Publications by authors named "Xiwei Gu"
J Biol Chem
November 2024
Article Synopsis
- Cardiotoxicity during drug treatment is a significant concern, especially regarding the role of cardiac hERG channels in the heart's action potential repolarization.
- Chelerythrine shows promise as an anti-cancer agent but its safety profile, particularly concerning cardiac effects, is not well understood.
- This study finds that Chelerythrine can prolong the QT interval and action potential duration, potentially increasing the risk of cardiac toxicity through enhanced degradation of hERG channels via ubiquitination and lysosomal pathways under hypoxic conditions.
