negative T regulatory cells (DNT) are increasingly recognized as having critical regulatory functions in the immune system. Whether DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils, as in HIRI, remains largely unknown.

Mxene and GaIn Alloy Nanostructures Regulate Zn Surface Ion Deposition for High-Performance Zinc-Ion Battery.

Zinc is an ideal energy storage material because of its low toxicity, nonflammability, and good biocompatibility. However, the commercial application is seriously hindered due to problems such as dendrite growth, hydrogen evolution, and interface passivation caused by "dead zinc" in the process of cyclic deposition. Herein, a nanoscale deposition dispersion model is designed in order to achieve directional deposition and uniform distribution of zinc ions for the growth of interfacial dendrites.

[Research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells].

Objective: To review the research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells (MSCs).

Methods: An extensive review of the relevant literature on bone repair biomaterials, particularly those designed to recruit endogenous MSCs, was conducted, encompassing both domestic and international studies from recent years. The construction methods and optimization strategies for these biomaterials were summarized.

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis.

Background: The most common malignant bone tumour is osteosarcoma, which has an unsatisfactory prognosis and unsatisfactory treatment. Ferroptosis shows promise as an effective OS therapy. A substance extracted from the Lithospermum erythrorhizon, Shikonin (SHK), inhibits a number of tumours, including ovarian, gastric, and lung cancers.

Robotic-Assisted Versus Open Hemi-Hepatectomy: A Propensity Score Analysis.

Introduction: The robotic-assisted surgical system has been widely used in hepatectomy. However, the effectiveness and feasibility of robotic-assisted hemi-hepatectomy (RH) has not been well-documented.

Methods: Patients who underwent RH or open hemi-hepatectomy (OH) performed by a single surgeon at our hospital between January 2010 and August 2023 were included in this study.

Microstructure and Properties of Mg-Gd-Y-Zn-Mn High-Strength Alloy Welded by Friction Stir Welding.

Mg-Gd-Y-Zn-Mn (MVWZ842) is a kind of high rare earth magnesium alloy with high strength, high toughness and multi-scale strengthening mechanisms. After heat treatment, the maximum tensile strength of MVWZ842 alloy is more than 550 MPa, and the elongation is more than 5%. Because of its great mechanical properties, MVWZ842 has broad application potential in aerospace and rail transit.

Platelet-Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism.

Lipid metabolism reprogramming stands as a fundamental hallmark of cancer cells. Unraveling the core regulators of lipid biosynthesis holds the potential to find promising therapeutic targets in pancreatic ductal adenocarcinoma (PDAC). Here, it is demonstrated that platelet-derived growth factor C (PDGFC) orchestrated lipid metabolism, thereby facilitated the malignant progression of PDAC.

Enabling Quasi-Zero-Strain Behavior of Layered Oxide Cathodes via Multiple-cations Induced Order-to-Disorder Transition.

The chemically pre-intercalated lattice engineering is widely applied to elevate the electronic conductivity, expand the interlayer spacing, and improve the structural stability of layered oxide cathodes. However, the mainstream unitary metal ion pre-intercalation generally produces the cation/vacancy ordered superstructure, which astricts the further improvement of lattice respiration and charge-carrier ion storage and diffusion. Herein, a multiple metal ions pre-intercalation lattice engineering is proposed to break the cation/vacancy ordered superstructure.

N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance.

Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, we constructed gemcitabine-resistant PDAC cells and analyzed them with RNA-sequence.

Beneficial Effects of Concomitant Long-Acting Injectable Antipsychotics on Time to Rehospitalization in Patients With Treatment-Resistant Schizophrenia Receiving Clozapine: A Retrospective Cohort Study.

This study aimed to assess the association between long-acting injectable (LAI) antipsychotic prescription and the risk of psychiatric hospitalization in patients with treatment-resistant schizophrenia (TRS) receiving clozapine. In this retrospective cohort study at a single tertiary psychiatric center, we analyzed rehospitalization hazard ratios (HRs) in refractory schizophrenia patients, classified by and criteria. We examined various psychotropic regimens-clozapine with or without other oral antipsychotics (OAPs) or LAI antipsychotics.

Interlayer Entropy Engineering Inducing the Symmetry-Broken Layered Oxide Cathodes to Activate Reversible High-Voltage Redox Reaction.

The as-reported doping entropy engineering of electrode materials that are usually realized by the sharing of multiple metal elements with the metal element from the lattice body, potentially has three shortages of stringent synthesis conditions, large active element loss, and serious lattice distortion. Herein, an interlayer entropy engineering of layered oxide cathodes is proposed, where the multiple metal ions are simultaneously intercalated into the same interlayer sites, thus avoiding the three shortages. Concretely, a novel interlayer medium-entropy VO ((MnCoNiMgZn)VO∙0.

Rapid Endoscopic Diagnosis of Benign Ulcerative Colorectal Diseases With an Artificial Intelligence Contextual Framework.

Background & Aims: Benign ulcerative colorectal diseases (UCDs) such as ulcerative colitis, Crohn's disease, ischemic colitis, and intestinal tuberculosis share similar phenotypes with different etiologies and treatment strategies. To accurately diagnose closely related diseases like UCDs, we hypothesize that contextual learning is critical in enhancing the ability of the artificial intelligence models to differentiate the subtle differences in lesions amidst the vastly divergent spatial contexts.

Methods: White-light colonoscopy datasets of patients with confirmed UCDs and healthy controls were retrospectively collected.

Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδ T cells.

Background: Psoriasis is a chronic immune-mediated skin condition. Although biologic treatments are effective in controlling psoriasis, some patients do not respond or lose response to these therapies. Thus, new strategies for psoriasis treatment are still urgently needed.

Effect of continuous renal replacement therapy on the clinical efficacy and pharmacokinetics of polymyxin B in the treatment of severe pulmonary infection.

Objective: This study aimed to evaluate the pharmacokinetics of polymyxin B in patients with ventilator-associated pneumonia caused by multi-drug resistant bacteria, and to analyze the effect of continuous renal replacement therapy (CRRT) on pharmacokinetics of polymyxin B.

Methods: Thirty-five patients with ventilator-associated pneumonia caused by multi-drug resistant bacteria admitted to our hospital from June 2021 to January 2022 were selected as the subjects. The patients were divided into the standard group (n = 20) and the non-standard group (n = 15) based on the factors affecting the compliance of polymyxin B plasma concentration.

EPA and DHA Alleviated Chronic Dextran Sulfate Sodium Exposure-Induced Depressive-like Behaviors in Mice and Potential Mechanisms Involved.

Patients with ulcerative colitis (UC) have higher rates of depression. However, the mechanism of depression development remains unclear. The improvements of EPA and DHA on dextran sulfate sodium (DSS)-induced UC have been verified.

Research on the structure function recognition of PLOS.

Purpose: The present study explores and investigates the efficiency of deep learning models in identifying discourse structure and functional features and explores the potential application of natural language processing (NLP) techniques in text mining, information measurement, and scientific communication.

Method: The PLOS literature series has been utilized to obtain full-text data, and four deep learning models, including BERT, RoBERTa, SciBERT, and SsciBERT, have been employed for structure-function recognition.

Result: The experimental findings reveal that the SciBERT model performs outstandingly, surpassing the other models, with an F1 score.