Epigallocatechin-3-gallate attenuates fluoride induced apoptosis via PI3K/FoxO1 pathway in ameloblast-like cells.

Fluoride is a double-edged sword. It was widely used for early caries prevention while excessive intake caused a toxicology effect, affected enamel development, and resulted in dental fluorosis. The study aimed to evaluate the protective effect and mechanism of Epigallocatechin-3-gallate (EGCG) on the apoptosis induced by fluoride in ameloblast-like cells.

Effect of Dimethyloxalylglycine on Stem Cells Osteogenic Differentiation and Bone Tissue Regeneration-A Systematic Review.

Dimethyloxalylglycine (DMOG) has been found to stimulate osteogenesis and angiogenesis of stem cells, promoting neo-angiogenesis in bone tissue regeneration. In this review, we conducted a comprehensive search of the literature to investigate the effects of DMOG on osteogenesis and bone regeneration. We screened the studies based on specific inclusion criteria and extracted relevant information from both in vitro and in vivo experiments.

Novel pit and fissure sealant containing nano-CaF and dimethylaminohexadecyl methacrylate with double benefits of fluoride release and antibacterial function.

Objective: Pit and fissure sealants with antibacterial and remineralization properties have broad application prospects in caries prevention. The objectives of this study were to: (1) develop a novel pit and fissure sealant containing CaF nanoparticles (nCaF) and dimethylaminohexadecyl methacrylate (DMAHDM); and (2) investigate the effects of nCaF and DMAHDM on biofilm response and fluoride (F) ion release for the first time.

Methods: Helioseal F was used as a control.

Fracture resistance and stress distribution of repairing endodontically treated maxillary first premolars with severe non-carious cervical lesions.

This study was to compare the influence of glass fiber post placement and crown restoration on endodontically treated maxillary first premolars with severe NCCLs using three-dimensional finite element analysis and fracture resistance testing. G1, intact teeth. G2, teeth with artificial defect.

NaF Reduces KLK4 Gene Expression by Decreasing Foxo1 in LS8 Cells.

Decreased expression and increased phosphorylation of Forkhead box o1 (Foxo1) in ameloblasts were observed both in vivo and in vitro when treated by fluoride. The present study aims to investigate the possible relationship between Foxo1 and enamel matrix proteinases, matrix metalloproteinase 20 (MMP20), and kallikrein 4 (KLK4), in NaF-treated ameloblasts. Ameloblast-like cells (LS8 cells) were exposed to NaF at selected concentration (0/2 mM) for 24 h.

Fracture resistance of palatal cusps defective premolars restored with polyethylene fiber and composite resin.

The aim of the study was to compare the fracture resistance of the palatal cusps of defective and endodontically treated premolars after restoration with various restorative techniques. Fifty premolars were assigned to five groups. The first group comprised intact teeth as control (G1), while the other experimental groups (G2, G3, G4 and G5) comprised endodontically-treated teeth, whose palatal cusps were cut and reduced the buccal cusps by 2 mm.