Publications by authors named "Xiyan Xia"
Background: Cervical cancer is one of the most common malignancies in women worldwide. As a RING type ubiquitin ligase, SIAH2 has been reported to promote the progression of a variety of tumors by interacting with and targeting multiple chaperones and substrates. The aim of this study was to further identify the role and the related molecular mechanisms involved of SIAH2 in cervical carcinogenesis.
View Article and Find Full Text PDFHPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic.
Hum Vaccin Immunother
December 2023
Article Synopsis
- The study examined the prevalence and distribution of human papillomavirus (HPV) genotypes among females in Shandong province, eastern China, in the context of the ongoing pandemic.
- The overall HPV infection rate was found to be 16.4%, with high-risk genotypes leading, particularly HPV16, HPV52, and HPV53.
- Results indicated that younger (≤25) and older (>55) age groups showed higher rates of multi-genotype infections, highlighting the need for targeted HPV screening and vaccination strategies.
Liquid biopsy has been receiving attention as an emerging detection technology in the clinical application of non-small-cell lung cancer (NSCLC). We quantified serum circulating free DNA (cfDNA) of syncytin-1 in 126 patients and 106 controls, analyzed the correlation of level with pathological parameters and explored diagnostic utility. The cfDNA of syncytin-1 levels in NSCLC patients were higher than healthy controls (p < 0.
View Article and Find Full Text PDFArticle Synopsis
- - Syncytin-1, a protein linked to cell fusion and immune functions, shows higher expression in non-small cell lung cancer (NSCLC) tissues compared to adjacent healthy tissues, with lower levels in patients who survive longer.
- - The study utilized Kaplan-Meier survival curves and Cox regression analysis to assess survival rates and risk factors, revealing that clinical stage and syncytin-1 positive cell percentage are major risk factors for NSCLC.
- - These results indicate that syncytin-1 has the potential to serve as a biomarker for diagnosing and predicting outcomes in NSCLC, warranting further research into its roles and regulatory mechanisms.
Syncytin 1 is considered as an oncogene in various malignant tumors, but its effect on non-small cell lung cancer (NSCLC) has not been reported. We investigated the specific role of Syncytin 1 on NSCLC through the transfection of Syncytin 1 knockdown or overexpression plamids in A549 cells. Our results proved that knockdown of Syncytin 1 inhibited the proliferation, and blocked the cell cycle on G1 phase by inhibiting the expression of Nusap1, Cyclin D1, CDK6, and CDK4.
View Article and Find Full Text PDFThe current study analyzed the correlation between the use of antibiotics and development of a resistant bacterial infection in 454 patients in intensive care units (ICUs), and this study also examined factors related to development of an infection in order to facilitate more rational use of antibiotics and to reduce the incidence of resistant bacterial infections. Potential subjects were patients who were admitted to the ICU in 2016, and 454 such patients were selected using cluster sampling. Patient information was documented using an original questionnaire, Patients in the ICU with a Resistant Bacterial Infection.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the expression of Tim-3, a protein, in T-cells of women with unexplained recurrent spontaneous abortion (URSA) compared to healthy controls, finding that Tim-3 mRNA levels were significantly higher in URSA patients.
- - Immunohistochemical analysis showed increased Tim-3 protein levels in the placental tissue of URSA patients, indicating a potential link between elevated Tim-3 expression and impaired maternal-fetal immune tolerance.
- - The findings suggest that Tim-3 could be involved in the mechanisms behind URSA and may serve as a potential biomarker for assessing immune responses in affected women.
Article Synopsis
- * It involved 184 patients split into two groups: one receiving standard nursing care and the other receiving the new intervention, focusing on individual needs and disease severity.
- * Results showed significant improvements in bowel function, quality of life, and patient satisfaction for those receiving the quantitative assessment-based intervention compared to the control group.
Objective: To observe the influence of RNA interference targeting against survivin gene on the biological behaviors of human adenoid cystic cancer (ACC) cells and propose the action mechanism.
Method: Specific siRNA (small interfering RNA) was constructed and transfected into ACC-2 cells using liposomes. The expressions of survivin and Caspase-3 in the transfected ACC-2 cells were detected by Western Blot and RT-PCR.
Article Synopsis
- * Results revealed that 94.3% of IgAN patients showed positive Tim-3 staining, while only 15.4% of the control group did, indicating a strong association between Tim-3 expression and the presence of IgAN.
- * Additionally, a significant correlation was found between Tim-3 expression and various serological markers reflecting disease activity in IgAN patients, highlighting Tim-3's potential role in evaluating the condition.
Syncytin-1 is a protein coded by a human endogenous retrovirus (HERV) gene of the HERV-W family (HERVWE1). Syncytin- 1 mediates formation of syncytiotrophoblasts through fusion of cytotrophoblasts, a hallmark of terminal differentiation of placental trophoblast linage. Syncytin-1 also possesses nonfusogenic functions and regulates cell cycle progression.
View Article and Find Full Text PDFT-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3) is a membrane protein expressed in various kinds of immune cells and plays a pivotal role in immune regulation. Recently, TIM-3 was reported to be expressed aberrantly in melanoma cells, contributing to the low adhesion ability of tumor cells and promoting the survival of melanoma cells. We investigated TIM-3 expression in non-small cell lung cancers (NSCLCs), and further analyzed whether the aberrant expression of TIM-3 is related to the prognosis for patients with lung cancer.
View Article and Find Full Text PDFA high number of CD8+ T cells infiltrated in NSCLC tissues is associated with a favorable prognosis.
Appl Immunohistochem Mol Morphol
January 2010
Article Synopsis
- - The study analyzed the number of intratumoral tumor-infiltrating lymphocytes (TILs), specifically CD4(+), CD8(+), and CD25(+) T cells, in patients with nonsmall cell lung cancer (NSCLC) and how it relates to their survival.
- - Tumor specimens from 30 patients were collected during surgery, and patients were categorized based on whether they survived 5 years or not, with findings showing that lower counts of CD8(+) T cells were linked to significantly shorter survival times (P < 0.05).
- - The research concluded that a higher presence of CD8(+) T cells in tumors is a strong predictor of better clinical outcomes, while the counts