Publications by authors named "Xiuzheng Jiang"
Int Heart J
November 2024
Article Synopsis
- Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) show potential in treating cardiovascular diseases by modulating pyroptosis in cardiac microvascular endothelial cells (CMECs).
- Exosomes were extracted from hUCMSCs, and their effects were tested on hypoxia/reoxygenation-induced CMECs and in a rat model of ischemia/reperfusion injury, revealing that hUCMSC-Exos improved cell survival and reduced cell death.
- The study found that hUCMSC-Exos decreased levels of pyroptosis-related proteins and inflammatory factors by inactivating the NLRP3 inflammasome/Caspase-1 pathway, suggesting a protective mechanism against cardiac
