A Combination of EGFR Inhibitors and AE-PDT Could Synergistically Suppress Breast Cancer Progression.

Background: Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancerrelated deaths in women. Activation of EGFR by EC-secreted EGFR ligands promotes breast cancer progression. Current treatments provide limited benefits in triple-negative breast cancer (TNBC).

Dynamic Crushing Behavior of Ethylene Vinyl Acetate Copolymer Foam Based on Energy Method.

This paper aimed to experimentally clarify the dynamic crushing mechanism and performance of ethylene vinyl acetate copolymer (EVA) and analyze the influence of density and thickness on its mechanical behavior and energy absorption properties under dynamic impact loadings. Hence, a series of dynamic compression tests were carried out on EVA foams with different densities and thicknesses. When the impact energy is 66.

Recent advances in differential expression analysis for single-cell RNA-seq and spatially resolved transcriptomic studies.

Differential expression (DE) analysis is a necessary step in the analysis of single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) data. Unlike traditional bulk RNA-seq, DE analysis for scRNA-seq or SRT data has unique characteristics that may contribute to the difficulty of detecting DE genes. However, the plethora of DE tools that work with various assumptions makes it difficult to choose an appropriate one.

The ALK1‑Smad1/5‑ID1 pathway participates in tumour angiogenesis induced by low‑dose photodynamic therapy.

Photodynamic therapy (PDT) is an effective and low‑invasive tumour therapy. However, it can induce tumour angiogenesis, which is a main factor leading to tumour recurrence and metastasis. Activin receptor‑like kinase‑1 (ALK1) is a key factor regulating angiogenesis.

The lag effect of exposure to PM on esophageal cancer in urban-rural areas across China.

Exposure to PM pollution is a significant health concern and increases risks for cancers in China. However, the studies regarding the effect of PM and esophageal cancer incidence (ECI) among urban-rural areas are limited. In this study, we examined the sex- and area-specific association between exposure to PM and ECI, as well as explored the corresponding lag effects on ECI using a geographical weighted Poisson regression.

The associations of air pollution and socioeconomic factors with esophageal cancer in China based on a spatiotemporal analysis.

Rapid urbanization and industrialization in China have incurred serious air pollution and consequent health concerns. In this study, we examined the modifying effects of urbanization and socioeconomic factors on the association between PM and incidence of esophageal cancer (EC) in 2000-2015 using spatiotemporal techniques and a quasi-Poisson generalized linear model. The results showed a downward trend of EC and high-risk areas aggregated in North China and Huai River Basin.

Spatial-temporal characteristics of nitrogen degradation in typical Rivers of Taihu Lake Basin, China.

In this study, we focus on the measurement of different nitrogen (N) forms and investigate the spatial-temporal variability of degradation coefficient in river channels. We aim to provide a new approach of deriving in-situ degradation coefficients of different N forms, and highlight factors that determine the spatial-temporal variability of degradation coefficients. Our results are based on a two-year field survey in 34 channels around the Taihu Lake Basin, eastern China.

[Distribution and Pollution Assessment of Nutrients in the Surface Sediments of a Macrophyte-Dominated Zone in Lake Taihu].

To clarify the spatial distribution and pollution status of nutrients in the surface sediments from a macrophyte-dominated zone in Lake Taihu, total nitrogen (TN), total phosphorus (TP), alkali nitrogen (AN), available phosphorus (AP), and organic matter (OM) were measured at 60 sampling sites in Xukou Bay. A pollution evaluation and source apportionment analysis of these nutrients was also carried out. The average contents of TN, TP, AN, AP, and OM in the surface sediments of Xukou Bay were 1027.

[Spatial Distribution and Pollution Assessment of Heavy Metals in River Sediments from Lake Taihu Basin].

To clarify the pollution characteristics of heavy metals in the surface sediments of rivers in economically developed areas, analysis of the contents of eight heavy metals, assessment of ecological risks, and identification of the source of heavy metals in surface sediments from typical rivers of Lake Taihu Basin were carried out in this study. The results showed that the average contents of Zn, Cr, Ni, Cu, Pb, As, Cd, and Hg in the surface sediments of Lake Taihu Basin were 163.62, 102.

Spatio-Temporal Differences in Nitrogen Reduction Rates under Biotic and Abiotic Processes in River Water of the Taihu Basin, China.

Understanding spatio-temporal differences in nitrogen (N) transformation, transport and reduction rates in water bodies is critical to achieve effective mitigation of river eutrophication. We performed culture experiments in six rivers in the Taihu Basin using a custom made in-situ experimental apparatus. We investigated spatio-temporal differences in reduce processes and rates of different N forms and assessed the contribution of biological processes to dissolved inorganic N (DIN) reduce.