Publications by authors named "Xiya Ren"
Copper is a vital cofactor in various enzymes, plays a pivotal role in maintaining cell homeostasis. When copper metabolism is disordered and mitochondrial dysfunction is impaired, programmed cell death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy and necroptosis can be induced. In this review, we focus on the metabolic mechanisms of copper.
View Article and Find Full Text PDFLupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis. Macrophages play an important role in its pathogenesis. Different macrophage subtypes have different effects on lupus-affected kidneys.
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- Acute respiratory distress syndrome (ARDS) is primarily caused by sepsis and involves inflammation resolution through mediators like resolvin D1 (RvD1), though the exact role of resident alveolar macrophages (RAMs) in this process needs clarification.
- Researchers created a mouse model of ARDS and administered RvD1 during peak inflammation to study its impact on RAMs, assessing their proliferation and phagocytic ability, while also analyzing plasma samples from ICU patients for RvD1 and S100A8/A9 levels.
- The findings demonstrated that RvD1 enhances RAM proliferation and phagocytosis through the ALX/MAPK14/S100A8/A9 pathway and indicates lower RvD1 but higher S
Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating clinical conditions characterized by pulmonary epithelial damage and protein-rich fluid accumulation in the alveolar spaces. Statins are a class of HMG-CoA reductase inhibitors, which exert cholesterol-lowering and anti-inflammatory effects.
Methods: Rosuvastatin (1 mg/kg) was injected intravenously in rats 12 h before lipopolysaccharide (LPS, 10 mg/kg) administration.