Publications by authors named "Xiying Ren"
Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in HSCs.
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- * Researchers analyzed 70 allo-HSCT patients diagnosed with ICH and validated findings with an additional 41 patients from other medical centers to create the LAWS score, which predicts 30-day mortality based on four key factors: lactate dehydrogenase, albumin, white blood cell count, and disease status.
- * The LAWS score demonstrated strong predictive abilities in both cohorts and is the first tool of its kind for assessing early mortality risk in allo-H
Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to frequent anaemia and decreased adaptive immunity. How intrinsic changes to the hematopoietic stem cells (HSCs), an altered microenvironment and systemic factors contribute to this process is not fully understood. Here we use bone marrow stromal cells as sensors of age-associated changes to the bone marrow microenvironment, and observe up-regulation of IL-6 and TGFβ signalling-induced gene expression in aged bone marrow stroma.
View Article and Find Full Text PDFImmune-mediated neuropathies (IMNs) following hematopoietic stem cell transplantation have been described recently, which, excluding Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy, may present with atypical patterns. This retrospective, nested, case-control study reviewed data from 3858 patients who received haploidentical hematopoietic stem cell transplantation (haplo-HSCT) during the past 10 years at a single center, and 40 patients (1.04%) with IMN following haplo-HSCT were identified.
View Article and Find Full Text PDFValue of top-hat procedure in management of squamous intraepithelial lesion.
J Obstet Gynaecol Res
January 2019
Aim: To investigate the features of skip lesions and evaluate value of top-hat procedure in management of squamous intraepithelial lesion.
Methods: We reviewed the records of patients who underwent loop electrosurgical excision procedure (LEEP) in Peking University First Hospital between 2011 and 2016. Patients were confirmed to have CIN1-3.