SMG5, a component of nonsense-mediated mRNA decay, is essential for the mouse spermatogonial differentiation and maintenance.

Mammalian spermatogenesis is a tightly controlled cellular process including spermatogonial development and differentiation, meiosis of spermatocyte, and the morphological specification of haploid spermatozoa, during which the post-transcriptional gene regulations are vital but poorly understood. Nonsense-mediated mRNA decay (NMD), a highly conserved post-transcriptional regulatory mechanism of gene expression in eukaryotes, recently emerges as a licensing mechanism in cell fate transition, including stem cell differentiation and organogenesis. The function of NMD in spermatogonial development remains elusive.

A Latency-Optimized Network-on-Chip with Rapid Bypass Channels.

Network-on-Chips with simple topologies are widely used due to their scalability and high bandwidth. The transmission latency increases greatly with the number of on-chip nodes. A NoC, called single-cycle multi-hop asynchronous repeated traversal (SMART), is proposed to solve the problem by bypassing intermediate routers.