Publications by authors named "Xiyan Liu"

Background: Study the treatment of poststroke depression and insomnia using varied repetitive transcranial magnetic stimulation (rTMS) frequencies alongside paroxetine. Aim to enhance rTMS effectiveness for depression, insomnia, neurological impairment, and daily living skills.

Methods: Ninety poststroke depression (PSD) patients were randomly divided into a low-frequency group (low-frequency rTMS + enteric-coated paroxetine), a high-frequency group (high-frequency rTMS + enteric-coated paroxetine), and a control group (sham stimulation + enteric-coated paroxetine).

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  • Sarcopenia is a muscle disorder in which there is a significant loss of muscle mass and function, with few effective drug treatments available.
  • The study discovered a strong link between low selenium levels in the blood and muscle function in elderly individuals suffering from sarcopenia, leading researchers to suggest that selenium supplementation could help manage this condition.
  • Researchers developed nanoparticles that release selenium and leucine, which improved muscle function by regulating certain cell signaling pathways and showed promise as a safe and effective treatment for sarcopenia.
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Introduction: Many articles suggest that clozapine was strongly associated with a higher incidence of new-onset diabetes mellitus, and the issue has remained unsettled. Many articles have compared clozapine with FGAs, but few have compared clozapine with SGAs. We aimed to compare the risk of new-onset diabetes mellitus in adults with schizophrenia treated with clozapine and other SGAs.

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Different from the previous neutral reaction solvent system, this work explores the synthesis of Al-oxo rings in ionic environments. Deep eutectic solvents (DESs) formed by quaternary ammonium salts hydrogen bond acceptor (HBA) and phenols hydrogen bond donor (HBD) further reduce the melting point of the reaction system and provide an ionic environment. Further, the quaternary ammonium salt was chosen as the HBA because it contains a halogen anion that matches the size of the central cavity of the molecular ring.

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Exploration effective route to convert plastic waste into valuable carbon dots with bifunction of metal fluorescence monitoring and corrosion protection in seawater is promising. Herein, using "white-pollution" polypropylene surgical masks as a single precursor, dual-emitting carbon dots (CDs) with excellent ratiometric fluorescent sensitivity and corrosion inhibitor efficiency were fabricated with high yield (∼100 %) by a one-pot in situ acid oxidation hydrothermal strategy without post-treatment and organic solvents. Chemical, structural, morphological, optical properties and the Cr (VI) detection and Cu inhibition mechanism of the synthesized CDs had been systematically studied.

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  • - Adipose tissue is a key player in obesity, serving as a major source of circulating microRNAs (miRNAs) which may help predict obesity-related health issues.
  • - A systematic review collected data from various databases and identified thirty miRNAs linked to obesity, along with seventy-nine validated targets relating to multiple obesity-related diseases.
  • - The study explored the mechanisms of miRNA production and their connections to various biological pathways, aiding in understanding the epigenetic factors involved in obesity-related health complications.
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  • Myoprotein degradation increases in obese individuals, leading to a loss of muscle mass, with Atg7 being a key player in regulating protein stability through various pathways.
  • The study utilized a mouse model of diet-induced obesity to investigate the effects of reducing Atg7 expression on muscle degradation and performance, involving multiple experimental techniques like immunofluorescence and western blotting.
  • Results showed that obesity resulted in a notable decrease in muscle area and performance, highlighting the complex role of Atg7 in muscle mass decline due to obesity.
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Background And Objective: Endothelial cell activation, characterized by increased levels of vascular cell adhesion molecule 1 (VCAM-1), plays a crucial role in the development of atherosclerosis (AS). Therefore, inhibition of VCAM-1-mediated inflammatory response is of great significance in the prevention and treatment of AS. The tripartite motif (TRIM) protein-TRIM65 is involved in the regulation of cancer development, antivirals and inflammation.

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Background: Immunoglobulin A nephropathy (IgAN) is a main cause of end stage renal disease (ESRD). Many IgAN patients with ESRD accept kidney allograft for renal replacement. However, disease recurrence occurs after transplantation.

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In order to enhance the take-off lift of a butterfly-like flapping wing vehicle (FWV), we implemented an integrated experimental platform and applied a reinforcement learning algorithm. The vehicle, which has a wingspan of 81 cm and is mounted on a stand with a force sensor, is driven by two servos that are powered and controlled wirelessly. To achieve the goal of enhancing take-off lift, we used a model-free, on-policy actor-critic proximal policy optimization algorithm.

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Pathological cardiac hypertrophy is a major cause of heart failure, and there is no effective approach for its prevention or treatment. The Trim family is a recently identified family of E3 ubiquitin ligases that regulate cardiac hypertrophy. Trim65, which is a member of the Trim family, previous studies have not determined whether Trim65 affects cardiac hypertrophy.

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Sirt1 is an NAD -dependent deacetylase that protects against premature aging and cell senescence. Aging accompanied by oxidative stress leads to a decrease in Sirt1 levels and activity, but the regulatory mechanism that connects these events remains unclear. Here, we reported that Nur77, which shares similar biological pathways with Sirt1, was also decreased with age in multiple organs.

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Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD.

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Mitochondria are important organelles that provide cellular energy and play a vital role in cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly caused by an imbalance in osteoblast and osteoclast activity. Under physiological conditions, mitochondria regulate the balance between osteogenesis and osteoclast activity and maintain bone homeostasis.

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An abdominal aortic aneurysm (AAA) is a progressive dilatation of the vascular wall occurring below the aortic fissure, preferably occurring below the renal artery. The molecular mechanism of AAA has not yet been elucidated. In the past few decades, research on abdominal aortic aneurysm has been mainly focused on the vessel wall, and it is generally accepted that inflammation and middle layer fracture of the vessel wall is the core steps in the development of AAA.

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Lipid metabolism is a complex biochemical process that regulates normal cell activity and death. Ferroptosis is a novel mode of programmed cell death different from apoptosis, pyroptosis, and autophagy. Abnormal lipid metabolism may lead to lipid peroxidation and cell rupture death, which are regulated by lipoxygenase (LOX), long-chain acyl-coA synthases, and antioxidant enzymes.

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Tungsten disulphide has attracted great research interest due to its layered structure as well as physical and chemical properties. A less common type of tungsten sulphide, WS, has also been studied as an electrochemical catalyst, but its crystal structure remains unclear because it has only been prepared in the amorphous form. In this work, crystalline WS is synthesized with a desert-rose-like morphology through the sulphurization of WO·0.

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Hippo, an evolutionarily conserved kinase cascade reaction in organisms, can respond to a set of signals, such as mechanical signals and cell metabolism, to maintain cell growth, differentiation, tissue/organ development, and homeostasis. In the past ten years, Hippo has controlled the development of tissues and organs by regulating the process of cell proliferation, especially in the field of cardiac regeneration after myocardial infarction. This suggests that Hippo signaling is closely linked to cardiovascular disease.

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In recent decades, a dramatic rise has been observed in the prevalence of obesity in childhood and adolescence, along with an increase in fetal microsomia rates. The increased risk of obesity during this key period in development negatively affects the health of the individual later in life. Immune cells residing and recruited to white adipose tissue have been highlighted as important factors contributing to the pathogenesis of childhood obesity.

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Inflammation is a double-edged sword. The moderate inflammatory response is a fundamental defense mechanism produced by the body's resistance to dangerous stimuli and a repair process of the body itself. Increasing studies have confirmed that the overactivation of the inflammasome is involved in the occurrence and development of inflammatory diseases.

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Objectives: To evaluate the impact of autoantibodies against the M2-muscarinic receptor (anti-M2-R) on the clinical outcomes of patients receiving the standard treatment for peripartum cardiomyopathy (PPCM).

Methods: A total of 107 PPCM patients who received standard heart failure (HF) treatment between January 1998 and June 2020 were enrolled in this study. According to anti-M2-R reactivity, they were classified into negative (n = 59) and positive (n = 48) groups, denoted as the anti-M2-R (-) and anti-M2-R (+) groups.

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Molybdenum borides have been of interest due to their potential applications as electrocatalysts for the hydrogen evolution reaction (HER). As one of the common molybdenum borides, β-MoB is deemed to exhibit low electrocatalytic activity due to the presence of puckered B layers, and improvement of its behavior is hindered by the lack of convenient synthetic methods. Herein, we report the synthesis of crystalline β-MoB for the first time via the simple reaction of MoCl and B at 850 °C in LiCl-KCl.

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Krypton (Kr) and xenon (Xe) are nowadays widely applied in technical and industrial fields. Separating and collecting highly pure Xe from nuclear facilities are necessary and urgent. However, the technology is limited due to the inert nature of Xe and other interferential factors.

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