Efficacy of puerarin in rats with focal cerebral ischemia through modulation of the SIRT1/HIF-1α/VEGF signaling pathway and its effect on synaptic plasticity.

This study aimed to evaluate the efficacy of puerarin and its effect on synaptic plasticity in rats with focal cerebral ischemia (FCI) by modulating the silent mating type information regulation 2 homolog (SIRT1)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. Fifty specific pathogen-free-grade healthy male rats were randomly divided into sham operation group (SOG), model group, low-dose group, medium-dose group, and high-dose group, with 10 rats in each group. The SOG group received sham operation and saline treatment, while the other four groups received the same amount of saline, 25 mg/kg, 50 mg/kg, and 100 mg/kg of puerarin injection, respectively.

An effect analysis of vestibular rehabilitation training in vertigo treatment.

Objective: This study aimed to explore the clinical safety and effectiveness of vestibular rehabilitation training in the treatment of vertigo.

Methods: Patients with vertigo were randomly divided into an experimental group (51 cases) or a control group (51 cases) and were treated for 4 weeks. The Berg balance scale scores (BBS), the vestibular symptom index (VSI) scores, the balance experiment scores, the UCIA vertigo scores, and the vertigo symptom changes before and after the treatment were recorded, and the treatment success was investigated.