Publications by authors named "Xixing Fang"
Article Synopsis
- The immune system is essential for regulating body functions and consists of various immune cells, organs, and signaling factors, but it experiences decline as a person ages, known as 'immune aging.'
- Aging leads to negative changes in immune cell function, such as poorer neutrophil movement and reduced macrophage activity, resulting in inadequate responses to infections, vaccinations, and an increased risk of autoimmune disorders.
- Immune aging affects not just individual cells but also organs like bone marrow and the thymus, contributing to chronic inflammation and higher chances of developing age-related diseases like Alzheimer's and osteoporosis, prompting the need for research into potential anti-aging strategies targeting immune function.
Polygalasaponin F (PGSF), an oleanane triterpenoid saponin extracted from Polygala japonica, has been demonstrated with neuroprotective effect. However, the therapeutic effects and mechanisms of PGSF on focal ischemia remain unknown; METHODS: In this study, male Sprague Dawley (SD) rats aged 6-8 weeks were initially selected to establish a rat model of middle cerebral artery occlusion (MCAO) to evaluate the therapeutic effect of PGSF intervention and to investigate the impact of PGSF on the thioredoxin-interacting protein/NOD-, LRR-, and pyrin domain-containing protein 3 (TXNIP/NLRP3) inflammatory pathway. Secondly, brain neuron cells were isolated, and the cells received oxygen-glucose deprivation/reoxygenation (OGD/R) culture to establish the cell injury model in vitro.
View Article and Find Full Text PDFJian-Gan-Xiao-Zhi decoction (JGXZ) has demonstrated beneficial effects on nonalcoholic fatty liver disease (NAFLD). However, the mechanisms by which JGXZ improve NAFLD are still unclear. In this study, we first used a high-fat diet (HFD) to establish a NAFLD rat model to clarify the therapeutic effect of JGXZ on NAFLD.
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