Prediction of PD-L1 tumor positive score in lung squamous cell carcinoma with H&E staining images and deep learning.

Background: Detecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. However, this method has problems such as high staining costs, tumor heterogeneity, and subjective differences among pathologists. Therefore, the application of deep learning models to segment and quantitatively predict PD-L1 expression in digital sections of Hematoxylin and eosin (H&E) stained lung squamous cell carcinoma is of great significance.

MCRANet: MTSL-based connectivity region attention network for PD-L1 status segmentation in H&E stained images.

The quantitative analysis of Programmed death-ligand 1 (PD-L1) via Immunohistochemical (IHC) plays a crucial role in guiding immunotherapy. However, IHC faces challenges, including high costs, time consumption and result variability. Conversely, Hematoxylin-Eosin (H&E) staining offers cost-effectiveness, speed, and stable results.

The long non-coding RNA OLC8 enhances gastric cancer by interaction with IL-11.

Background: The gastric cancer (GC) represents a common malignancy especially in China. Long non-coding RNAs (lncRNAs) are critically involved in various types of cancer. However, the underlying mechanisms of OLC8 in gastric cancer are still largely unknown.

Soy protein isolate as a nanocarrier for enhanced water dispersibility, stability and bioaccessibility of β-carotene.

Background: The incorporation of β-carotene, one of the most common pigments or bioactives, into food formulations has attracted increasing interest from the food industry, due to its good nutrition and potential health effects. However, it is poorly soluble and unstable in water, which greatly limits its applications in foods. This work presented an effective approach to improve the water dispersibility, stability and even bioaccessibility of β-carotene, using soy protein isolate (SPI) to perform as effective nanocarriers for this molecule.